{"cross_mech":[],"family":{"alphafold_models":2549,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This entry (ex DUF1345) represents BPSS1818, a virulence factor required for full Burkholderia pseudomallei pathogenesis in vivo. BPSS1818 is involved in indirect modulation of mammalian host cell tubulin, probably in concert with other bacterial components [[cite:PUB00159059]].","domain_architectures":4,"interpro_id":"IPR009781","known_evidence_count":null,"matches":4178,"name":"Virulence factor BPSS1818","partial_evidence_count":null,"pfam_id":"PF07077","proteins":4176,"proteomes":3794,"short_name":"BPSS1818","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07077","structures":0,"taxa":5000,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF07077.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":2549,"domain_architectures":4,"matches":4178,"proteins":4176,"proteomes":3794,"structures":0,"taxa":5000},"curation_status":"SEEDED","description":"This entry (ex DUF1345) represents BPSS1818, a virulence factor required for full Burkholderia pseudomallei pathogenesis in vivo. BPSS1818 is involved in indirect modulation of mammalian host cell tubulin, probably in concert with other bacterial components [[cite:PUB00159059]].","id":"Pfam:PF07077","interpro_id":"InterPro:IPR009781","name":"Virulence factor BPSS1818","pfam_id":"PF07077","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"BPSS1818","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07077"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF07077.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"b72bdf971de9af65783d279564b28dfb1ca05ebee0c7558fdffe8b6199d1b02a"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Burkholderia pseudomallei (strain 1026b)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/bpss1818-pf07077.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF07077","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/bpss1818-pf07077.yaml"}],"pfam_ids":["PF07077"],"protein_name":"Virulence factor BP1026B_II1948","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MTFYPQVLRNRPRMVIAVAAGVALGLLFPYPLRPFARVLIGWDCTIWLYLVLMWVRMVRAHHHKVREIAMREDENATMVLTIICFATVASIAAIVLELVSAKSVGFRSGLGHYAVTGATMFGAWFLIPTIFTLHYARLYYLSPKEARAMAFPDRELEPDYWDFLYFSFTIAVASQTADVSLRGRSIRRAALAQSILSFYFNMAVLGLSVNVAAGLLS","sequence_length":217,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"4ac53c10ba3b73e93aedc5c2de36d9f41bb30a3b0fb09a33ac84ffe21065b581","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/A0A0H3HW87.json","taxon_id":"884204","uniprot_accession":"A0A0H3HW87","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Burkholderia pseudomallei (strain K96243)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/bpss1818-pf07077.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF07077","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/bpss1818-pf07077.yaml"}],"pfam_ids":["PF07077"],"protein_name":"Virulence factor BPSS1818","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MTFYPQVLRNRPRMVIAVAAGVALGLLFPYPLRPFARVLIGWDCTIWLYLVLMWVRMVRAHHHKVREIAMREDENATMVLTIICFATVASIAAIVLELVSAKSVGFRSGLGHYAVTGATMFGAWFLIPTIFTLHYARLYYLSPKEARAMAFPDRELEPDYWDFLYFSFTIAVASQTADVSLRGRSIRRAALAQSILSFYFNMAVLGLSVNVAAGLLS","sequence_length":217,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"4ac53c10ba3b73e93aedc5c2de36d9f41bb30a3b0fb09a33ac84ffe21065b581","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q63JA0.json","taxon_id":"272560","uniprot_accession":"Q63JA0","uniprot_release":"2026_03"}],"pfam_id":"PF07077","short_name":"BPSS1818","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}