{"cross_mech":[],"family":{"alphafold_models":214,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family consists of several insect proteins including protamine A (ProtA), protamine B (ProtB) and protamine-like protein 99C (Prtl99C) from Drosophila melanogaster. They contain a HMG-box and are involved in chromatin compaction during spermiogenesis [[cite:PUB00083892],[cite:PUB00083890]]. Prtl99C is a sperm chromatin-associated protein that is essential for male fertility [[cite:PUB00083890]].","domain_architectures":8,"interpro_id":"IPR024460","known_evidence_count":null,"matches":275,"name":"Protamine and protamine like","partial_evidence_count":null,"pfam_id":"PF06382","proteins":239,"proteomes":83,"short_name":"Protamine_like","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06382","structures":0,"taxa":372,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF06382.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":214,"domain_architectures":8,"matches":275,"proteins":239,"proteomes":83,"structures":0,"taxa":372},"curation_status":"SEEDED","description":"This family consists of several insect proteins including protamine A (ProtA), protamine B (ProtB) and protamine-like protein 99C (Prtl99C) from Drosophila melanogaster. They contain a HMG-box and are involved in chromatin compaction during spermiogenesis [[cite:PUB00083892],[cite:PUB00083890]]. Prtl99C is a sperm chromatin-associated protein that is essential for male fertility [[cite:PUB00083890]].","id":"Pfam:PF06382","interpro_id":"InterPro:IPR024460","name":"Protamine and protamine like","pfam_id":"PF06382","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"Protamine_like","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06382"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF06382.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"48a3d51a77b33bbcfce4a2f23389b9341215bb308a246a50d334e2452bf24069"}},"protein_examples":{"candidate_count":1,"discovery_scanned":true,"example_count":1,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Drosophila melanogaster","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/protamine-like-pf06382.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06382","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/protamine-like-pf06382.yaml"}],"pfam_ids":["PF06382"],"protein_name":"Protamine-like protein 99C","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MGRKRGRKEYCPPIYKRQKVARVTNNGYLNFMTEYKKRFYGLSPQDMVHYAAKQWTQLSMAEKEAFKSKKPSTITLKSPAQYVACEMKSDVAGGQQSSCQRQSPSARLRESERRSSRSKTLCRSAKNRQRGKPKPQQSKRRLSHMGSAVAYIHFLRKFQRKNTELRTIDLLKTATRLWCRLPERHRHAFERPLWIVTIGKS","sequence_length":201,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"09f9c34f99c85b03c5b5b175818e53b1e48ece5c851870db7aee433a8f012134","sequence_version":3,"source_url":"https://rest.uniprot.org/uniprotkb/Q9VAF7.json","taxon_id":"7227","uniprot_accession":"Q9VAF7","uniprot_release":"2026_03"}],"pfam_id":"PF06382","short_name":"Protamine_like","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
