{"cross_mech":[],"family":{"alphafold_models":5980,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family consists of several related groups of proteins one of which is the LptC family. LptC is involved in lipopolysaccharide-assembly on the outer membrane of Gram-negative organisms. The lipopolysaccharide component of the outer bacterial membrane is transported form its source of origin to the outer membrane by a set of proteins constituting a transport machinery that is made up of LptA, LptB, LptC, LptD, LptE. LptC is located on the inner membrane side of the intermembrane space.","domain_architectures":21,"interpro_id":"IPR010664","known_evidence_count":null,"matches":9337,"name":"Lipopolysaccharide-assembly, LptC-related","partial_evidence_count":null,"pfam_id":"PF06835","proteins":9054,"proteomes":8934,"short_name":"LptC","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06835","structures":8,"taxa":12986,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF06835.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":5980,"domain_architectures":21,"matches":9337,"proteins":9054,"proteomes":8934,"structures":8,"taxa":12986},"curation_status":"SEEDED","description":"This family consists of several related groups of proteins one of which is the LptC family. LptC is involved in lipopolysaccharide-assembly on the outer membrane of Gram-negative organisms. The lipopolysaccharide component of the outer bacterial membrane is transported form its source of origin to the outer membrane by a set of proteins constituting a transport machinery that is made up of LptA, LptB, LptC, LptD, LptE. LptC is located on the inner membrane side of the intermembrane space.","id":"Pfam:PF06835","interpro_id":"InterPro:IPR010664","name":"Lipopolysaccharide-assembly, LptC-related","pfam_id":"PF06835","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"LptC","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06835"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF06835.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"09809b65cac919cc5cdd61b7dba761b23bfcab481ef515b936421b5167cc3af6"}},"protein_examples":{"candidate_count":1,"discovery_scanned":true,"example_count":1,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Escherichia coli (strain K12)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/localization/go/transporter-complex-go1990351.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:1990351","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/localization/go/transporter-complex-go1990351.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/glycolipid-transfer-activity-go0017089.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0017089","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/glycolipid-transfer-activity-go0017089.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/lipopolysaccharide-transmembrane-transporter-activity-go0015221.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0015221","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/lipopolysaccharide-transmembrane-transporter-activity-go0015221.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/gram-negative-bacterium-type-cell-outer-membrane-assembly-go0043165.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0043165","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/gram-negative-bacterium-type-cell-outer-membrane-assembly-go0043165.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/lipopolysaccharide-transport-go0015920.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0015920","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/lipopolysaccharide-transport-go0015920.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/protein_family/ncbifam/lps-export-abc-transporter-periplasmic-protein-lptc-nf008142.yaml","qualification_status":"NOT_ASSESSED","record_id":"NCBIfam:NF008142","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/protein_family/ncbifam/lps-export-abc-transporter-periplasmic-protein-lptc-nf008142.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/protein_family/ncbifam/lps-export-abc-transporter-periplasmic-protein-lptc-tigr04409.yaml","qualification_status":"NOT_ASSESSED","record_id":"NCBIfam:TIGR04409","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/protein_family/ncbifam/lps-export-abc-transporter-periplasmic-protein-lptc-tigr04409.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/lptc-pf06835.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06835","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/lptc-pf06835.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/lipopolysaccharide-lps-transport-protein-a-like-domain-2-60-450-10.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:2.60.450.10","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/lipopolysaccharide-lps-transport-protein-a-like-domain-2-60-450-10.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:P0ADV9","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF06835"],"protein_name":"Lipopolysaccharide export system protein LptC","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"fda185c7d70ddca93f887882dfb16457ba13b28ee168af4c4cf991437d6b5631","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MSKARRWVIIVLSLAVLVMIGINMAEKDDTAQVVVNNNDPTYKSEHTDTLVYNPEGALSYRLIAQHVEYYSDQAVSWFTQPVLTTFDKDKIPTWSVKADKAKLTNDRMLYLYGHVEVNALVPDSQLRRITTDNAQINLVTQDVTSEDLVTLYGTTFNSSGLKMRGNLRSKNAELIEKVRTSYEIQNKQTQP","sequence_length":191,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"fda185c7d70ddca93f887882dfb16457ba13b28ee168af4c4cf991437d6b5631","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P0ADV9.json","taxon_id":"83333","uniprot_accession":"P0ADV9","uniprot_release":"2026_03"}],"pfam_id":"PF06835","short_name":"LptC","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}