{"cross_mech":[],"family":{"alphafold_models":397,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"SPP is a family of signal-peptide aspartyl proteases. The family carries the characteristic catalytic aspartate GXGD motif, and members are integral membrane peptidases of the presenilin-type with nine transmembrane regions. UniProtKB:Q18K19 is part of the TCDB family 1.A.54.3.4, the presenilin er Ca(2+) leak channel (presenilin).","domain_architectures":3,"interpro_id":"IPR010545","known_evidence_count":null,"matches":449,"name":"Signal-peptide peptidase, presenilin aspartyl protease","partial_evidence_count":null,"pfam_id":"PF06550","proteins":425,"proteomes":405,"short_name":"SPP","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06550","structures":4,"taxa":710,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF06550.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":397,"domain_architectures":3,"matches":449,"proteins":425,"proteomes":405,"structures":4,"taxa":710},"curation_status":"SEEDED","description":"SPP is a family of signal-peptide aspartyl proteases. The family carries the characteristic catalytic aspartate GXGD motif, and members are integral membrane peptidases of the presenilin-type with nine transmembrane regions. UniProtKB:Q18K19 is part of the TCDB family 1.A.54.3.4, the presenilin er Ca(2+) leak channel (presenilin).","id":"Pfam:PF06550","interpro_id":"InterPro:IPR010545","name":"Signal-peptide peptidase, presenilin aspartyl protease","pfam_id":"PF06550","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"SPP","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06550"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF06550.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"65e43edb2b5107466747eeb2c5318b234fa4692686ebd2a56bccc83ce5c34d0e"}},"protein_examples":{"candidate_count":0,"discovery_scanned":true,"example_count":0,"examples":[],"pfam_id":"PF06550","short_name":"SPP","status":"NO_SIBLING_CANDIDATE","unresolved":[]}}
