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UNC93B1 controls intracellular trafficking and transport of a subset of Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades [[cite:PUB00097046]]. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons [[cite:PUB00097045]].","domain_architectures":156,"interpro_id":"IPR010291","known_evidence_count":null,"matches":11823,"name":"Ion channel regulatory protein UNC-93","partial_evidence_count":null,"pfam_id":"PF05978","proteins":11159,"proteomes":2949,"short_name":"UNC-93","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05978","structures":0,"taxa":8050,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF05978.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":9617,"domain_architectures":156,"matches":11823,"proteins":11159,"proteomes":2949,"structures":0,"taxa":8050},"curation_status":"SEEDED","description":"The proteins in this family are represented by UNC-93 from Caenorhabditis elegans and also includes protein unc-93 homologue A (UNC93A), protein unc-93 homologue B1 (UNC93B1), and UNC93-like protein MFSD11 (also called major facilitator superfamily domain- containing protein 11 or protein ET). UNC-93 colocalizes with SUP-10 and SUP-9 within muscle cells. UNC-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans [[cite:PUB00053696]]. UNC93B1 controls intracellular trafficking and transport of a subset of Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades [[cite:PUB00097046]]. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons [[cite:PUB00097045]].","id":"Pfam:PF05978","interpro_id":"InterPro:IPR010291","name":"Ion channel regulatory protein 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