{"cross_mech":[],"family":{"alphafold_models":1669,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family includes spermatogenesis-associated serine-rich protein 2 (SPATS2) and SPATS2-like proteins from mammals. SPATS2 is involved in spermatogenesis and likely to be a cytoplasmic RNA-binding protein [[cite:PUB00101497],[cite:PUB00101498]]. SPATS2 is highly expressed in hepatocellular carcinoma (HCC) and may function as an oncogene. It constitutes a novel diagnostic prognostic marker in liver cancer and a potential therapeutic target for the treatment of HCC [[cite:PUB00101499]].","domain_architectures":10,"interpro_id":"IPR009816","known_evidence_count":null,"matches":2097,"name":"Spermatogenesis-associated serine-rich protein 2-like","partial_evidence_count":null,"pfam_id":"PF07139","proteins":1891,"proteomes":857,"short_name":"SPATS2-like","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07139","structures":0,"taxa":2752,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF07139.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1669,"domain_architectures":10,"matches":2097,"proteins":1891,"proteomes":857,"structures":0,"taxa":2752},"curation_status":"SEEDED","description":"This family includes spermatogenesis-associated serine-rich protein 2 (SPATS2) and SPATS2-like proteins from mammals. SPATS2 is involved in spermatogenesis and likely to be a cytoplasmic RNA-binding protein [[cite:PUB00101497],[cite:PUB00101498]]. SPATS2 is highly expressed in hepatocellular carcinoma (HCC) and may function as an oncogene. It constitutes a novel diagnostic prognostic marker in liver cancer and a potential therapeutic target for the treatment of HCC [[cite:PUB00101499]].","id":"Pfam:PF07139","interpro_id":"InterPro:IPR009816","name":"Spermatogenesis-associated serine-rich protein 2-like","pfam_id":"PF07139","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"SPATS2-like","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07139"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF07139.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"cf570d8b2f072b0175f5ddfa5349c6ed2f98c179f30ce63a5181de4d810c2113"}},"protein_examples":{"candidate_count":4,"discovery_scanned":true,"example_count":4,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/spats2-like-pf07139.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF07139","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/spats2-like-pf07139.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/uba-like-superfamily-ipr009060.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR009060","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/uba-like-superfamily-ipr009060.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:Q86XZ4","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF07139"],"protein_name":"Spermatogenesis-associated serine-rich protein 2","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"46365505a24087a8245db003d91a36795ff7b34618bf9b32fa64c4ac968db105","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MSRKQNQKDSSGFIFDLQSNTVLAQGGAFENMKEKINAVRAIVPNKSNNEIILVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTESVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSKKLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQMSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSLTSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIERGQTHSAGTNGTGVSMEPSPPTPSFKKGLPQRKPRTSQTEAVNS","sequence_length":545,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"46365505a24087a8245db003d91a36795ff7b34618bf9b32fa64c4ac968db105","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q86XZ4.json","taxon_id":"9606","uniprot_accession":"Q86XZ4","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/spats2-like-pf07139.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF07139","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/spats2-like-pf07139.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/uba-like-superfamily-ipr009060.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR009060","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/uba-like-superfamily-ipr009060.yaml"}],"pfam_ids":["PF07139"],"protein_name":"Spermatogenesis-associated serine-rich protein 2","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSRKQSQKDSSGFIFDLQSNTVLAQGGTFENMKEKINAVRAIVPNKSNNEIILVLQHFDNCVDKTVQAFMEGSASEVLKEWIVTGKKKNKKKKSKPKPASEASGSAPDSSKSAPIQEEQPASSEKGSINGYHVNGAINDAESVDSLSEGLETLSIDARELEDPEFAAAETLDRTGSVLENGVSDFEPKSLTAHSISNVQQSRNAAKSLSRTTPGAQVSNLGMENVPLSSTNKKLGSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELQSCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTDVAVRMSEEQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKQSIDSFGQVSHPKNSYSTRSRCSLVAPVSLSGPSDGSAASSSPDASVPSLPGANKRNCAPREASAAMTNSSDRPCQAHREVFPGNRRGGQGYRAQSQKTADPSNPGRHDSVGRYRNSSWYSSGPRYQGVPPQAPGNAGERSRPYSAGTNGTGAISEPSPPKPSFKKGLPQRKPRASQAEAANS","sequence_length":545,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"1571f28c05edd58738e89f9eb5d250dc38119a3d1cc922f3618187dcdd73281c","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q8K1N4.json","taxon_id":"10090","uniprot_accession":"Q8K1N4","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/spats2-like-pf07139.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF07139","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/spats2-like-pf07139.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/uba-like-superfamily-ipr009060.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR009060","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/uba-like-superfamily-ipr009060.yaml"}],"pfam_ids":["PF07139"],"protein_name":"SPATS2-like protein","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAELNTHVNIKEKIYAVRSVVPNKSNNEIVLVLQQFDFNVDKAVQAFVDGSAIQVLKEWNMTGKKKNNKRKRSKSKQHQGNKDAKDKVERPEVGPLQPQAPLVQNGHMNGCEKDSSSPDSTREKLALTPREKKISILEEPPRAQRGVTEGGRLLQQKMSLDGNPRAIHGPSERSDGPQWSAGQPCNPSKPKAKTSPVKSNAPAAHLEIKPDELAKKRGPNIEKSVKDLQRCTVSLTRYRVMIKEEVDSSVKKIKAAFAELHNCIIDKEVSLMAEMDKVKEEAMDILTARQKKAEELKRLTDLASQMAEMQLAELRAEIKHFVSERKYDEELGKAARFSCDIEQLKAQILICGEITHPKNSYSSRTPCSSLLPLLNTHAVASGKQGNFARKSSGHNKPSEGKAANPKMVSGLANTADACHQTMPTNKQQNGPSSQRRRFNPQYHNRLNGPAKSQGGGNEADPMAKSNSRHEHRRQPHNGFRPKNKGGAKNQEAPLGTKAPEAPPHSEKARRRQHAADNLEARPFRGNVSRVSQCNLCPSRIEVSTEATVLSVPAVTLVA","sequence_length":558,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"b380b7d0d183ff99dac64989382dad237466320595de2efa1d24ba29e0c7b398","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q91WJ7.json","taxon_id":"10090","uniprot_accession":"Q91WJ7","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/spats2-like-pf07139.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF07139","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/spats2-like-pf07139.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/uba-like-superfamily-ipr009060.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR009060","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/uba-like-superfamily-ipr009060.yaml"}],"pfam_ids":["PF07139"],"protein_name":"SPATS2-like protein","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAELNTHVNVKEKIYAVRSVVPNKSNNEIVLVLQQFDFNVDKAVQAFVDGSAIQVLKEWNMTGKKKNNKRKRSKSKQHQGNKDAKDKVERPEAGPLQPQPPQIQNGPMNGCEKDSSSTDSANEKPALIPREKKISILEEPSKALRGVTEGNRLLQQKLSLDGNPKPIHGTTERSDGLQWSAEQPCNPSKPKAKTSPVKSNTPAAHLEIKPDELAKKRGPNIEKSVKDLQRCTVSLTRYRVMIKEEVDSSVKKIKAAFAELHNCIIDKEVSLMAEMDKVKEEAMEILTARQKKAEELKRLTDLASQMAEMQLAELRAEIKHFVSERKYDEELGKAARFSCDIEQLKAQIMLCGEITHPKNNYSSRTPCSSLLPLLNAHAATSGKQSNFSRKSSTHNKPSEGKAANPKMVSSLPSTADPSHQTMPANKQNGSSNQRRRFNPQYHNNRLNGPAKSQGSGNEAEPLGKGNSRHEHRRQPHNGFRPKNKGGAKNQEASLGMKTPEAPAHSEKPRRRQHAADTSEARPFRGSVGRVSQCNLCPTRIEVSTDAAVLSVPAVTLVA","sequence_length":558,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"fdacf27e72d70a1909df370fc8e4bd1939c0ae50c180bdee8cdc2fcf3089f0a6","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q9NUQ6.json","taxon_id":"9606","uniprot_accession":"Q9NUQ6","uniprot_release":"2026_03"}],"pfam_id":"PF07139","short_name":"SPATS2-like","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
