{"cross_mech":[],"family":{"alphafold_models":4095,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family consists of bacterial proteins related to YacP. This family is uncharacterised functionally, but it has been suggested that these proteins are nucleases due to them containing a NYN domain. NYN (for N4BP1, YacP-like Nuclease) domains were discovered by Anantharaman and Aravind [[cite:PUB00056584]]. Based on gene neighborhoods it was suggested that the bacterial YacP proteins interact with the Ribonuclease III and TrmH methylase in a processome complex that catalyzes the maturation of rRNA and tRNA [[cite:PUB00056584]].","domain_architectures":33,"interpro_id":"IPR010298","known_evidence_count":null,"matches":6405,"name":"YacP-like NYN domain","partial_evidence_count":null,"pfam_id":"PF05991","proteins":6344,"proteomes":5929,"short_name":"NYN_YacP","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05991","structures":2,"taxa":9190,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF05991.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":4095,"domain_architectures":33,"matches":6405,"proteins":6344,"proteomes":5929,"structures":2,"taxa":9190},"curation_status":"SEEDED","description":"This family consists of bacterial proteins related to YacP. This family is uncharacterised functionally, but it has been suggested that these proteins are nucleases due to them containing a NYN domain. NYN (for N4BP1, YacP-like Nuclease) domains were discovered by Anantharaman and Aravind [[cite:PUB00056584]]. Based on gene neighborhoods it was suggested that the bacterial YacP proteins interact with the Ribonuclease III and TrmH methylase in a processome complex that catalyzes the maturation of rRNA and tRNA [[cite:PUB00056584]].","id":"Pfam:PF05991","interpro_id":"InterPro:IPR010298","name":"YacP-like NYN domain","pfam_id":"PF05991","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"NYN_YacP","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05991"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF05991.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"2c3a60c74a06a414735b11e7e1e6d6318da599540fe26ca3e31a7035c9d11ca4"}},"protein_examples":{"candidate_count":1,"discovery_scanned":true,"example_count":1,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Bacillus subtilis (strain 168)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/cdd/pin-domain-of-bacillus-subtilis-yacp-rae1-and-related-proteins-bacillu-cd10912.yaml","qualification_status":"NOT_ASSESSED","record_id":"CDD:cd10912","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/cdd/pin-domain-of-bacillus-subtilis-yacp-rae1-and-related-proteins-bacillu-cd10912.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/nyn-yacp-pf05991.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF05991","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/nyn-yacp-pf05991.yaml"}],"pfam_ids":["PF05991"],"protein_name":"Ribosome-associated endoribonuclease 1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MDILLVDGYNMIGAWPQLKDLKANSFEEARDVLIQKMAEYQSYTGNRVIVVFDAHLVKGLEKKQTNHRVEVIFTKENETADERIEKLAQALNNIATQIHVATSDYTEQWAIFGQGALRKSARELLREVETIERRIERRVRKITSEKPAGKIALSEEVLKTFEKWRRGDLD","sequence_length":170,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"62ecac24df917cc7edf597057ba8e29187c6bca3f8deeec88ad16e0c753360c9","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P37574.json","taxon_id":"224308","uniprot_accession":"P37574","uniprot_release":"2026_03"}],"pfam_id":"PF05991","short_name":"NYN_YacP","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}