{"cross_mech":[],"family":{"alphafold_models":2470,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This is the C-terminal domain found in NF-kappa-B-activating protein (Nkap) and a hypothetical open reading frame on chromosome 6, c6orf194. Functional studies in Nkap indicate that this domain is the HDAC3 binding domain and is required for transcriptional repression [[cite:PUB00075800]]. Nkap functions as a transcriptional repressor on Notch target genes, and is required for T cell development and acquisition of functional competency [[cite:PUB00075800],[cite:PUB00075801],[cite:PUB00075802]].","domain_architectures":67,"interpro_id":"IPR009269","known_evidence_count":null,"matches":2925,"name":"NF-kappa-B-activating protein C-terminal domain","partial_evidence_count":null,"pfam_id":"PF06047","proteins":2915,"proteomes":2230,"short_name":"Nkap_C","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06047","structures":4,"taxa":6580,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF06047.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":2470,"domain_architectures":67,"matches":2925,"proteins":2915,"proteomes":2230,"structures":4,"taxa":6580},"curation_status":"SEEDED","description":"This is the C-terminal domain found in NF-kappa-B-activating protein (Nkap) and a hypothetical open reading frame on chromosome 6, c6orf194. Functional studies in Nkap indicate that this domain is the HDAC3 binding domain and is required for transcriptional repression [[cite:PUB00075800]]. Nkap functions as a transcriptional repressor on Notch target genes, and is required for T cell development and acquisition of functional competency [[cite:PUB00075800],[cite:PUB00075801],[cite:PUB00075802]].","id":"Pfam:PF06047","interpro_id":"InterPro:IPR009269","name":"NF-kappa-B-activating protein C-terminal domain","pfam_id":"PF06047","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"Nkap_C","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06047"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF06047.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"fca15f47d979a4689a544ccbf037d5e6ffddd437eaacf80bd9439a626053c6f5"}},"protein_examples":{"candidate_count":5,"discovery_scanned":true,"example_count":5,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/nf-kappa-b-activating-protein-c-terminal-ipr009269.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR009269","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/nf-kappa-b-activating-protein-c-terminal-ipr009269.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/nkap-c-pf06047.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06047","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/nkap-c-pf06047.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/nkap-pf15692.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF15692","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/nkap-pf15692.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:Q5M9Q1","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF06047","PF15692"],"protein_name":"NKAP-like protein","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"8780a6aeca45f049b55ad1e529eb80cfc05a8e393eebc774229311890e35982c","sequence_version":3,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MPPVSRSSYSEDIVGSRRRRRSSSGSPPSPQSRCSSWDGCSRSHSRGREGLRPPWSELDVGALYPFSRSGSRGRLPRFRNYAFASSWSTSYSGYRYHRHCYAEERQSAEDYEKEESHRQRRLKERERIGELGAPEVWGPSPKFPQLDSDEHTPVEDEEEVTHQKSSSSDSNSEEHRKKKTSRSRNKKKRKNKSSKRKHRKYSDSDSNSESDTNSDSDDDKKRVKAKKKKKKKKHKTKKKKNKKTKKESSDSSCKDSEEDLSEATWMEQPNVADTMDLIGPEAPIIHTSQDEKPLKYGHALLPGEGAAMAEYVKAGKRIPRRGEIGLTSEEIGSFECSGYVMSGSRHRRMEAVRLRKENQIYSADEKRALASFNQEERRKRESKILASFREMVHKKTKEKDDK","sequence_length":402,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"8780a6aeca45f049b55ad1e529eb80cfc05a8e393eebc774229311890e35982c","sequence_version":3,"source_url":"https://rest.uniprot.org/uniprotkb/Q5M9Q1.json","taxon_id":"9606","uniprot_accession":"Q5M9Q1","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/nf-kappa-b-activating-protein-c-terminal-ipr009269.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR009269","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/nf-kappa-b-activating-protein-c-terminal-ipr009269.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/nkap-c-pf06047.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06047","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/nkap-c-pf06047.yaml"}],"pfam_ids":["PF06047"],"protein_name":"NKAP-like protein","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSPVSRSRPNEDTLGSQKRRRFSESPPSALQTSRSPRGGGFGSLLSGPEGLQPPRGAQGVRPLHPISRPRSGERPLPLGIRTLACSSSPICGGYRYHHNYAGDPSWAEDQEKEKEESYRQRRLKERERIGELGAPEVWGLSPKIPEPDSDEHTPAEDEVKNQKSSSSDFTNEEKRTKTSHSTKKKRKKKPSKRKHKKYYDSSSDCHSSSDSDKKKVKTKKKEKKKKHRAKQLKKKRTKKEYNDISCKASERDLPEDAWMEQSMSAESMDLIGPEAPVIHTSQDEKPLNYGHALLPGEGAAMAEYVKAGKRIPRRGEIGLTSEEIASFECSGYVMSGSRHRRMEAVRLRKENQIYSADEKRALASFNQEERRKRENKILASFREMVYRKTKGKDDK","sequence_length":395,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"2a23372252f4d36d9b43a8a9970f8230bb1a5a2df8e533c4f5ec229eee87e3d0","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q5SZT7.json","taxon_id":"10090","uniprot_accession":"Q5SZT7","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/nf-kappa-b-activating-protein-c-terminal-ipr009269.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR009269","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/nf-kappa-b-activating-protein-c-terminal-ipr009269.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/nkap-c-pf06047.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06047","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/nkap-c-pf06047.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/nkap-pf15692.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF15692","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/nkap-pf15692.yaml"}],"pfam_ids":["PF06047","PF15692"],"protein_name":"NF-kappa-B-activating protein","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAPVSGSRSPDREASGSGGRRRSSSKSPKPSKSARSPRGRRSRSHSCSRSGDRNGLTHQLGGLSQGSRNQSYRSRSRSRSRERPSAPRGIPFASASSSVYYGSYSRPYGSDKPWPSLLDKEREESLRQKRLSERERIGELGAPEVWGLSPKNPEPDSDEHTPVEDEEPKKSTTSASTSEEEKKKKSSRSKERSKKRRKKKSSKRKHKKYSEDSDSDSDSETDSSDEDNKRRAKKAKKKEKKKKHRSKKYKKKRSKKSRKESSDSSSKESQEEFLENPWKDRTKAEEPSDLIGPEAPKTLTSQDDKPLNYGHALLPGEGAAMAEYVKAGKRIPRRGEIGLTSEEIASFECSGYVMSGSRHRRMEAVRLRKENQIYSADEKRALASFNQEERRKRENKILASFREMVYRKTKGKDDK","sequence_length":415,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"cfebd875c0abb98c63585754d44c6503f385b471417fab90d927f46b2787842f","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q8N5F7.json","taxon_id":"9606","uniprot_accession":"Q8N5F7","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/nf-kappa-b-activating-protein-c-terminal-ipr009269.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR009269","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/nf-kappa-b-activating-protein-c-terminal-ipr009269.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/nkap-c-pf06047.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06047","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/nkap-c-pf06047.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/nkap-pf15692.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF15692","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/nkap-pf15692.yaml"}],"pfam_ids":["PF06047","PF15692"],"protein_name":"NF-kappa-B-activating protein","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAPVSGSRSPEREASGAKRRSPSRSPKSIKSSRSPRCRRSRSRSCSRFGDRNGLSHSLSGFSQSSRNQSYRSRSRSRSRERPSAQRSAPFASASSSAYYGGYSRPYGGDKPWPSLLDKEREESLRQKRLSERERIGELGAPEVWGLSPKNPEPDSDEHTPVEDEEPKKSTTSASSSEDDKKKKRKSSHSKDRAKKKRKKKSSKRKHKKYSEDSDSDSESDTDSSDEDSKRRAKKAKKKDKKKKRRGKKYKKKKSKKNRKESSDSSSKESQEEFLENPWKDRSKAEEPSDLIGPEAPKTLASQDDKPLNYGHALLPGEGAAMAEYVKAGKRIPRRGEIGLTSEEIASFECSGYVMSGSRHRRMEAVRLRKENQIYSADEKRALASFNQEERRKRENKILASFREMVYRKTKGKDDK","sequence_length":415,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"4bea203dad1ddc189070670db0f8fcf1d30ac885fb520e8a5bfa2d43a61e748a","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9D0F4.json","taxon_id":"10090","uniprot_accession":"Q9D0F4","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Drosophila melanogaster","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/nf-kappa-b-activating-protein-c-terminal-ipr009269.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR009269","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/nf-kappa-b-activating-protein-c-terminal-ipr009269.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/nkap-c-pf06047.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06047","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/nkap-c-pf06047.yaml"}],"pfam_ids":["PF06047"],"protein_name":"NF-kappa-B-activating protein","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MRSRSRSRSRQRERRRSDSRARSRSERRTYQKPQHRRSVSRERKRERDRELHRERTSNRSSRRSREKDAVPRRRRTRSSPSRSSSSSSSDRSSSSRSPSRSRKSRPKSVERWPNDRYHENNDRRQNPFRGRAPEGSFINDPAEPSFRSQHRGRGSSNHQFKGDSKAVNARRNQRVLIGEEGVPEVWGKSPSRPETDDVELVKGSYIGPKKKKKKGKRKHKKSEKKSKKKSKKSKKKKSKQESSSSSSSSSSEDSSDESSSSSSSSSSDSEDESEEEDVWLEKTADGIKKPKKKKSSTSKKDKKSKKKKKKRKSEAEKSKKSSSSSASKSKNKESASHNDEDVGPSLRPGGSLNQKDFGKALLPGEGAAMAAYIAEGKRIPRRGEIGLTSDEIANFESVGYVMSGSRHRRMEAVRIRKENQLYSADEKRALAMFSKEERQKRENKILSQFKDMIHSKLQAKDKK","sequence_length":463,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"6fd54fcae1133b2886ffeb42596025658456e3e50ac9dd004c79579d607d77f6","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9VB74.json","taxon_id":"7227","uniprot_accession":"Q9VB74","uniprot_release":"2026_03"}],"pfam_id":"PF06047","short_name":"Nkap_C","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}