{"cross_mech":[],"family":{"alphafold_models":244,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"CbtA is a family of bacterial and archaeal toxins of type IV toxin-antitoxin system. Toxins from such systems in free-living bacteria inhibit cell growth by targeting essential functions of cellular metabolism [[cite:PUB00086029]]. In this case the toxin inhibits cell-division leading to changes in morphology and finally lysis, by interacting with two essential cytoskeletal proteins, FtsZ and MreB. For FtsZ it inhibits its GTPase activity and GTP-dependent polymerisation, and for MreB it inhibits its ATP-dependent polymerisation. These actions of CbtA appear to occur simultaneously [[cite:PUB00075543]]. he cognate antitoxin family is represented by [pfam:PF06154].","domain_architectures":5,"interpro_id":"IPR009610","known_evidence_count":null,"matches":440,"name":"CbtA_toxin of type IV toxin-antitoxin system","partial_evidence_count":null,"pfam_id":"PF06755","proteins":440,"proteomes":252,"short_name":"CbtA_toxin","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06755","structures":0,"taxa":392,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF06755.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":244,"domain_architectures":5,"matches":440,"proteins":440,"proteomes":252,"structures":0,"taxa":392},"curation_status":"SEEDED","description":"CbtA is a family of bacterial and archaeal toxins of type IV toxin-antitoxin system. Toxins from such systems in free-living bacteria inhibit cell growth by targeting essential functions of cellular metabolism [[cite:PUB00086029]]. In this case the toxin inhibits cell-division leading to changes in morphology and finally lysis, by interacting with two essential cytoskeletal proteins, FtsZ and MreB. For FtsZ it inhibits its GTPase activity and GTP-dependent polymerisation, and for MreB it inhibits its ATP-dependent polymerisation. These actions of CbtA appear to occur simultaneously [[cite:PUB00075543]]. he cognate antitoxin family is represented by [pfam:PF06154].","id":"Pfam:PF06755","interpro_id":"InterPro:IPR009610","name":"CbtA_toxin of type IV toxin-antitoxin system","pfam_id":"PF06755","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"CbtA_toxin","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06755"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF06755.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"628e1a11f88cc780164bedbf87f0aa1f006b0892ae4b38d764731eac9dd089c8"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Escherichia coli (strain K12)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/autolysis-go0001896.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0001896","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/autolysis-go0001896.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/negative-regulation-of-cytoskeleton-organization-go0051494.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0051494","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/negative-regulation-of-cytoskeleton-organization-go0051494.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/negative-regulation-of-ftsz-dependent-cytokinesis-go2000245.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:2000245","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/negative-regulation-of-ftsz-dependent-cytokinesis-go2000245.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/cbta-toxin-pf06755.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06755","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/cbta-toxin-pf06755.yaml"}],"pfam_ids":["PF06755"],"protein_name":"Cytoskeleton-binding toxin CbtA","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGFSACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK","sequence_length":124,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"2b524328b9db0e4e4ea3e8b15548add68df24f29f35238bfea382c75c73bdf64","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P64524.json","taxon_id":"83333","uniprot_accession":"P64524","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Escherichia coli (strain K12)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/cbta-toxin-pf06755.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06755","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/cbta-toxin-pf06755.yaml"}],"pfam_ids":["PF06755"],"protein_name":"Toxin YkfI","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MKTLPAITQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGFSWQEQSPYLRAADILRARQATGLLRQSRNNVVR","sequence_length":113,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"a24f2e3de3471414246e7f7ddab3a75603270ecce0302ba44d3bf420b6ada6f3","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P77692.json","taxon_id":"83333","uniprot_accession":"P77692","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Escherichia coli (strain K12)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/cbta-toxin-pf06755.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06755","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/cbta-toxin-pf06755.yaml"}],"pfam_ids":["PF06755"],"protein_name":"Toxin YpjF","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGFSWQQQSPYISVVDILRARRSTGLLKTNVK","sequence_length":109,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"d0c44a9ff66a82734344fb29cbb654f01d4a583353ba328a3040e11d8461ca70","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q46953.json","taxon_id":"83333","uniprot_accession":"Q46953","uniprot_release":"2026_03"}],"pfam_id":"PF06755","short_name":"CbtA_toxin","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}