{"cross_mech":[],"family":{"alphafold_models":5002,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This domain is found in mitochondrial proteins, including FAM210A and B, which contains a transmembrane peptide [[cite:PUB00097753],[cite:PUB00097752],[cite:PUB00097751]]. Its function is not clear. FAM210A, a protein essential in maintaining skeletal muscle structure and strength [[cite:PUB00097754]], interacts with mitochondrial translation elongation factor EF-Tu and promotes mitochondrial protein expression. In FAM210A, this domain is responsible for binding EF-Tu [[cite:PUB00097751]]. FAM210B plays a role in erythroid differentiation and is involved in cell proliferation and tumour cell growth suppression [[cite:PUB00097753],[cite:PUB00097755]].","domain_architectures":81,"interpro_id":"IPR009688","known_evidence_count":null,"matches":5823,"name":"FAM210A/B-like domain","partial_evidence_count":null,"pfam_id":"PF06916","proteins":5800,"proteomes":3286,"short_name":"FAM210A-B_dom","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06916","structures":0,"taxa":8695,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF06916.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":5002,"domain_architectures":81,"matches":5823,"proteins":5800,"proteomes":3286,"structures":0,"taxa":8695},"curation_status":"SEEDED","description":"This domain is found in mitochondrial proteins, including FAM210A and B, which contains a transmembrane peptide [[cite:PUB00097753],[cite:PUB00097752],[cite:PUB00097751]]. Its function is not clear. FAM210A, a protein essential in maintaining skeletal muscle structure and strength [[cite:PUB00097754]], interacts with mitochondrial translation elongation factor EF-Tu and promotes mitochondrial protein expression. In FAM210A, this domain is responsible for binding EF-Tu [[cite:PUB00097751]]. FAM210B plays a role in erythroid differentiation and is involved in cell proliferation and tumour cell growth suppression [[cite:PUB00097753],[cite:PUB00097755]].","id":"Pfam:PF06916","interpro_id":"InterPro:IPR009688","name":"FAM210A/B-like domain","pfam_id":"PF06916","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"FAM210A-B_dom","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF06916"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF06916.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"19835677b2ce1b6e28fc23f7643e2da20af24c5b0e766d0c6f0fe30fe9f43467"}},"protein_examples":{"candidate_count":5,"discovery_scanned":true,"example_count":5,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/n-terminal-peptidyl-methionine-acetylation-go0017196.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0017196","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/n-terminal-peptidyl-methionine-acetylation-go0017196.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/protein-fam210a-b-like-domain-ipr009688.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR009688","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/protein-fam210a-b-like-domain-ipr009688.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:P37293","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF06916"],"protein_name":"Putative N-terminal acetyltransferase 2","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"d5ab07d5d0ae8b879a79f983d52a9c5c9e84fbafed62baa4b1711a4ada922446","sequence_version":2,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MMVPRISASPVFKRIFLRWGFVTLPIQKTVSHTLRRDFSAPCRSMVKCLLLRPGISVHSAQDRKFYSTEEKSSQFDENKSKSNNGKKNEPHGIKGLMAKYGYSALIVYILLTCVDLPLCFLGVHSLGEEKIKIYLNRGKQLIGMGEPDESKVIQDVRRKQAHREAVQAENADKVEDASRKTFNERWQEMKDSTLLAELLIAYGIHKSLIIVRVPLTAVLTPSFVKLLQRFGIDLMKKQKKVFQTMASGAKIRYKGNNPSDFIKNEGTALDITKRKPRTKGQKWFDGLM","sequence_length":288,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"d5ab07d5d0ae8b879a79f983d52a9c5c9e84fbafed62baa4b1711a4ada922446","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/P37293.json","taxon_id":"559292","uniprot_accession":"P37293","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/protein-fam210a-b-like-domain-ipr009688.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR009688","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/protein-fam210a-b-like-domain-ipr009688.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/fam210a-b-dom-pf06916.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06916","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/fam210a-b-dom-pf06916.yaml"}],"pfam_ids":["PF06916"],"protein_name":"Mitochondrial inner membrane scaffold 1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MQWNVPRTMSRLALRTFVEAQKARLFDHHWRIKGPLLVHRGEYRVAWTPHLRKQWLHLSAVQCLAKQRNLLDAQPPQLGTLRQERWEQDILSKRVLSSSSTSQETPSEKKEETDPLQDKSISLYQRFKKTFRQYGKVLIPVHLITSGIWFGTFYYATIKGVNVIPFLEVIGLPDSIVDILKNSQSGNALTAYAMFKIATPARYTVTLGGTSFTVKYLRSHGYMSTPPPVKEYLQGRMEETKELITEKMEETKDRLTEKLQETKGKVSFKKKVE","sequence_length":273,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"7a182a17d7ca16fa18f39c6f01f54678820d66bf3c3987b7f0589cdf69229409","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q8BGY7.json","taxon_id":"10090","uniprot_accession":"Q8BGY7","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/protein-fam210a-b-like-domain-ipr009688.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR009688","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/protein-fam210a-b-like-domain-ipr009688.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/fam210a-b-dom-pf06916.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06916","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/fam210a-b-dom-pf06916.yaml"}],"pfam_ids":["PF06916"],"protein_name":"Mitochondrial inner membrane scaffold 2","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAGLLALLGPAGRVGARVRPRATWLLGATAPCAPPPLALALLPPRLDARLLRTARGDCRGHQDPSQATGTTGSSVSCTEEKKQSKSQQLKKIFQEYGTVGVSLHIGISLISLGIFYMVVSSGVDMPAILLKLGFKESLVQSKMAAGTSTFVVAYAIHKLFAPVRISITLVSVPLIVRYFRKVGFFKPPAAKP","sequence_length":192,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"fe8508e2c591adfff259d8e8ba83fb0b7513c35e4f1ca34315b646b7a5dff3f8","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q96KR6.json","taxon_id":"9606","uniprot_accession":"Q96KR6","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/protein-fam210a-b-like-domain-ipr009688.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR009688","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/protein-fam210a-b-like-domain-ipr009688.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/6-10-140-1430-6-10-140-1430.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:6.10.140.1430","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/6-10-140-1430-6-10-140-1430.yaml"}],"pfam_ids":["PF06916"],"protein_name":"Mitochondrial inner membrane scaffold 1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MQWNVPRTVSRLARRTCLEPHNAGLFGHCQNVKGPLLLYNAESKVVLVQGPQKQWLHLSAAQCVAKERRPLDAHPPQPGVLRHKQGKQHVSFRRVFSSSATAQGTPEKKEEPDPLQDKSISLYQRFKKTFRQYGKVLIPVHLITSGVWFGTFYYAALKGVNVVPFLELIGLPDSVVSILKNSQSGNALTAYALFKIATPARYTVTLGGTSVTVKYLRSHGYMSTPPPVKEYLQDRMEETKELITEKMEETKDRLTEKLQETKEKVSFKKKVE","sequence_length":272,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"8e5117b619520438af9a49b13ba1cb258af5b6496e767f234661da9f5d14cf91","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q96ND0.json","taxon_id":"9606","uniprot_accession":"Q96ND0","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/protein-fam210a-b-like-domain-ipr009688.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR009688","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/protein-fam210a-b-like-domain-ipr009688.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/fam210a-b-dom-pf06916.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF06916","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/fam210a-b-dom-pf06916.yaml"}],"pfam_ids":["PF06916"],"protein_name":"Mitochondrial inner membrane scaffold 2","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAGLLTLLGPAGRVSTRLRPLAPWLLGTATSCAPPLWALALSHPVPDARLLRTARGDCLSRQEPNRTPEPGGSVTGTEKKLSRTQQLKKVFQEYGAVGVSMHIGISLVSLGIFYTVVSSGIDMSAILLKLGFKESLVQSKMAAGTSTFVVAYAIHKLFAPVRISITLVSVPFVVRYFRSVGLFKPPATKP","sequence_length":190,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"132597dead6f3f7a7a3f3ded764af545b8d433eb6e77d73e3cf6a41dd8f6854d","sequence_version":3,"source_url":"https://rest.uniprot.org/uniprotkb/Q9D8B6.json","taxon_id":"10090","uniprot_accession":"Q9D8B6","uniprot_release":"2026_03"}],"pfam_id":"PF06916","short_name":"FAM210A-B_dom","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
