{"cross_mech":[],"family":{"alphafold_models":1336,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This entry includes the transmembrane protein 126 A/B (TMEM126A/B) from animals. Human TMEM126B participates in constructing the membrane arm of mitochondrial respiratory complex I [[cite:PUB00077052]].","domain_architectures":10,"interpro_id":"IPR009801","known_evidence_count":null,"matches":1518,"name":"Transmembrane protein 126","partial_evidence_count":null,"pfam_id":"PF07114","proteins":1508,"proteomes":1022,"short_name":"TMEM126","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07114","structures":0,"taxa":3437,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF07114.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1336,"domain_architectures":10,"matches":1518,"proteins":1508,"proteomes":1022,"structures":0,"taxa":3437},"curation_status":"SEEDED","description":"This entry includes the transmembrane protein 126 A/B (TMEM126A/B) from animals. Human TMEM126B participates in constructing the membrane arm of mitochondrial respiratory complex I [[cite:PUB00077052]].","id":"Pfam:PF07114","interpro_id":"InterPro:IPR009801","name":"Transmembrane protein 126","pfam_id":"PF07114","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"TMEM126","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07114"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF07114.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"460ead06241987d270a5f65a26ed1243f60b54f5a5c2c01dffd3b75c7fdc53c2"}},"protein_examples":{"candidate_count":5,"discovery_scanned":true,"example_count":5,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/tmem126-pf07114.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF07114","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/tmem126-pf07114.yaml"}],"pfam_ids":["PF07114"],"protein_name":"Complex I assembly factor TMEM126B, mitochondrial","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MVVFGYEAGTKPRDSGVVPVGTEEAPKVFKMAASMHGQPSPSLEDAKLRRPMVIEIIEKNFDYLRKEMTQNIYQMATFGTTAGFSGIFSNFLFRRCFKVKHDALKTYASLATLPFLSTVVTDKLFVIDALYSDNISKENCVFRSSLIGIVCGVFYPSSLAFTKNGRLATKYHTVPLPPKGRVLIHWMTLCQTQMKLMAIPLVFQIMFGILNGLYHYAVFEETLEKTIHEE","sequence_length":230,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"16b6e887222cc7fc9fac569c56b449cbba8066218bed4fc91ca5089af3396082","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q8IUX1.json","taxon_id":"9606","uniprot_accession":"Q8IUX1","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/tmem126-pf07114.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF07114","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/tmem126-pf07114.yaml"}],"pfam_ids":["PF07114"],"protein_name":"Complex I assembly factor TMEM126B, mitochondrial","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAASQRPSWSESKVAGVVQEGNREAPQDIKMALYKHGQLIPSLGDAKFRSPIISEIIEKKFEHYRNDKTLNIHGTLVFGTSSSLSGIMANLVFRNSFKVKYEALKTYASLTTLPVLATIVSYKLFVTDALQSGDISKESCVLRSALIGMACGVSYPSALAFYKNGRLAVKYQTVPLPPKGRVMLHWLLLCQTGMKAMAIPLFFQIVMGAFTGLHHYNICEKPRARLVPDD","sequence_length":230,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"482f99a5eac673e0fb21ea3e8b575cded49427d1bf818d6733cfc7c1ea4746ba","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9D1R1.json","taxon_id":"10090","uniprot_accession":"Q9D1R1","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/tmem126-pf07114.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF07114","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/tmem126-pf07114.yaml"}],"pfam_ids":["PF07114"],"protein_name":"Transmembrane protein 126A","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MESHKPSTSKDDLILNIISRKIKQLPESDRNLLEYGSAYIGLNAAFGGLIANSLFRRILNVTQARLASSLPMAVIPFLTANLSYQSLVSLPLSTGDLNCETCTTTRGALVGLVMGGLYPILLAIPVNGGLAARYESSPLPQRGNIFNYWITVSKPVFRKMLFPTLLQTVFASYLGSRQYKLLIKALQLPEPDLEIH","sequence_length":196,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"7d6dd2996db5fc4737e63400b7eedd290498008366b6503de9a4ad32749e3bb1","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9D8Y1.json","taxon_id":"10090","uniprot_accession":"Q9D8Y1","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/tmem126-pf07114.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF07114","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/tmem126-pf07114.yaml"}],"pfam_ids":["PF07114"],"protein_name":"Transmembrane protein 126A","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MENHKSNNKENITIVDISRKINQLPEAERNLLENGSVYVGLNAALCGLIANSLFRRILNVTKARIAAGLPMAGIPFLTTDLTYRCFVSFPLNTGDLDCETCTITRSGLTGLVIGGLYPVFLAIPVNGGLAARYQSALLPHKGNILSYWIRTSKPVFRKMLFPILLQTMFSAYLGSEQYKLLIKALQLSEPGKEIH","sequence_length":195,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"5d21efbbd21daaca80b5aeed2611e2e6001158432acc6a7c78c1c471e1f2b8bf","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9H061.json","taxon_id":"9606","uniprot_accession":"Q9H061","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Drosophila melanogaster","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/tmem126-pf07114.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF07114","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/tmem126-pf07114.yaml"}],"pfam_ids":["PF07114"],"protein_name":"Transmembrane protein 126","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MALSRAKPDELPRDAVVITEDQALKYQWKIITSWDKIGEVWSLRYTPGILSALAAGTGAYINNHYRTKLRLGGHGRLSTYLPIVAVPAIFTMLAHKFFIQRPILLNPLGECPVCIQMRSAAFQTSLGIVYPTILAPFAAFLFATRCYTYRIPSITENPREVFLLWRKFTRPIVPALGTLIGLQALLTMFLTGQEDKQNFKLMLRMREIEHQVEEEHLPQRMDF","sequence_length":223,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"348e261d0e928244343eb91071c92f465eb86fcf296f8991e3baaa5305428ff0","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9VLM7.json","taxon_id":"7227","uniprot_accession":"Q9VLM7","uniprot_release":"2026_03"}],"pfam_id":"PF07114","short_name":"TMEM126","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
