{"cross_mech":[],"family":{"alphafold_models":1843,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"Jagunal is an endoplasmic-reticulum (ER)-membrane protein found in eukaryotes. It is involved in reorganising the ER in cells that must increase exocytic membrane traffic during development, that is, in the oocyte during vitellogenesis. It facilitates vesicular traffic in the subcortex [[cite:PUB00068041]].","domain_architectures":42,"interpro_id":"IPR009787","known_evidence_count":null,"matches":2136,"name":"Jagunal, ER re-organisation during oogenesis","partial_evidence_count":null,"pfam_id":"PF07086","proteins":2114,"proteomes":1537,"short_name":"Jagunal","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07086","structures":1,"taxa":4952,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF07086.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1843,"domain_architectures":42,"matches":2136,"proteins":2114,"proteomes":1537,"structures":1,"taxa":4952},"curation_status":"SEEDED","description":"Jagunal is an endoplasmic-reticulum (ER)-membrane protein found in eukaryotes. It is involved in reorganising the ER in cells that must increase exocytic membrane traffic during development, that is, in the oocyte during vitellogenesis. It facilitates vesicular traffic in the subcortex [[cite:PUB00068041]].","id":"Pfam:PF07086","interpro_id":"InterPro:IPR009787","name":"Jagunal, ER re-organisation during oogenesis","pfam_id":"PF07086","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"Jagunal","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07086"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF07086.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"be5724d8404161e99fbf7bfd2ace9f1d1b06ce3d77e7063af5b91f451ddd9e90"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/jagunal-pf07086.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF07086","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/jagunal-pf07086.yaml"}],"pfam_ids":["PF07086"],"protein_name":"Protein jagunal homolog 1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MASRAGPRAAGTDGSDFQHRERVAMHYQMSVTLKYEIKKLIYVHLVIWLLLVAKMSVGHLRLLSHDQVAMPYQWEYPYLLSIVPSVLGLLSFPRNNISYLVLSMISMGLFSIAPLIYGSMEMFPAAQQLYRHGKAYRFLFGFSAVSVMYLVLVLAVQVHAWQLYYSKKLLDSWFTSTQEKKRK","sequence_length":183,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"919604cb7457710cacde57bb375420fefe5ac6d229f6c2d34ed0f50f8672d1c1","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q5XKN4.json","taxon_id":"10090","uniprot_accession":"Q5XKN4","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Drosophila melanogaster","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/establishment-of-er-localization-go0051686.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0051686","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/establishment-of-er-localization-go0051686.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/vitellogenesis-go0007296.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0007296","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/vitellogenesis-go0007296.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/jagunal-pf07086.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF07086","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/jagunal-pf07086.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:Q7K1V5","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF07086"],"protein_name":"Protein jagunal","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"aa78929e3dc0745b881e6722fcd49c177821366106ffa5461610885a55eaa46f","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MATRGGPMVAGTDGNDFEFRQRVAGTYQISLLNKSRLKYCIFFHALLFFVMLAKLTSDILDHLDIFVLEIEELEVPPPLWWEYVWAASLLTSFLGLSAARGNKVREMQKYMVAILLFAILPLFYCFAYYFSDVWEFATLDKSVELDETDIFVWRGYPYGVFWYAFCFVGFQVHGFTLYFAYNLVKAWKARTATRKFQ","sequence_length":197,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"aa78929e3dc0745b881e6722fcd49c177821366106ffa5461610885a55eaa46f","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q7K1V5.json","taxon_id":"7227","uniprot_accession":"Q7K1V5","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/jagunal-pf07086.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF07086","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/jagunal-pf07086.yaml"}],"pfam_ids":["PF07086"],"protein_name":"Protein jagunal homolog 1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MASRAGPRAAGTDGSDFQHRERVAMHYQMSVTLKYEIKKLIYVHLVIWLLLVAKMSVGHLRLLSHDQVAMPYQWEYPYLLSILPSLLGLLSFPRNNISYLVLSMISMGLFSIAPLIYGSMEMFPAAQQLYRHGKAYRFLFGFSAVSIMYLVLVLAVQVHAWQLYYSKKLLDSWFTSTQEKKHK","sequence_length":183,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"f2f0cc0463ed125a3a01ffdfe8be250ded48af22dbb6c32e6a4586f1619b8de5","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q8N5M9.json","taxon_id":"9606","uniprot_accession":"Q8N5M9","uniprot_release":"2026_03"}],"pfam_id":"PF07086","short_name":"Jagunal","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
