{"cross_mech":[],"family":{"alphafold_models":3623,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This is a family of inositol-pentakisphosphate 2-kinases (EC 2.7.1.158) (also known as inositol 1,3,4,5,6-pentakisphosphate 2-kinase, Ins(1,3,4,5,6)P5 2-kinase) and InsP5 2-kinase). This enzyme phosphorylates Ins(1,3,4,5,6)P5 to form Ins(1,2,3,4,5,6)P6 (also known as InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, nonhomologous end-joining, endocytosis and ion channel regulation.","domain_architectures":88,"interpro_id":"IPR009286","known_evidence_count":null,"matches":4885,"name":"Inositol-pentakisphosphate 2-kinase","partial_evidence_count":null,"pfam_id":"PF06090","proteins":4299,"proteomes":3187,"short_name":"Ins_P5_2-kin","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06090","structures":23,"taxa":8450,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF06090.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":3623,"domain_architectures":88,"matches":4885,"proteins":4299,"proteomes":3187,"structures":23,"taxa":8450},"curation_status":"SEEDED","description":"This is a family of inositol-pentakisphosphate 2-kinases (EC 2.7.1.158) (also known as inositol 1,3,4,5,6-pentakisphosphate 2-kinase, Ins(1,3,4,5,6)P5 2-kinase) and InsP5 2-kinase). This enzyme phosphorylates Ins(1,3,4,5,6)P5 to form Ins(1,2,3,4,5,6)P6 (also known as InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, nonhomologous end-joining, endocytosis and ion channel regulation.","id":"Pfam:PF06090","interpro_id":"InterPro:IPR009286","name":"Inositol-pentakisphosphate 2-kinase","pfam_id":"PF06090","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"Ins_P5_2-kin","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06090"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF06090.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"708dcf4e1a2289b4364ce1f7d59b11a903ff8ed0025ccada85b35534e49a7447"}},"protein_examples":{"candidate_count":6,"discovery_scanned":true,"example_count":6,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","origins":[{"cited_uniprot_accession":"Q06667","commit":"e1c66917e753105c4bf5b7b026193fcefa2b000f","link_basis":["uniprot_pfam_xref"],"mech":"PathwayMech","path":"data/pathways/inositol-phosphate-biosynthesis.yaml","qualification_status":"NOT_ASSESSED","record_id":"gomodel:YeastPathways_PWY3O-402","section":"uniprot_accession","url":"https://github.com/CultureBotAI/PathwayMech/blob/e1c66917e753105c4bf5b7b026193fcefa2b000f/data/pathways/inositol-phosphate-biosynthesis.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/inositol-1-3-4-5-6-pentakisphosphate-2-kinase-activity-go0035299.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0035299","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/inositol-1-3-4-5-6-pentakisphosphate-2-kinase-activity-go0035299.yaml"}],"pfam_ids":["PF06090"],"protein_name":"Inositol-pentakisphosphate 2-kinase","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MQVIGRGGANILIDYGDPTWLWRCCIRWPDLLSSNNSYTIKNISYIKDYVEPLLHGLLCPMYLIDVDIEAIRPILSDFILNLDDKVVKVIKIKNLTNNTSNLILNNHFLKSYCSQNLQTVILELKPKWLYYDTDYCRNCTHNAFKGRGTKYCYNQLLMNPAHLELIFGECNIFPVKFKDAMHEYLRNDNNIFKILYDLQKKLTKNTTPISDIKSINDVNDEHLLLMTLRDVTCFIEWNSAENALHVNIIDVDLKPKEKWTHWTKTYSQLTSSQKIYHTSNK","sequence_length":281,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"d17b6631c880902a5b5ba7ece1633c26401333ee8ad2b5f551407c3b4b8a0553","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q06667.json","taxon_id":"559292","uniprot_accession":"Q06667","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Danio rerio","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/ins-p5-2-kin-pf06090.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06090","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/ins-p5-2-kin-pf06090.yaml"}],"pfam_ids":["PF06090"],"protein_name":"Inositol-pentakisphosphate 2-kinase","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MELDKMDENDWKYHGEGNKSIVVSHLRHCQVLRLLKVPSEDSAHTRQTAEQTLRHILNIMDYSKHVMKPLLGEKYVHSGEVVRLPLDFLRQMSLKVQQERPELRCDKVMDTFSGCGLCLPDLTQLPLHHLRDHRPPICVEIKPKCGFLPFSRHMTKECKWKVCRFCMHQHYKLANGKWKRLSRYCPLDLFSGSKQRMYVALKNLLEEPQNNLKIFKGGELIFSCKDDAKQQPDLNNLIQHLRPYFPHTNGLYNGHQPGKVILNEFIQVICSALLSGGDSNRSGEPRKMHLSESKPHCEASPFPRDLIRNGHHGLPKDSVLAKILQVQMLDNLDIEGIYPLYKRVEQYLEEFPKERIRLQIDGPYDESFMDTVKSCLNEDDGSVEYAIGKVHQYRVAMTAKDCSVMITFAPCEEDEEHKLNLEKPRFTYSVSILDLDTKPYEGIPHQYKLDSKIVNYYLRSTQAPPPSSLYKERQECTLLFHAV","sequence_length":483,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"2fabb737b6bddf36e31bd42e3921a8d001f86503d6d3f6a4c1c57ddc8df19d6e","sequence_version":3,"source_url":"https://rest.uniprot.org/uniprotkb/Q4JL91.json","taxon_id":"7955","uniprot_accession":"Q4JL91","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/inositol-1-3-4-5-6-pentakisphosphate-2-kinase-activity-go0035299.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0035299","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/inositol-1-3-4-5-6-pentakisphosphate-2-kinase-activity-go0035299.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/inositol-pentakisphosphate-2-kinase-n-terminal-lobe-ipr043001.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR043001","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/inositol-pentakisphosphate-2-kinase-n-terminal-lobe-ipr043001.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/inositol-pentakisphosphate-2-kinase-n-lobe-3-30-200-110.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:3.30.200.110","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/inositol-pentakisphosphate-2-kinase-n-lobe-3-30-200-110.yaml"}],"pfam_ids":["PF06090"],"protein_name":"Inositol-pentakisphosphate 2-kinase","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MEEGKMDENEWSYHGEGNKSLVVAHAQRCVVLRFLKFPPNKKKTSEEILQHLQNIVDFGKNVMKDFLGENYVHCGEVVQLPLEFVKQLCLKIQCERPESRCDKDLDTFSGYAMCLPNLTRLQTFHFAEHRPILCVEIKPKCGFIPFSNDVTHEMKHKVCRYCMHQHLKVATGKWKKISKYCPLDLYSGNKQRMHFALRSLLQETQNNLRIFKNGELIYGCGDARSPVADLKELAHHLKPFFFPSNGLASGPHCTKAVIRELVHVITRVLLSSSEKARAGALRLGLQGPRVCEASPFSRSLHNQGKNTSEHSGLPKGCLLYKTLQVQMLDQLDIEGLYPLYKRVEQYLEEFPEERKTLQIDGPYDEVFYQKLLDLSTEDDGTVAFALTKVQQYRVAMTAKDCSIMIALSPCLQGTSSDQRPVIPSSRSRLAFSVSVLDLDLKPYESIPHQYKLDSKIVNYYSKTVHAKDDTVRSTRFKEHEDCTLVLHKV","sequence_length":489,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"1e818239a855066c228812b84640d18498c9f5414d0b77e98504331047346047","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q6P1C1.json","taxon_id":"10090","uniprot_accession":"Q6P1C1","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Arabidopsis thaliana","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/inositol-1-3-4-5-6-pentakisphosphate-2-kinase-activity-go0035299.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0035299","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/inositol-1-3-4-5-6-pentakisphosphate-2-kinase-activity-go0035299.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/inositol-1-3-4-6-tetrakisphosphate-2-kinase-activity-go0102731.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0102731","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/inositol-1-3-4-6-tetrakisphosphate-2-kinase-activity-go0102731.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/inositol-1-4-5-6-tetrakisphosphate-2-kinase-activity-go0032942.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0032942","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/inositol-1-4-5-6-tetrakisphosphate-2-kinase-activity-go0032942.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/inositol-phosphate-biosynthetic-process-go0032958.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0032958","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/inositol-phosphate-biosynthetic-process-go0032958.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/intracellular-phosphate-ion-homeostasis-go0030643.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0030643","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/intracellular-phosphate-ion-homeostasis-go0030643.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/lateral-root-development-go0048527.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0048527","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/lateral-root-development-go0048527.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/myo-inositol-hexakisphosphate-biosynthetic-process-go0010264.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0010264","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/myo-inositol-hexakisphosphate-biosynthetic-process-go0010264.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/phosphate-ion-homeostasis-go0055062.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0055062","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/phosphate-ion-homeostasis-go0055062.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/ins-p5-2-kin-pf06090.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06090","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/ins-p5-2-kin-pf06090.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/inositol-pentakisphosphate-2-kinase-n-terminal-lobe-ipr043001.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR043001","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/inositol-pentakisphosphate-2-kinase-n-terminal-lobe-ipr043001.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/inositol-pentakisphosphate-2-kinase-n-lobe-3-30-200-110.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:3.30.200.110","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/inositol-pentakisphosphate-2-kinase-n-lobe-3-30-200-110.yaml"}],"pfam_ids":["PF06090"],"protein_name":"Inositol-pentakisphosphate 2-kinase","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MEMILEEKDASDWIYRGEGGANLVLAYAGSSPLFVGKVIRIQKARRNDKAIKNANGVVSVLTSDEQHLWRENNELISSPNKEVLEQRYVKNVIIPLLGPKHVDAGVRVSVSKEFLECVDKKVTKQRPLWRVNAANVDTSHDSALILNDHSLFSQGISSGGDCISVEIKPKCGFLPTSRFIGKENMLKTSVSRFKMHQLLKLEYNEISEESEYDPLDLFSGSKESVLEAIKALYSTPQNNFRVFLNGSLILGGSGESTGRTSPEIGYAFEDALKGFIQSEDGHRTECFLQLVSDAVYGSGVLDRLLEIQKLDKLDIEGAIHSYYDLINQPCPICKEGKPLEAELSLHALPLDESLKIVKEYLIAATAKDCSIMISFQSRNAWDSEPSGDYVSLKPTNQTFDYKVHFIDLSLKPLKRMESYYKLDKKIISFYNRKQKAENTAEQIGNSKPSHS","sequence_length":451,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"2f14bfedb5082dc12c8dc3cccbef8f5a622e85e9ef19095dda1558876338b61d","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q93YN9.json","taxon_id":"3702","uniprot_accession":"Q93YN9","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/inositol-1-3-4-5-6-pentakisphosphate-2-kinase-activity-go0035299.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0035299","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/inositol-1-3-4-5-6-pentakisphosphate-2-kinase-activity-go0035299.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/ins-p5-2-kin-pf06090.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06090","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/ins-p5-2-kin-pf06090.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/inositol-pentakisphosphate-2-kinase-n-terminal-lobe-ipr043001.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR043001","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/inositol-pentakisphosphate-2-kinase-n-terminal-lobe-ipr043001.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/inositol-pentakisphosphate-2-kinase-n-lobe-3-30-200-110.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:3.30.200.110","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/inositol-pentakisphosphate-2-kinase-n-lobe-3-30-200-110.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:Q9H8X2","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF06090"],"protein_name":"Inositol-pentakisphosphate 2-kinase","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"90bb9fb24b0162b8bef9da1b20cc5ac2dbf0d974453204f1dceb44e4c4ce2509","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MEEGKMDENEWGYHGEGNKSLVVAHAQRCVVLRFLKFPPNRKKTSEEIFQHLQNIVDFGKNVMKEFLGENYVHYGEVVQLPLEFVKQLCLKIQSERPESRCDKDLDTLSGYAMCLPNLTRLQTYRFAEHRPILCVEIKPKCGFIPFSSDVTHEMKHKVCRYCMHQHLKVATGKWKQISKYCPLDLYSGNKQRMHFALKSLLQEAQNNLKIFKNGELIYGCKDARSPVADWSELAHHLKPFFFPSNGLASGPHCTRAVIRELVHVITRVLLSGSDKGRAGTLSPGLGPQGPRVCEASPFSRSLRCQGKNTPERSGLPKGCLLYKTLQVQMLDLLDIEGLYPLYNRVERYLEEFPEERKTLQIDGPYDEAFYQKLLDLSTEDDGTVAFALTKVQQYRVAMTAKDCSIMIALSPCLQDASSDQRPVVPSSRSRFAFSVSVLDLDLKPYESIPHQYKLDGKIVNYYSKTVRAKDNAVMSTRFKESEDCTLVLHKV","sequence_length":491,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"90bb9fb24b0162b8bef9da1b20cc5ac2dbf0d974453204f1dceb44e4c4ce2509","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9H8X2.json","taxon_id":"9606","uniprot_accession":"Q9H8X2","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Drosophila melanogaster","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/inositol-1-3-4-5-6-pentakisphosphate-2-kinase-activity-go0035299.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0035299","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/inositol-1-3-4-5-6-pentakisphosphate-2-kinase-activity-go0035299.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/inositol-pentakisphosphate-2-kinase-n-terminal-lobe-ipr043001.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR043001","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/inositol-pentakisphosphate-2-kinase-n-terminal-lobe-ipr043001.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/inositol-pentakisphosphate-2-kinase-n-lobe-3-30-200-110.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:3.30.200.110","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/inositol-pentakisphosphate-2-kinase-n-lobe-3-30-200-110.yaml"}],"pfam_ids":["PF06090"],"protein_name":"Inositol-pentakisphosphate 2-kinase","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MTAERGPRSPGTGQKLRLRATEPMPQWTAKNLHALLDLPAAMELRQIELIYRAEGNANLVLALPQFKKVLRLPKMISSRLRQAAHQRHELADEVARPEGQRVSSERAGTENAGDLTMPDFMAYIGIMRRLLGNEFVCGADIVAIPKEDDRFWINEHIRAQRPVSRLDKEFVGPFGLLLPDVTQLPATFDVLLANLQAKGTTGDESGAAAGVGDGGGVGRGAGTRTKNRSAVRRLGDTYAIEIKPKQGWLQLASDVNDLFDLMPSGAVTKPKETTCNQEENEPSARDKCWCRFCSMQLLKMHNGKIKRLGHYCPLDLFSGTPSRMLDALDALLACPQNNLRVFQNSNLIYGDHANSISFDELSSRVFPGEIMVLIKHLLVACLLREYEHPESKRAEGSNQSQKQQQEQPEPEQLNQSRVSIAATETKAGAAGIGAANVVLPLGGRAAAPVVTAGQSSTRTRAAAATATTQRYTKVARVETTITRQAATSMAAGPASSSQLSGNVLATATATATATAMATSGRTETKTEPETPAEAASTTSRNVNQNESQKLNRNEPANQTQAQNNKTEIFRLPKNCVLQKILNLQLLVKVSQPIKLLPKLLSLCPFGFVYSACPPENLGNCR","sequence_length":621,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"d81c993a469a30a21362aebd833839014d931a01b01fe27c88839f5a02191f35","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q9W2Q7.json","taxon_id":"7227","uniprot_accession":"Q9W2Q7","uniprot_release":"2026_03"}],"pfam_id":"PF06090","short_name":"Ins_P5_2-kin","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}