{"cross_mech":[],"family":{"alphafold_models":6040,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family includes a domain found in lipopolysaccharide assembly protein A (LapA). LapA functions along with LapB in the assembly of lipopolysaccharide (LPS) [[cite:PUB00074284]]. Domains in this family are also found in some uncharacterised bacterial proteins.","domain_architectures":12,"interpro_id":"IPR010445","known_evidence_count":null,"matches":9195,"name":"Lipopolysaccharide assembly protein A domain","partial_evidence_count":null,"pfam_id":"PF06305","proteins":9195,"proteomes":8766,"short_name":"LapA_dom","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06305","structures":0,"taxa":12596,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF06305.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":6040,"domain_architectures":12,"matches":9195,"proteins":9195,"proteomes":8766,"structures":0,"taxa":12596},"curation_status":"SEEDED","description":"This family includes a domain found in lipopolysaccharide assembly protein A (LapA). LapA functions along with LapB in the assembly of lipopolysaccharide (LPS) [[cite:PUB00074284]]. Domains in this family are also found in some uncharacterised bacterial proteins.","id":"Pfam:PF06305","interpro_id":"InterPro:IPR010445","name":"Lipopolysaccharide assembly protein A domain","pfam_id":"PF06305","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"LapA_dom","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06305"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF06305.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"9ae824a5b78fc2faff93b2473e2dac27021c1f196a2240bed84a06110aca2062"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Bacillus subtilis (strain 168)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/lipopolysaccharide-assembly-protein-a-domain-ipr010445.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR010445","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/lipopolysaccharide-assembly-protein-a-domain-ipr010445.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/lapa-dom-pf06305.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06305","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/lapa-dom-pf06305.yaml"}],"pfam_ids":["PF06305"],"protein_name":"Uncharacterized protein YrvD","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MNKQWTIIFALIFTLIVAIFAVINVRSVEVDYLFGRSEWPLILVILGSVLMGALIVFSVGIFQVMKLKREIKTLRKENRTAIHKQEDTHLADQTDTQDASAMIEKKD","sequence_length":107,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"b7a449bebee344f116195bfb9337060dd46649c08b3d0b13ecb5b1805ac302d9","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/O32045.json","taxon_id":"224308","uniprot_accession":"O32045","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Escherichia coli (strain K12)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/lipopolysaccharide-metabolic-process-go0008653.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0008653","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/lipopolysaccharide-metabolic-process-go0008653.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/lipopolysaccharide-assembly-protein-a-domain-ipr010445.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR010445","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/lipopolysaccharide-assembly-protein-a-domain-ipr010445.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/lapa-dom-pf06305.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06305","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/lapa-dom-pf06305.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:P0ACV4","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF06305"],"protein_name":"Lipopolysaccharide assembly protein A","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"d8ba66d5963f0dd3d8f70851e1b46f0be6f1faeac58f48625e93c3a9794c817b","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MKYLLIFLLVLAIFVISVTLGAQNDQQVTFNYLLAQGEYRISTLLAVLFAAGFAIGWLICGLFWLRVRVSLARAERKIKRLENQLSPATDVAVVPHSSAAKE","sequence_length":102,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"d8ba66d5963f0dd3d8f70851e1b46f0be6f1faeac58f48625e93c3a9794c817b","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P0ACV4.json","taxon_id":"83333","uniprot_accession":"P0ACV4","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Shigella flexneri","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/lapa-dom-pf06305.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06305","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/lapa-dom-pf06305.yaml"}],"pfam_ids":["PF06305"],"protein_name":"Lipopolysaccharide assembly protein A","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MKYLLIFLLVLAIFVISVTLGAQNDQQVTFNYLLAQGEYRISTLLAVLFAAGFAIGWLICGLFWLRVRVSLARAERKIKRLENQLSPATDVAVVPHSSAAKE","sequence_length":102,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"d8ba66d5963f0dd3d8f70851e1b46f0be6f1faeac58f48625e93c3a9794c817b","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P0ACV5.json","taxon_id":"623","uniprot_accession":"P0ACV5","uniprot_release":"2026_03"}],"pfam_id":"PF06305","short_name":"LapA_dom","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
