{"cross_mech":[],"family":{"alphafold_models":173,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"YdaT_toxin was first thought to be neutralised by the putative antitoxin YdaS ([pfam:PF15943]) [[cite:PUB00075651]] but recent studies showed that both YdaS and YdaT can act independently as toxins and are regulated by RacR [[cite:PUB00099919]].","domain_architectures":1,"interpro_id":"IPR009364","known_evidence_count":null,"matches":365,"name":"Bacterial toxin ydaT","partial_evidence_count":null,"pfam_id":"PF06254","proteins":365,"proteomes":270,"short_name":"YdaT_toxin","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06254","structures":2,"taxa":474,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF06254.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":173,"domain_architectures":1,"matches":365,"proteins":365,"proteomes":270,"structures":2,"taxa":474},"curation_status":"SEEDED","description":"YdaT_toxin was first thought to be neutralised by the putative antitoxin YdaS ([pfam:PF15943]) [[cite:PUB00075651]] but recent studies showed that both YdaS and YdaT can act independently as toxins and are regulated by RacR [[cite:PUB00099919]].","id":"Pfam:PF06254","interpro_id":"InterPro:IPR009364","name":"Bacterial toxin ydaT","pfam_id":"PF06254","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"YdaT_toxin","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06254"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF06254.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"4d70f6e317ea778b0e67da2ecc06bd08c968db021266f49a83ffa0fa31c4d338"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Escherichia coli (strain K12)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/ydat-toxin-pf06254.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06254","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/ydat-toxin-pf06254.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/transcriptional-regulator-ydat-like-superfamily-ipr037042.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR037042","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/transcriptional-regulator-ydat-like-superfamily-ipr037042.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/putative-bacterial-toxin-ydat-1-10-3600-10.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:1.10.3600.10","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/putative-bacterial-toxin-ydat-1-10-3600-10.yaml"}],"pfam_ids":["PF06254"],"protein_name":"Transcriptional regulator YdaT","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MKIKHEHIESVLFALAAEKGQAWVANAITEEYLRQGGGELPLVPGKDWNNQQNIYHRWLKGETKTQREKIQKLIPAILAILPRELRHRLCIFDTLERRALLAAQEALSTAIDAHDDAVQAVYRKAHFSGGGSSDDSVIVH","sequence_length":140,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"fdfeaf2c078ed2570ef724bc6e33b646328d5c8724cbec7b297ba3acb0f07297","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P76064.json","taxon_id":"83333","uniprot_accession":"P76064","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Escherichia coli (strain K12)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/ydat-toxin-pf06254.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06254","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/ydat-toxin-pf06254.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/transcriptional-regulator-ydat-like-superfamily-ipr037042.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR037042","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/transcriptional-regulator-ydat-like-superfamily-ipr037042.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/putative-bacterial-toxin-ydat-1-10-3600-10.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:1.10.3600.10","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/putative-bacterial-toxin-ydat-1-10-3600-10.yaml"}],"pfam_ids":["PF06254"],"protein_name":"Protein YdfX","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MKITPEQAREALDAWICRPGMTQEQATILITEAFWALKERPNIDVQRVTYEGGAIDQRALGVNRVKIFERWKAIDTRDKREKFTALVPAIMEATTG","sequence_length":96,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"a872d7826402677380388981b53335469a60474ea83bdf7a8125cf752a95809d","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P76165.json","taxon_id":"83333","uniprot_accession":"P76165","uniprot_release":"2026_03"}],"pfam_id":"PF06254","short_name":"YdaT_toxin","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
