{"cross_mech":[],"family":{"alphafold_models":252,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family represents MagC and related proteins that adopt an NlpC/P60-like fold but are catalytically inactive [[cite:PUB00164055]]. The structure consists of a six-stranded beta-sheet and five alpha-helices with a Cys-His-His catalytic triad characteristic of NlpC/P60 peptidases. However, a conserved tryptophan residue distorts the active site conformation, rendering these proteins unable to cleave peptidoglycan while retaining the ability to bind it [[cite:PUB00164055]]. In Pseudomonas aeruginosa, MagC is part of a type II alpha-2- macroglobulin complex encoded by the magABCDEF operon, where it directly interacts with the macroglobulin MagD [[cite:PUB00164055]]. These proteins are proposed to anchor the macroglobulin complex to the peptidoglycan layer in the bacterial periplasm [[cite:PUB00164055]].","domain_architectures":4,"interpro_id":"IPR009558","known_evidence_count":null,"matches":476,"name":"MagC peptidoglycan-binding NlpC/P60-like protein","partial_evidence_count":null,"pfam_id":"PF06672","proteins":436,"proteomes":430,"short_name":"MagC","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06672","structures":1,"taxa":664,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF06672.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":252,"domain_architectures":4,"matches":476,"proteins":436,"proteomes":430,"structures":1,"taxa":664},"curation_status":"SEEDED","description":"This family represents MagC and related proteins that adopt an NlpC/P60-like fold but are catalytically inactive [[cite:PUB00164055]]. The structure consists of a six-stranded beta-sheet and five alpha-helices with a Cys-His-His catalytic triad characteristic of NlpC/P60 peptidases. However, a conserved tryptophan residue distorts the active site conformation, rendering these proteins unable to cleave peptidoglycan while retaining the ability to bind it [[cite:PUB00164055]]. In Pseudomonas aeruginosa, MagC is part of a type II alpha-2- macroglobulin complex encoded by the magABCDEF operon, where it directly interacts with the macroglobulin MagD [[cite:PUB00164055]]. These proteins are proposed to anchor the macroglobulin complex to the peptidoglycan layer in the bacterial periplasm [[cite:PUB00164055]].","id":"Pfam:PF06672","interpro_id":"InterPro:IPR009558","name":"MagC peptidoglycan-binding NlpC/P60-like protein","pfam_id":"PF06672","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"MagC","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06672"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF06672.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"ee112df6e6143cd9b7a710a09d1aee779870d9883017eb3a862bab0b808947b8"}},"protein_examples":{"candidate_count":1,"discovery_scanned":true,"example_count":1,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Escherichia coli (strain K12)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/magc-pf06672.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06672","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/magc-pf06672.yaml"}],"pfam_ids":["PF06672"],"protein_name":"Uncharacterized protein YfaT","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MRHGLLALICWLCCVVAHSEMLNVEQSGLFRAWFVRIAQEQLRQGPSPRWYQQDCAGLVRFAANETLKVHDSKWLKSNGLSSQYLPPEMTLTPEQRQLAQNWNQGNGKTGPYVTAINLIQYNSQFIGQDINQALPGDMIFFDQGDAQHLMVWMGRYVIYHTGSATKTDNGMRAVSLQQLMTWKDTRWIPNDSNPNFIGIYRLNFLAR","sequence_length":207,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"b35bbff96973c128356ae67649e725603bf5150cf0cfed3c67fc9b3ad1af2663","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/P76466.json","taxon_id":"83333","uniprot_accession":"P76466","uniprot_release":"2026_03"}],"pfam_id":"PF06672","short_name":"MagC","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}