{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF06749","protein_label":"Protein DESIGUAL 3","reviewed":true,"short_name":"DUF1218","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/determination-of-bilateral-symmetry-go0009855.yaml","source_record_id":"GO:0009855","source_record_label":"determination of bilateral symmetry","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"A2RVQ4","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF06749","protein_label":"Protein VASCULATURE COMPLEXITY AND CONNECTIVITY","reviewed":true,"short_name":"DUF1218","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/determination-of-bilateral-symmetry-go0009855.yaml","source_record_id":"GO:0009855","source_record_label":"determination of bilateral symmetry","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"Q9ZV57","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF06749","protein_label":"Protein DESIGUAL 3","reviewed":true,"short_name":"DUF1218","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf1218-pf06749.yaml","source_record_id":"Pfam:PF06749","source_record_label":"Protein of unknown function (DUF1218)","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"A2RVQ4","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF06749","protein_label":"Protein MODIFYING WALL LIGNIN-1","reviewed":true,"short_name":"DUF1218","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf1218-pf06749.yaml","source_record_id":"Pfam:PF06749","source_record_label":"Protein of unknown function (DUF1218)","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"A2RVU1","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF06749","protein_label":"Protein VASCULATURE COMPLEXITY AND CONNECTIVITY","reviewed":true,"short_name":"DUF1218","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf1218-pf06749.yaml","source_record_id":"Pfam:PF06749","source_record_label":"Protein of unknown function (DUF1218)","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"Q9ZV57","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF06749","protein_label":"","reviewed":null,"short_name":"DUF1218","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf1218-pf06749.yaml","source_record_id":"Pfam:PF06749","source_record_label":"Protein of unknown function (DUF1218)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":5987,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function","description_says_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":3,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":2},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family contains hypothetical plant proteins of unknown function. Family members contain a number of conserved cysteine residues.","domain_architectures":80,"interpro_id":"IPR009606","known_evidence_count":null,"matches":7413,"name":"Protein of unknown function (DUF1218)","partial_evidence_count":null,"pfam_id":"PF06749","proteins":7332,"proteomes":383,"short_name":"DUF1218","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06749","structures":0,"taxa":1100,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF06749.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":5987,"domain_architectures":80,"matches":7413,"proteins":7332,"proteomes":383,"structures":0,"taxa":1100},"curation_status":"SEEDED","description":"This family contains hypothetical plant proteins of unknown function. Family members contain a number of conserved cysteine residues.","id":"Pfam:PF06749","interpro_id":"InterPro:IPR009606","name":"Protein of unknown function (DUF1218)","pfam_id":"PF06749","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF1218","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06749"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF06749.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"bad3b9a3fe3b1fafd80f41babc7c3c33ce0d939a8432067fa1234fa287648776"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Arabidopsis thaliana","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/determination-of-bilateral-symmetry-go0009855.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0009855","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/determination-of-bilateral-symmetry-go0009855.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf1218-pf06749.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06749","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf1218-pf06749.yaml"}],"pfam_ids":["PF06749"],"protein_name":"Protein DESIGUAL 3","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MESELGFLVSVVIICADITATVLGIEAEIAQSKAPHHHHQQHSRHSGSGCRRSPSDGAFAEGVAAMVLLFIVHVLANVLGGCTYIRSKQDFKRATANKILAVAFLVLSWIFFVVSYSTLMIGTLANSRTNRLCSLPHRWFFLIGGIFCLGHGVVTSAYYVSAIAAKKEDKENAQQENLANRSRA","sequence_length":184,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"e77825826b9e2c0af90e70177d62141504904b0b1b886ebe8137e39becdae559","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/A2RVQ4.json","taxon_id":"3702","uniprot_accession":"A2RVQ4","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Arabidopsis thaliana","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf1218-pf06749.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06749","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf1218-pf06749.yaml"}],"pfam_ids":["PF06749"],"protein_name":"Protein MODIFYING WALL LIGNIN-1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MFIFLFGLAAFFLCLSAEFQKAKALLRAQVFLKGKDLKWDGESCYLPENRAFGLGIAALVCVSVAQIVGNVVICRGFTKTDKTRTTIFCIILLLFSWVNFAVAVTLISVGASMNREQIYGKGWLNRECYLVKDGVFAASGFLSVTTMAAILGAFAFKVKPSLQVENHDKRHTQNV","sequence_length":175,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"eacb41bad8b88c5f2ca69f389e6d77a23dc0608f771dc7e3c14c09f4c7603ceb","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/A2RVU1.json","taxon_id":"3702","uniprot_accession":"A2RVU1","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Arabidopsis thaliana","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/determination-of-bilateral-symmetry-go0009855.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0009855","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/determination-of-bilateral-symmetry-go0009855.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf1218-pf06749.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06749","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf1218-pf06749.yaml"}],"pfam_ids":["PF06749"],"protein_name":"Protein VASCULATURE COMPLEXITY AND CONNECTIVITY","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MTKIGGILVCLVIVGLDVAAAILGIQAEVAQNQVKHMRLWLFECREPSQDAFRLGLGAAAILVMAHVLLNLVGGCLCICSQDEFQRSSSTRQISMACLVLTWIVFAVGFGSIVIGTMSNSKSRSSCGFTHHHFLSIGGILCFLHALFCVAYYVSATAAKDEAK","sequence_length":163,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"4c1124caff9c52becf237b5185d4650b6a56b6696ca62ea072a1629244da6480","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9ZV57.json","taxon_id":"3702","uniprot_accession":"Q9ZV57","uniprot_release":"2026_03"}],"pfam_id":"PF06749","short_name":"DUF1218","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}