{"cross_mech":[],"family":{"alphafold_models":6894,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family was formerly known as DUF1000. The full-length, Txnl1, protein which is a probable component of the 26S proteasome, uses its C-terminal, PITH, domain to associate specifically with the 26S proteasome. PITH derives from proteasome-interacting thioredoxin domain.","domain_architectures":170,"interpro_id":"IPR010400","known_evidence_count":null,"matches":8206,"name":"PITH domain","partial_evidence_count":null,"pfam_id":"PF06201","proteins":8085,"proteomes":3410,"short_name":"PITH","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06201","structures":9,"taxa":9033,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF06201.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":6894,"domain_architectures":170,"matches":8206,"proteins":8085,"proteomes":3410,"structures":9,"taxa":9033},"curation_status":"SEEDED","description":"This family was formerly known as DUF1000. The full-length, Txnl1, protein which is a probable component of the 26S proteasome, uses its C-terminal, PITH, domain to associate specifically with the 26S proteasome. PITH derives from proteasome-interacting thioredoxin domain.","id":"Pfam:PF06201","interpro_id":"InterPro:IPR010400","name":"PITH domain","pfam_id":"PF06201","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"PITH","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06201"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF06201.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"39c0c687d79d69124debf2ddb13379704698d01eb8875f666743770eb03002a5"}},"protein_examples":{"candidate_count":7,"discovery_scanned":true,"example_count":7,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/pith-pf06201.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06201","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/pith-pf06201.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:O43396","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF00085","PF06201"],"protein_name":"Thioredoxin-like protein 1","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"6c77c256418d8b1321ac4d5485798f66b40357c5be5f51e8bfd264aae644cd8f","sequence_version":3,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MVGVKPVGSDPDFQPELSGAGSRLAVVKFTMRGCGPCLRIAPAFSSMSNKYPQAVFLEVDVHQCQGTAATNNISATPTFLFFRNKVRIDQYQGADAVGLEEKIKQHLENDPGSNEDTDIPKGYMDLMPFINKAGCECLNESDEHGFDNCLRKDTTFLESDCDEQLLITVAFNQPVKLYSMKFQGPDNGQGPKYVKIFINLPRSMDFEEAERSEPTQALELTEDDIKEDGIVPLRYVKFQNVNSVTIFVQSNQGEEETTRISYFTFIGTPVQATNMNDFKRVVGKKGESH","sequence_length":289,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"6c77c256418d8b1321ac4d5485798f66b40357c5be5f51e8bfd264aae644cd8f","sequence_version":3,"source_url":"https://rest.uniprot.org/uniprotkb/O43396.json","taxon_id":"9606","uniprot_accession":"O43396","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/localization/go/sperm-cytoplasmic-droplet-go0097598.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0097598","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/localization/go/sperm-cytoplasmic-droplet-go0097598.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/penetration-of-cumulus-oophorus-go0061956.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0061956","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/penetration-of-cumulus-oophorus-go0061956.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/pith-domain-ipr010400.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR010400","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/pith-domain-ipr010400.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/pith-pf06201.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06201","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/pith-pf06201.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/pith-domain-superfamily-ipr037047.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR037047","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/pith-domain-superfamily-ipr037047.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/profile/pith.yaml","qualification_status":"NOT_ASSESSED","record_id":"PROSITE:PS51532","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/profile/pith.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/pith-domain-2-60-120-470.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:2.60.120.470","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/pith-domain-2-60-120-470.yaml"}],"pfam_ids":["PF06201"],"protein_name":"PITH domain-containing protein 1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSHGHSHGGGGCRCAAEREEPPEQRGLAYGLYLRIDLERLQCLNESREGSGRGVFKPWEERTDRSKFVESDADEELLFNIPFTGNVKLKGVIIMGEDDDSHPSEMRLYKNIPQMSFDDTEREPEQTFSLNRDITGELEYATKISRFSNVYHLSIHISKNFGADTTKIFYIGLRGEWTELRRHEVTICNYEASANPADHRVHQVTPQTHFIS","sequence_length":211,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"002f39fe4d2af88c261f6d82ef8f4c2f3f5a10fc1a37144dfb74389d093ad8d1","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q8BWR2.json","taxon_id":"10090","uniprot_accession":"Q8BWR2","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/pith-pf06201.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06201","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/pith-pf06201.yaml"}],"pfam_ids":["PF00085","PF06201"],"protein_name":"Thioredoxin-like protein 1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MVGVKPVGSDPDFQPELSGAGSRLAVVKFTMRGCGPCLRIAPAFSSMSNKYPQAVFLEVDVHQCQGTAATNNISATPTFLFFRNKVRIDQYQGADAVGLEEKIKQHLENDPGSNEDADIPKGYMDLMPFINKAGCECLNESDEHGFDNCLRKDMSFLESDCDEQLLITVAFNQPVKLYSMKFQGPDNGQGPKYVKIFINLPRSMDFEEAERSEPTQALELTEDDIKEDGIVPLRYVKFQNVNSVTLFVQSNQGEEETTRISYFTFIGTPVQATNMNDFKRVVGKKGESH","sequence_length":289,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"21d45ad2c187867ba78b00ee9f4ad221958964e282a1274d8d7b9c7ee29ec0a1","sequence_version":3,"source_url":"https://rest.uniprot.org/uniprotkb/Q8CDN6.json","taxon_id":"10090","uniprot_accession":"Q8CDN6","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Caenorhabditis elegans","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/pith-domain-ipr010400.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR010400","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/pith-domain-ipr010400.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/pith-pf06201.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06201","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/pith-pf06201.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/pith-domain-superfamily-ipr037047.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR037047","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/pith-domain-superfamily-ipr037047.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/profile/pith.yaml","qualification_status":"NOT_ASSESSED","record_id":"PROSITE:PS51532","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/profile/pith.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/pith-domain-2-60-120-470.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:2.60.120.470","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/pith-domain-2-60-120-470.yaml"}],"pfam_ids":["PF06201"],"protein_name":"PITH domain-containing protein ZK353.9","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MCSHGHSHNCAAEHIPEVPGDDVYRYDMVSYIDMEKVTTLNESVDGAGKKVFKVMEKRDDRLEYVESDCDHELLFNIPFTGHVRLTGLSIIGDEDGSHPAKIRLFKDREAMSFDDCSIEADQEIDLKQDPQGLVDYPLKASKFGNIHNLSILVDANFGEDETKIYYIGLRGEFQHEFRQRIAIATYESRAQLKDHKNEIPDAVAKGLF","sequence_length":208,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"b8729870346acee0e56348c5c640214ba66c1ee94c5d856e892bfa4d27ae804c","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q95ZI6.json","taxon_id":"6239","uniprot_accession":"Q95ZI6","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/localization/go/sperm-cytoplasmic-droplet-go0097598.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0097598","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/localization/go/sperm-cytoplasmic-droplet-go0097598.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/pith-domain-ipr010400.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR010400","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/pith-domain-ipr010400.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/pith-pf06201.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06201","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/pith-pf06201.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/pith-domain-superfamily-ipr037047.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR037047","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/pith-domain-superfamily-ipr037047.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/profile/pith.yaml","qualification_status":"NOT_ASSESSED","record_id":"PROSITE:PS51532","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/profile/pith.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/pith-domain-2-60-120-470.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:2.60.120.470","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/pith-domain-2-60-120-470.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:Q9GZP4","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF06201"],"protein_name":"PITH domain-containing protein 1","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"6b46783b9d0999f3c9c60783526a2b99a633cfdfaf57384abd949ca607e88894","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MSHGHSHGGGGCRCAAEREEPPEQRGLAYGLYLRIDLERLQCLNESREGSGRGVFKPWEERTDRSKFVESDADEELLFNIPFTGNVKLKGIIIMGEDDDSHPSEMRLYKNIPQMSFDDTEREPDQTFSLNRDLTGELEYATKISRFSNVYHLSIHISKNFGADTTKVFYIGLRGEWTELRRHEVTICNYEASANPADHRVHQVTPQTHFIS","sequence_length":211,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"6b46783b9d0999f3c9c60783526a2b99a633cfdfaf57384abd949ca607e88894","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9GZP4.json","taxon_id":"9606","uniprot_accession":"Q9GZP4","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Arabidopsis thaliana","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/pith-domain-ipr010400.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR010400","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/pith-domain-ipr010400.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/pith-pf06201.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06201","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/pith-pf06201.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/pith-domain-superfamily-ipr037047.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR037047","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/pith-domain-superfamily-ipr037047.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/profile/pith.yaml","qualification_status":"NOT_ASSESSED","record_id":"PROSITE:PS51532","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/profile/pith.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/pith-domain-2-60-120-470.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:2.60.120.470","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/pith-domain-2-60-120-470.yaml"}],"pfam_ids":["PF06201"],"protein_name":"PITH domain-containing protein At3g04780","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSAESASQIPKGQVDLLDFIDWSGVECLNQSSSHSLPNALKQGYREDEGLNLESDADEQLLIYIPFNQVIKLHSFAIKGPEEEGPKTVKFFSNKEHMCFSNVNDFPPSDTAELTEENLKGKPVVLKYVKFQNVRSLTIFIEANQSGSEVTKVQKIALYGSTVETTDMKGLKKIEDH","sequence_length":176,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"361737a6431c0e9a1fb8d14397591c3e820376297679c0adaf9bb6b0bfd65587","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q9SQZ9.json","taxon_id":"3702","uniprot_accession":"Q9SQZ9","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Drosophila melanogaster","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/regulation-of-macromolecule-metabolic-process-go0060255.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0060255","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/regulation-of-macromolecule-metabolic-process-go0060255.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/regulation-of-primary-metabolic-process-go0080090.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0080090","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/regulation-of-primary-metabolic-process-go0080090.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/pith-domain-ipr010400.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR010400","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/pith-domain-ipr010400.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/pith-pf06201.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06201","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/pith-pf06201.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/pith-domain-superfamily-ipr037047.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR037047","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/pith-domain-superfamily-ipr037047.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/profile/pith.yaml","qualification_status":"NOT_ASSESSED","record_id":"PROSITE:PS51532","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/profile/pith.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/pith-domain-2-60-120-470.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:2.60.120.470","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/pith-domain-2-60-120-470.yaml"}],"pfam_ids":["PF06201"],"protein_name":"PITH domain-containing protein CG6153","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MPHGHSHDHGGCSHEASDVDHALEMGIEYSLYTKIDLDNVECLNEETDGQGKSVFKPYEKRQDLSKYVESDADEELLFNIPFTGNIKLKGIIISGANDDSHPNMVKIFKNRPRMTFDDARAKPDQEFQLTRDARGEIEYSPKVVTFSSVHHLSLYFPSNFGEDITRIYYIGLRGEFTEAHYHGVTICNYESRANAADHKEKAFDGVGRAIQ","sequence_length":211,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"248bd3f8f8a468f76dffc69136d02ce905be96cba57ee110b74a23b81def8ef5","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9VK68.json","taxon_id":"7227","uniprot_accession":"Q9VK68","uniprot_release":"2026_03"}],"pfam_id":"PF06201","short_name":"PITH","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}