{"cross_mech":[],"family":{"alphafold_models":46,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This archaeal family includes the iron guanylylpyridinol (FeGP) cofactor biosynthesis protein HcgF which catalyses the transesterification of AMP-GP to afford a Cys (HcgF)-S-GP thioester [[cite:PUB00098596]].","domain_architectures":1,"interpro_id":"IPR009625","known_evidence_count":null,"matches":50,"name":"FeGP cofactor biosynthesis protein HcgF","partial_evidence_count":null,"pfam_id":"PF06787","proteins":50,"proteomes":46,"short_name":"HcgF","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06787","structures":3,"taxa":119,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF06787.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":46,"domain_architectures":1,"matches":50,"proteins":50,"proteomes":46,"structures":3,"taxa":119},"curation_status":"SEEDED","description":"This archaeal family includes the iron guanylylpyridinol (FeGP) cofactor biosynthesis protein HcgF which catalyses the transesterification of AMP-GP to afford a Cys (HcgF)-S-GP thioester [[cite:PUB00098596]].","id":"Pfam:PF06787","interpro_id":"InterPro:IPR009625","name":"FeGP cofactor biosynthesis protein HcgF","pfam_id":"PF06787","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"HcgF","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06787"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF06787.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"e6b6cbd3c15db1f597e4eb588106800ab570e3a2481c98ec23cb25eeb4190311"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/hcgf-pf06787.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06787","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/hcgf-pf06787.yaml"}],"pfam_ids":["PF06787"],"protein_name":"Iron-guanylylpyridinol cofactor biosynthesis protein HcgF","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MISVATLECFTHGKIGIKIHKMACGYKELQNDFGYDIIRGNVLVTASMFLPSKESIESLLNMKLPKSDHEFKYSKAYNEENDLKVAEYISKALKEKLKCNIAISTTAGVGKGAISILTDKNSYLFTSDIYGNLIKGENILKRQENAVNKAFEAFIKILNEEYNIKE","sequence_length":166,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"a2bb57d08e26d9e97053c10d432ebf2869a676238a4aed47140d391f692bc2c4","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/A6UNU1.json","taxon_id":"406327","uniprot_accession":"A6UNU1","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/hcgf-pf06787.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06787","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/hcgf-pf06787.yaml"}],"pfam_ids":["PF06787"],"protein_name":"Iron-guanylylpyridinol cofactor biosynthesis protein HcgF","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MITVATAECFTLGKIGTTIHKIASGYEECKNHRYYNIINGNVKIISSSFIPSIEGAEKLLNLGAPLPKCDYEYSYSKAYTEKNDLKVAHILAKGLKNSLNCNIAIATTAGVGRGGICIISDKNEYLFTTDIEGDLISKKNIIQRQKNGIDKTINKFVEILKKEYFL","sequence_length":166,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"16e7b645f3b947685ecf0b8989334fb15175f29057a46834e48f7374cfa97c13","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/A6UUT0.json","taxon_id":"419665","uniprot_accession":"A6UUT0","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/protein_family/ncbifam/hypothetical-protein-nf002122.yaml","qualification_status":"NOT_ASSESSED","record_id":"NCBIfam:NF002122","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/protein_family/ncbifam/hypothetical-protein-nf002122.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/hcgf-pf06787.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06787","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/hcgf-pf06787.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:Q58649","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF06787"],"protein_name":"Iron-guanylylpyridinol cofactor biosynthesis protein HcgF","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"237e396615ebf966e2f49f71f81b43244f161af6883e7eb1852a4285b856a8f0","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MITVATAECFTHANIGLTIHKAAAGYEDFEFKYLFSEEDLKLMKNVRVISAMFVPSIIGVEKLLDIKLPEPDFNYKYAKAYSEEKDLEVAKLMAEGLKKKLNVNISIGSTAGVGRGAICILTDNNRYLFTSDVYANLITFENIKERQKNGIEKGIKRFLEILKKEYF","sequence_length":167,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"237e396615ebf966e2f49f71f81b43244f161af6883e7eb1852a4285b856a8f0","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q58649.json","taxon_id":"243232","uniprot_accession":"Q58649","uniprot_release":"2026_03"}],"pfam_id":"PF06787","short_name":"HcgF","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}