{"cross_mech":[],"family":{"alphafold_models":3009,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This is the thioredoxin domain from in Thioredoxin domain-containing protein 17, also known as TRP14, which is a highly conserved and ubiquitously expressed oxidoreductase involved in controlling of cellular redox signalling pathways [[cite:PUB00032290]]. This domain is also found at the C-terminal of Acireductone dioxygenase (ARD) from Leishmania.","domain_architectures":65,"interpro_id":"IPR010357","known_evidence_count":null,"matches":3610,"name":"Thioredoxin domain-containing protein 17-like, thioredoxin domain","partial_evidence_count":null,"pfam_id":"PF06110","proteins":3438,"proteomes":2533,"short_name":"TXD17-like_Trx","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06110","structures":6,"taxa":7078,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF06110.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":3009,"domain_architectures":65,"matches":3610,"proteins":3438,"proteomes":2533,"structures":6,"taxa":7078},"curation_status":"SEEDED","description":"This is the thioredoxin domain from in Thioredoxin domain-containing protein 17, also known as TRP14, which is a highly conserved and ubiquitously expressed oxidoreductase involved in controlling of cellular redox signalling pathways [[cite:PUB00032290]]. This domain is also found at the C-terminal of Acireductone dioxygenase (ARD) from Leishmania.","id":"Pfam:PF06110","interpro_id":"InterPro:IPR010357","name":"Thioredoxin domain-containing protein 17-like, thioredoxin domain","pfam_id":"PF06110","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"TXD17-like_Trx","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06110"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF06110.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"49d8372272712baf4d9f22f867b28a69660bd0e25e936b60be2d24fe1d5064d4"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/cdd/human-trx-related-protein-14-trp14-like-family-composed-of-proteins-si-cd02952.yaml","qualification_status":"NOT_ASSESSED","record_id":"CDD:cd02952","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/cdd/human-trx-related-protein-14-trp14-like-family-composed-of-proteins-si-cd02952.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/thioredoxin-domain-containing-protein-17-like-domain-ipr010357.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR010357","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/thioredoxin-domain-containing-protein-17-like-domain-ipr010357.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/txd17-like-trx-pf06110.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06110","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/txd17-like-trx-pf06110.yaml"}],"pfam_ids":["PF06110"],"protein_name":"Thioredoxin domain-containing protein 17","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MARYEEVSVSGFEEFHRAVEQHNGKTIFAYFTGSKDAGGKSWCPDCVQAEPVVREGLKHISEGCVFIYCQVGEKPYWKDPNNDFRKNLKVTAVPTLLKYGTPQKLVESECLQANLVEMLFSED","sequence_length":123,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"84e24da1b0033317e65a63c27d0af425041d6250c2b7d65ee075853005a853cb","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9BRA2.json","taxon_id":"9606","uniprot_accession":"Q9BRA2","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/cdd/human-trx-related-protein-14-trp14-like-family-composed-of-proteins-si-cd02952.yaml","qualification_status":"NOT_ASSESSED","record_id":"CDD:cd02952","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/cdd/human-trx-related-protein-14-trp14-like-family-composed-of-proteins-si-cd02952.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/thioredoxin-domain-containing-protein-17-like-domain-ipr010357.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR010357","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/thioredoxin-domain-containing-protein-17-like-domain-ipr010357.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/txd17-like-trx-pf06110.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06110","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/txd17-like-trx-pf06110.yaml"}],"pfam_ids":["PF06110"],"protein_name":"Thioredoxin domain-containing protein 17","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MATFEEVSVLGFEEFDKAVKEHEGKTIFAYFSGSKDTEGKSWCPDCVEAEPVIREGLKHVTEDCVFIYCQVGDKPYWKDPNNDFRQKLKITAVPTLLKYGTPQKLVESECCQSSLVEMIFSED","sequence_length":123,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"766e2ad01f880832ade666c48dbf68974bc34d5801bb6ccfca9a0d5f95c6a808","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9CQM5.json","taxon_id":"10090","uniprot_accession":"Q9CQM5","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Arabidopsis thaliana","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/cdd/human-trx-related-protein-14-trp14-like-family-composed-of-proteins-si-cd02952.yaml","qualification_status":"NOT_ASSESSED","record_id":"CDD:cd02952","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/cdd/human-trx-related-protein-14-trp14-like-family-composed-of-proteins-si-cd02952.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/thioredoxin-domain-containing-protein-17-like-domain-ipr010357.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR010357","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/thioredoxin-domain-containing-protein-17-like-domain-ipr010357.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/txd17-like-trx-pf06110.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06110","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/txd17-like-trx-pf06110.yaml"}],"pfam_ids":["PF06110"],"protein_name":"Thioredoxin-like protein Clot","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MTLKKVDANPSTLESSLQELKSDETSRSKINFILFLADNDPTTGQSWCPDCVRAEPVIYKTLEEFPEEVKLIRAYAGDRPTWRTPAHPWRVDSRFKLTGVPTLVRWDGDSVKGRLEDHQAHLPHLILPLLAPST","sequence_length":134,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"1807f75035911c28b7d7cb69511a55d8a64eb9f91da3fe99045df24b7d897291","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9FMN4.json","taxon_id":"3702","uniprot_accession":"Q9FMN4","uniprot_release":"2026_03"}],"pfam_id":"PF06110","short_name":"TXD17-like_Trx","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}