{"cross_mech":[],"family":{"alphafold_models":2297,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"SARAF is as family of eukaryotic proteins embedded in the ER. SARAF is SOCE-associated regulatory factor, where SOCE is store operated calcium entry. ie a mechanism governing calcium homoeostasis in the cell and the mitochondria. SOCE involves the enabling of Ca2+ release-activated Ca2+ (CRAC) channels. SARAF is a single pass ER membrane protein whose systolic-facing domain is responsible for activity and whose luminary-facing domain carries out a regulatory function in conjunction with another membrane protein STIM, an ER single pass membrane protein that detects changes in ER Ca2+ levels through its EF-hand, conserved Ca2+ binding domain. STIM is the major target for SARAF regulation, and thus SARAF negatively regulates the SOCE entry of calcium into cells protecting them from overfilling [[cite:PUB00075537]].","domain_architectures":44,"interpro_id":"IPR009567","known_evidence_count":null,"matches":2789,"name":"SOCE-associated regulatory factor of calcium homoeostasis","partial_evidence_count":null,"pfam_id":"PF06682","proteins":2681,"proteomes":2228,"short_name":"SARAF","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06682","structures":3,"taxa":5903,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF06682.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":2297,"domain_architectures":44,"matches":2789,"proteins":2681,"proteomes":2228,"structures":3,"taxa":5903},"curation_status":"SEEDED","description":"SARAF is as family of eukaryotic proteins embedded in the ER. SARAF is SOCE-associated regulatory factor, where SOCE is store operated calcium entry. ie a mechanism governing calcium homoeostasis in the cell and the mitochondria. SOCE involves the enabling of Ca2+ release-activated Ca2+ (CRAC) channels. SARAF is a single pass ER membrane protein whose systolic-facing domain is responsible for activity and whose luminary-facing domain carries out a regulatory function in conjunction with another membrane protein STIM, an ER single pass membrane protein that detects changes in ER Ca2+ levels through its EF-hand, conserved Ca2+ binding domain. STIM is the major target for SARAF regulation, and thus SARAF negatively regulates the SOCE entry of calcium into cells protecting them from overfilling [[cite:PUB00075537]].","id":"Pfam:PF06682","interpro_id":"InterPro:IPR009567","name":"SOCE-associated regulatory factor of calcium homoeostasis","pfam_id":"PF06682","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"SARAF","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06682"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF06682.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"701c1f483babf37d21b3af3c1f6c16c9dd154ee8437cbc534d0aa11e5698bd72"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/saraf-pf06682.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06682","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/saraf-pf06682.yaml"}],"pfam_ids":["PF06682"],"protein_name":"Store-operated calcium entry-associated regulatory factor","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAVAAVGRPRALRCPLLLLLSLLLVAGPALGWNDPDRILLRDVKALTLYSDRYTTSRRLDPIPQLKCVGGTAGCEAYTPRVIQCQNKGWDGYDVQWECKTDLDIAYKFGKTVVSCEGYESSEDQYVLRGSCGLEYNLDYTELGLKKLKESGKHQGFSDYYHKLYSSDSCGFITIAVLFVLAFAVYKLFLSDGQGSPPPYSEHPPYSEHSQRFASAAGAPPPGFKSEFTGPQNTGYGASSGFGSAFGGQGYGSSGPGFWSGLGAGGLLGYLFGSNRAATPFSDSWYHPAYPPSHSGAWNSRAYSPLGGGAGSYCASSNADSRTRTASGYGGTRRR","sequence_length":334,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"383cf4733adc2a9454aeefa7ae738b3d62d3100f501f20d57878cecbb1d5ea29","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q8R3Q0.json","taxon_id":"10090","uniprot_accession":"Q8R3Q0","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/saraf-pf06682.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06682","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/saraf-pf06682.yaml"}],"pfam_ids":["PF06682"],"protein_name":"Store-operated calcium entry-associated regulatory factor","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAAACGPGAAGYCLLLGLHLFLLTAGPALGWNDPDRMLLRDVKALTLHYDRYTTSRRLDPIPQLKCVGGTAGCDSYTPKVIQCQNKGWDGYDVQWECKTDLDIAYKFGKTVVSCEGYESSEDQYVLRGSCGLEYNLDYTELGLQKLKESGKQHGFASFSDYYYKWSSADSCNMSGLITIVVLLGIAFVVYKLFLSDGQYSPPPYSEYPPFSHRYQRFTNSAGPPPPGFKSEFTGPQNTGHGATSGFGSAFTGQQGYENSGPGFWTGLGTGGILGYLFGSNRAATPFSDSWYYPSYPPSYPGTWNRAYSPLHGGSGSYSVCSNSDTKTRTASGYGGTRRR","sequence_length":339,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"7253f691a776eaff9e5cf07689bf0930225cd8cb8b0e79ac0a5e2bc842472989","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q96BY9.json","taxon_id":"9606","uniprot_accession":"Q96BY9","uniprot_release":"2026_03"}],"pfam_id":"PF06682","short_name":"SARAF","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
