{"cross_mech":[],"family":{"alphafold_models":670,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"ZapC is one of four FtsZ-binding components of the Z ring in bacteria. Formation of the Z ring on the cytoplasmic surface of the membrane is the starting process for assembly of the cell-division apparatus. It binds directly to the Z ring, and although it is not essential for absolute cell division it contributes to it by enhancing the interactions between the FtsZ protofilaments (or polymers) which aggregate to form the ring conformation in the Z ring [[cite:PUB00060666]]. This is the C-terminal domain which contains a pocket with a hydrophobic centre surrounded by conserved basic residues, critical for FtsZ binding [[cite:PUB00101038],[cite:PUB00101039]].","domain_architectures":2,"interpro_id":"IPR048372","known_evidence_count":null,"matches":1065,"name":"Cell-division protein ZapC, C-terminal","partial_evidence_count":null,"pfam_id":"PF07126","proteins":1065,"proteomes":1061,"short_name":"ZapC_C","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07126","structures":2,"taxa":1410,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF07126.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":670,"domain_architectures":2,"matches":1065,"proteins":1065,"proteomes":1061,"structures":2,"taxa":1410},"curation_status":"SEEDED","description":"ZapC is one of four FtsZ-binding components of the Z ring in bacteria. Formation of the Z ring on the cytoplasmic surface of the membrane is the starting process for assembly of the cell-division apparatus. It binds directly to the Z ring, and although it is not essential for absolute cell division it contributes to it by enhancing the interactions between the FtsZ protofilaments (or polymers) which aggregate to form the ring conformation in the Z ring [[cite:PUB00060666]]. This is the C-terminal domain which contains a pocket with a hydrophobic centre surrounded by conserved basic residues, critical for FtsZ binding [[cite:PUB00101038],[cite:PUB00101039]].","id":"Pfam:PF07126","interpro_id":"InterPro:IPR048372","name":"Cell-division protein ZapC, C-terminal","pfam_id":"PF07126","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"ZapC_C","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07126"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF07126.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"9b04482b04c942b9540739bf1fdba98c76b7d562dd0f5a514a8250a767ab1dbf"}},"protein_examples":{"candidate_count":1,"discovery_scanned":true,"example_count":1,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Escherichia coli (strain K12)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/cell-division-protein-zapc-c-terminal-ipr048372.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR048372","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/cell-division-protein-zapc-c-terminal-ipr048372.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/cell-division-protein-zapc-n-terminal-ipr048373.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR048373","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/cell-division-protein-zapc-n-terminal-ipr048373.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/zapc-c-pf07126.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF07126","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/zapc-c-pf07126.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/zapc-n-pf21083.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF21083","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/zapc-n-pf21083.yaml"}],"pfam_ids":["PF07126","PF21083"],"protein_name":"Cell division protein ZapC","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MRIKPDDNWRWYYDEEHDRMMLDLANGMLFRSRFARKMLTPDAFSPAGFCVDDAALYFSFEEKCRDFNLSKEQKAELVLNALVAIRYLKPQMPKSWHFVSHGEMWVPMPGDAACVWLSDTHEQVNLLVVESGENAALCLLAQPCVVIAGRAMQLGDAIKIMNDRLKPQVNVDSFSLEQAV","sequence_length":180,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"5f122f90d57fa44ddca88b85a33a497d961fe2c559c752f455ad1d32320531cb","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/P75862.json","taxon_id":"83333","uniprot_accession":"P75862","uniprot_release":"2026_03"}],"pfam_id":"PF07126","short_name":"ZapC_C","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}