{"cross_mech":[],"family":{"alphafold_models":13293,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This entry includes the catalytic domain of the protein ImmA, which is a metallopeptidase containing an HEXXH zinc-binding motif from peptidase family M78. ImmA is encoded on a conjugative transposon. Conjugating bacteria are able to transfer conjugative transposons that can, for example, confer resistance to antibiotics. The transposon is integrated into the chromosome, but during conjugation excises itself and then moves to the recipient bacterium and re-integrate into its chromosome. Typically a conjugative tranposon encodes only the proteins required for this activity and the proteins that regulate it. During exponential growth, the ICEBs1 transposon of Bacillus subtilis is inactivated by the immunity repressor protein ImmR, which is encoded by the transposon and represses the genes for excision and transfer. Cleavage of ImmR relaxes repression and allows transfer of the transposon. ImmA has been shown to be essential for the cleavage of ImmR [[cite:PUB00066798]]. This domain is also found in in metalloprotease IrrE, a central regulator of DNA damage repair in Deinococcaceae [[cite:PUB00051490]], HTH-type transcriptional regulators RamB [[cite:PUB00074928]] and PrpC [[cite:PUB00074929]].","domain_architectures":143,"interpro_id":"IPR010359","known_evidence_count":null,"matches":21261,"name":"IrrE N-terminal-like domain","partial_evidence_count":null,"pfam_id":"PF06114","proteins":21240,"proteomes":11259,"short_name":"Peptidase_M78","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06114","structures":10,"taxa":16625,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF06114.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":13293,"domain_architectures":143,"matches":21261,"proteins":21240,"proteomes":11259,"structures":10,"taxa":16625},"curation_status":"SEEDED","description":"This entry includes the catalytic domain of the protein ImmA, which is a metallopeptidase containing an HEXXH zinc-binding motif from peptidase family M78. ImmA is encoded on a conjugative transposon. Conjugating bacteria are able to transfer conjugative transposons that can, for example, confer resistance to antibiotics. The transposon is integrated into the chromosome, but during conjugation excises itself and then moves to the recipient bacterium and re-integrate into its chromosome. Typically a conjugative tranposon encodes only the proteins required for this activity and the proteins that regulate it. During exponential growth, the ICEBs1 transposon of Bacillus subtilis is inactivated by the immunity repressor protein ImmR, which is encoded by the transposon and represses the genes for excision and transfer. Cleavage of ImmR relaxes repression and allows transfer of the transposon. ImmA has been shown to be essential for the cleavage of ImmR [[cite:PUB00066798]]. This domain is also found in in metalloprotease IrrE, a central regulator of DNA damage repair in Deinococcaceae [[cite:PUB00051490]], HTH-type transcriptional regulators RamB [[cite:PUB00074928]] and PrpC [[cite:PUB00074929]].","id":"Pfam:PF06114","interpro_id":"InterPro:IPR010359","name":"IrrE N-terminal-like domain","pfam_id":"PF06114","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"Peptidase_M78","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06114"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF06114.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"399138ed7f9260f33acc38044faff469fe34f8bc6ecb6378b926dc51877a1436"}},"protein_examples":{"candidate_count":5,"discovery_scanned":true,"example_count":5,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Deinococcus deserti (strain DSM 17065 / CIP 109153 / LMG 22923 / VCD115)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/pattern/hth-laci-1.yaml","qualification_status":"NOT_ASSESSED","record_id":"PROSITE:PS00356","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/pattern/hth-laci-1.yaml"}],"pfam_ids":["PF06114"],"protein_name":"Radiation response metalloprotease IrrE","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MTDPAPPPTALAAAKARMRELAASYGAGLPGRDTHSLMHGLDGITLTFMPMGQRDGAYDPEHHVILINSQVRPERQRFTLAHEISHALLLGDDDLLSDLHDEYEGDRLEQVIETLCNVGAAALLMPAELIDDLLTRFGPTGRALAELARRADVSATSALYALAERTAPPVIYAVCALSRQEDEGEGGGAKELTVRASSASAGVKYSLSAGTPVPDDHPAALALDTRLPLAQDSYVPFRSGRRMPAYVDAFPERQRVLVSFALPAGRSEPDADKPEAPGDQS","sequence_length":281,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"6cb3835c251ab8635d6bf91fef97c431aa451d553f1b124e49b57d6c79875cfc","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/C1CZ84.json","taxon_id":"546414","uniprot_accession":"C1CZ84","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Bacillus subtilis (strain 168)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/irre-n-terminal-like-domain-ipr010359.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR010359","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/irre-n-terminal-like-domain-ipr010359.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/peptidase-m78-pf06114.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06114","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/peptidase-m78-pf06114.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/1-10-10-2910-1-10-10-2910.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:1.10.10.2910","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/1-10-10-2910-1-10-10-2910.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:P39780","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF06114"],"protein_name":"Phage-like element PBSX protein XkdA","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"d3eee2f2151530d5bb07342487f497e0028627dc9209818f91c4f5b4a42a3d95","sequence_version":4,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MGDYLSHLEEYVKNLYGRLGITSPHHIDMLKIAKDLDIWVHFEDMGSMMVKYDGMYSIVLNQKKSREEQWEDFGHELCHVLKHAGNHFQMNKLFRELQEFQANQFMYHFCVPTFMLLQMELPQWRSQALATIAAVFRVTKEFADKRLDMFERRKAGIQFQKRLAYLLSHKRPNAYEEGDQQHLQVAEEKALYHIGKNI","sequence_length":198,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"d3eee2f2151530d5bb07342487f497e0028627dc9209818f91c4f5b4a42a3d95","sequence_version":4,"source_url":"https://rest.uniprot.org/uniprotkb/P39780.json","taxon_id":"224308","uniprot_accession":"P39780","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Bacillus subtilis (strain 168)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/irre-n-terminal-like-domain-ipr010359.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR010359","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/irre-n-terminal-like-domain-ipr010359.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/peptidase-m78-pf06114.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06114","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/peptidase-m78-pf06114.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/1-10-10-2910-1-10-10-2910.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:1.10.10.2910","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/1-10-10-2910-1-10-10-2910.yaml"}],"pfam_ids":["PF06114"],"protein_name":"Uncharacterized protein YqaB","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MRYTNSHLEDWIENLYKKIDITEPEQINFERIAEALDIRLSFKPVTSFALKHSGIYNICLDSRKSRTEQWYDFAHEFCHIYRHEGDKKTMPATWTDYLDWQSNYFTYHFCIPTCMLRNINLPYIQSHAIENVAWLFKVSPSFAKKRLSIYYRKLTQHLFSQTVTGNLCPPFL","sequence_length":172,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"668f9ce173dc435efd43d676102722aa02445b9dcc81853654a5a0006209cb81","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P45899.json","taxon_id":"224308","uniprot_accession":"P45899","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Bacillus subtilis (strain 168)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/irre-n-terminal-like-domain-ipr010359.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR010359","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/irre-n-terminal-like-domain-ipr010359.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/peptidase-m78-pf06114.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06114","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/peptidase-m78-pf06114.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/1-10-10-2910-1-10-10-2910.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:1.10.10.2910","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/1-10-10-2910-1-10-10-2910.yaml"}],"pfam_ids":["PF06114"],"protein_name":"Metallopeptidase ImmA","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MITIYTSKGIKHKVQSVIKTHGTNNVYEICDIQKIYILKNDLGQANGLLQHDKATDQYLIHINENLQHQQFVIAHELGHYFLHKRLNTFKVVNCSKVLKDKLEHQASLFASELILTDKMLNEALPYIQGFSKEQIAAYFNVPSFVTDYKLSQIGSFSNRIYSHEISAFG","sequence_length":169,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"dccd8b8e242cb262dea84c0e71cf81ea97dbb23f49c059261cb4810c13ec008b","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P96630.json","taxon_id":"224308","uniprot_accession":"P96630","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.)","origins":[{"cited_uniprot_accession":"Q3J4E6","commit":"e1c66917e753105c4bf5b7b026193fcefa2b000f","link_basis":["uniprot_pfam_xref"],"mech":"PathwayMech","path":"data/pathways/ethylmalonyl-coa-pathway.yaml","qualification_status":"NOT_ASSESSED","record_id":"KEGG:M00373","section":"uniprot_accession","url":"https://github.com/CultureBotAI/PathwayMech/blob/e1c66917e753105c4bf5b7b026193fcefa2b000f/data/pathways/ethylmalonyl-coa-pathway.yaml"}],"pfam_ids":["PF01381","PF06114","PF09856"],"protein_name":"Propionyl-CoA carboxylase regulator","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAQKLYAGAKLRELRVKLGLTQKVFAERLGASLPYLNQMENNHRPVSATVVLALAQEFGVDVTKLTTSEAERIVTDMREALADPVFTDSPPLADLRLVASNAPAFARAFLDLHRAYRQTHERLASLDEALGRDEADLRPSPWEEVRDFFHYCDNYLDAVDRAAEHYAAPGGVRRDVFSAAMETLTRAGLDLQISDMPAIRSREGNALRLSARAAAPTQRFQLLHQVALLTQNDLLEATLDLARFQTAEAREIAKIGLANYFAGAALLPYRPFLQAAAETRHDLERLADLFGASIEQVAHRLSTLQRPGAKGVPFFFVRVDQAGTITKRHSATRFQFARFGGACPLWNVHRAFETPGRFLRQLAQTPDGVRYLLLARDVSKPGGSFTAPVRRYAIGLGCEVQHADALVYADGLDLKGSFEPIGISCRICDRQECHQRSVPPLEKRLRVDPDRRGLLPYEIVD","sequence_length":461,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"f60a89bf8b56520ee8811c0fbd8975f17040d3f4d1d56ab5885de8bf052a8cd4","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q3J4E6.json","taxon_id":"272943","uniprot_accession":"Q3J4E6","uniprot_release":"2026_03"}],"pfam_id":"PF06114","short_name":"Peptidase_M78","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}