{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF05768","protein_label":"Glutaredoxin-like protein C5orf63","reviewed":true,"short_name":"Glrx-like","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/glrx-like-pf05768.yaml","source_record_id":"Pfam:PF05768","source_record_label":"Glutaredoxin-like domain (DUF836)","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"A6NC05","unknown_status":"EX_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF05768","protein_label":"Glutaredoxin-2","reviewed":true,"short_name":"Glrx-like","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/glrx-like-pf05768.yaml","source_record_id":"Pfam:PF05768","source_record_label":"Glutaredoxin-like domain (DUF836)","source_section":"canonical_examples","taxon_id":"NCBITaxon:10254","taxon_label":"Vaccinia virus (strain Western Reserve)","uniprot_accession":"P68460","unknown_status":"EX_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF05768","protein_label":"Glutaredoxin-2","reviewed":true,"short_name":"Glrx-like","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/glrx-like-pf05768.yaml","source_record_id":"Pfam:PF05768","source_record_label":"Glutaredoxin-like domain (DUF836)","source_section":"canonical_examples","taxon_id":"NCBITaxon:265874","taxon_label":"Ectromelia virus (strain Moscow)","uniprot_accession":"Q8V507","unknown_status":"EX_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF05768","protein_label":"","reviewed":null,"short_name":"Glrx-like","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/glrx-like-pf05768.yaml","source_record_id":"Pfam:PF05768","source_record_label":"Glutaredoxin-like domain (DUF836)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"EX_DUF"}],"family":{"alphafold_models":7176,"candidate_reasons":["name_matches_duf","description_says_unknown_function","pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":3,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":1},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"These proteins are related to the [pfam:PF00462] family. This entry includes several viral glutaredoxins and many related bacterial and eukaryotic proteins of unknown function. The best characterised member is G4L ([swissprot:P68460]) from Vaccinia virus (strain Western Reserve/WR) (VACV), which is necessary for virion morphogenesis and replication [[cite:PUB00020627]]. This is a cytoplasmic protein which functions as a shuttle in a redox pathway between membrane-associated E10R and L1R or F9L [[cite:PUB00020628]].","domain_architectures":53,"interpro_id":"IPR008554","known_evidence_count":null,"matches":10669,"name":"Glutaredoxin-like domain (DUF836)","partial_evidence_count":null,"pfam_id":"PF05768","proteins":10668,"proteomes":10193,"short_name":"Glrx-like","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05768","structures":6,"taxa":16954,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF05768.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":7176,"domain_architectures":53,"matches":10669,"proteins":10668,"proteomes":10193,"structures":6,"taxa":16954},"curation_status":"SEEDED","description":"These proteins are related to the [pfam:PF00462] family. This entry includes several viral glutaredoxins and many related bacterial and eukaryotic proteins of unknown function. The best characterised member is G4L ([swissprot:P68460]) from Vaccinia virus (strain Western Reserve/WR) (VACV), which is necessary for virion morphogenesis and replication [[cite:PUB00020627]]. This is a cytoplasmic protein which functions as a shuttle in a redox pathway between membrane-associated E10R and L1R or F9L [[cite:PUB00020628]].","id":"Pfam:PF05768","interpro_id":"InterPro:IPR008554","name":"Glutaredoxin-like domain (DUF836)","pfam_id":"PF05768","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"Glrx-like","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05768"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF05768.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"73c3e80b8d276660af37fdaf19d150890f321a4d222fe7762d737d0f05450478"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/glrx-like-pf05768.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF05768","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/glrx-like-pf05768.yaml"}],"pfam_ids":["PF05768"],"protein_name":"Glutaredoxin-like protein C5orf63","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MLWFQGNSMQLARSSFGLFLRNCSASKTTLPVLTLFTKDPCPLCDEAKEVLKPYENRQPYKDQKLPGTRRRRSPSSPSHPHMASQSGKRYNLTLNQVLSFDYDMGLDAPKTISSDCGAFYCLRMFKSPDMTCCFYPKQ","sequence_length":138,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"e236afc44ae3cc1d4ac3d93fb1d050ecfc5c3a7629741ae715463d5e93015f7a","sequence_version":3,"source_url":"https://rest.uniprot.org/uniprotkb/A6NC05.json","taxon_id":"9606","uniprot_accession":"A6NC05","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Vaccinia virus (strain Western Reserve)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/glrx-like-pf05768.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF05768","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/glrx-like-pf05768.yaml"}],"pfam_ids":["PF05768"],"protein_name":"Glutaredoxin-2","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MKNVLIIFGKPYCSICENVSDAVEELKSEYDILHVDILSFFLKDGDSSMLGDVKRGTLIGNFAAHLSNYIVSIFKYNPQTKQMAFVDINKSLDFTKTDKSLVNLEILKSEIEKATYGVWPPVTE","sequence_length":124,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"28bcb258b4dacfeacc8450a9ba2e29bae115b700e70c895777ca2449fdb27af7","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P68460.json","taxon_id":"10254","uniprot_accession":"P68460","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Ectromelia virus (strain Moscow)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/glrx-like-pf05768.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF05768","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/glrx-like-pf05768.yaml"}],"pfam_ids":["PF05768"],"protein_name":"Glutaredoxin-2","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MKNVLIIFGKPYCSICENVSEAVEELKSEYDILHVDILSFFLKDGDSSMLGDVKRGTLIGNFAAHLSNYIVSIFKYNPQTKQMAFVDINKSLDFTKTDKSLVNLEILKSEIEKATYGVWPPVTE","sequence_length":124,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"fbe8b547e8cd1f7a547f7a2f2afbab510d4dea903f3be66f8a9669b515466780","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q8V507.json","taxon_id":"265874","uniprot_accession":"Q8V507","uniprot_release":"2026_03"}],"pfam_id":"PF05768","short_name":"Glrx-like","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
