{"cross_mech":[],"family":{"alphafold_models":92,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family is represented by Autographa californica nuclear polyhedrosis virus (AcMNPV) protein Ac75, which is required for the egress of nucleocapsids from the nucleus, formation of intranuclear microvesicles and subsequent budded virion formation, in addition to protein Ac93. Ac75 is not an integral membrane protein, but it interacts with integral membrane protein Ac76 and is associated with the nuclear membrane [[cite:PUB00089650]].","domain_architectures":1,"interpro_id":"IPR010594","known_evidence_count":null,"matches":99,"name":"Autographa californica nuclear polyhedrosis virus (AcMNPV), Ac75","partial_evidence_count":null,"pfam_id":"PF06648","proteins":99,"proteomes":97,"short_name":"AcMNPV_Ac75","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06648","structures":0,"taxa":196,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF06648.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":92,"domain_architectures":1,"matches":99,"proteins":99,"proteomes":97,"structures":0,"taxa":196},"curation_status":"SEEDED","description":"This family is represented by Autographa californica nuclear polyhedrosis virus (AcMNPV) protein Ac75, which is required for the egress of nucleocapsids from the nucleus, formation of intranuclear microvesicles and subsequent budded virion formation, in addition to protein Ac93. Ac75 is not an integral membrane protein, but it interacts with integral membrane protein Ac76 and is associated with the nuclear membrane [[cite:PUB00089650]].","id":"Pfam:PF06648","interpro_id":"InterPro:IPR010594","name":"Autographa californica nuclear polyhedrosis virus (AcMNPV), Ac75","pfam_id":"PF06648","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"AcMNPV_Ac75","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06648"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF06648.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"551d4b5858e442037dbe237ae14e2025e2a1bf21a3b2be68419c39f0b2a5794a"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Orgyia pseudotsugata multicapsid polyhedrosis virus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/acmnpv-ac75-pf06648.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06648","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/acmnpv-ac75-pf06648.yaml"}],"pfam_ids":["PF06648"],"protein_name":"Uncharacterized 14.9 kDa protein","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAGGLRGFVAELKKSTEFVAKVIFVKARLSDWLNSQVYPDERFSAKWRGVLKMFVDGQLDEESVYCLVNTIDPSKLLTVGQINYLARAFRNNRKMMSITQKFVDGYRLSDDDISELSNYLVAQVEEVYQL","sequence_length":130,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"90c95f14c5d350f5f5865fb61d6c3709d1aa25312f101ad8fc7056fe31a815f2","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/O10328.json","taxon_id":"262177","uniprot_accession":"O10328","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Lymantria dispar multicapsid nuclear polyhedrosis virus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/acmnpv-ac75-pf06648.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06648","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/acmnpv-ac75-pf06648.yaml"}],"pfam_ids":["PF06648"],"protein_name":"Uncharacterized 8.5 kDa protein in POL 3'region","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MDFFATFFNHVMTSMPVVTKVAYVSMHIKKYLKELERDDKFRDKLVRVLKLFIDKKITLDNMCAILDARTASG","sequence_length":73,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"83ec84be430f83914aa0c39b479c974792adbf698b5d338b5806017b9926106a","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P30326.json","taxon_id":"10449","uniprot_accession":"P30326","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Autographa californica nuclear polyhedrosis virus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/acmnpv-ac75-pf06648.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06648","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/acmnpv-ac75-pf06648.yaml"}],"pfam_ids":["PF06648"],"protein_name":"Protein Ac75","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSNLMKNFFTELVKSTTFTTKVSVVKTTLSNWLCEQVYPDKDFSLKLKRVVNMFLNNEIENNKIYKLVETVDSSNKLSRRQVDFLIHALLNNVSVTFTLHRFVDDNVLTQDELSFLANFLVTKMDEAYQLPAY","sequence_length":133,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"cf75646b5568d8e752cf2a836c588191024ccfa9d55c91a718c29ba9ca6dbf70","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q06669.json","taxon_id":"46015","uniprot_accession":"Q06669","uniprot_release":"2026_03"}],"pfam_id":"PF06648","short_name":"AcMNPV_Ac75","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}