{"cross_mech":[],"family":{"alphafold_models":2440,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"The FrsA-like family includes FrsA, an esterase found to have the alpha/beta-hydrolase fold [[cite:PUB00094022],[cite:PUB00094021],[cite:PUB00058796]]. t also includes the hydrolytic polyketide shortening protein Ayg1 from fungi [[cite:PUB00080691]], 2,6-dihydropseudooxynicotine hydrolase from Paenarthrobacter nicotinovorans [[cite:PUB00041915]] and Fus2 from Gibberella species [[cite:PUB00082317]]. The enzyme 2,6-dihydroxy-pseudo-oxynicotine hydrolase is involved in the nicotine-degradation pathway of Arthrobacter nicotinovorans [[cite:PUB00041915]]. Fus2 is part of the gene cluster that mediates the biosynthesis of the mycotoxin fusarin C. Fus2 catalyses closure of the 2-pyrrolidone ring of the intermediate 20-hydroxy-prefusarin to form another intermediate, 20-hydroxy-fusarin, which is then oxidized by Fus8 [[cite:PUB00082317]].","domain_architectures":25,"interpro_id":"IPR010520","known_evidence_count":null,"matches":3495,"name":"Esterase FrsA-like","partial_evidence_count":null,"pfam_id":"PF06500","proteins":3494,"proteomes":2667,"short_name":"FrsA-like","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06500","structures":15,"taxa":4571,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF06500.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":2440,"domain_architectures":25,"matches":3495,"proteins":3494,"proteomes":2667,"structures":15,"taxa":4571},"curation_status":"SEEDED","description":"The FrsA-like family includes FrsA, an esterase found to have the alpha/beta-hydrolase fold [[cite:PUB00094022],[cite:PUB00094021],[cite:PUB00058796]]. t also includes the hydrolytic polyketide shortening protein Ayg1 from fungi [[cite:PUB00080691]], 2,6-dihydropseudooxynicotine hydrolase from Paenarthrobacter nicotinovorans [[cite:PUB00041915]] and Fus2 from Gibberella species [[cite:PUB00082317]]. The enzyme 2,6-dihydroxy-pseudo-oxynicotine hydrolase is involved in the nicotine-degradation pathway of Arthrobacter nicotinovorans [[cite:PUB00041915]]. Fus2 is part of the gene cluster that mediates the biosynthesis of the mycotoxin fusarin C. Fus2 catalyses closure of the 2-pyrrolidone ring of the intermediate 20-hydroxy-prefusarin to form another intermediate, 20-hydroxy-fusarin, which is then oxidized by Fus8 [[cite:PUB00082317]].","id":"Pfam:PF06500","interpro_id":"InterPro:IPR010520","name":"Esterase 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