{"cross_mech":[],"family":{"alphafold_models":215,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"CdiI immunity proteins function as part of the bacterial contact-dependent growth inhibition (CDI) system. CDI is mediated by the CdiB-CdiA two-partner secretion system. Each CdiA protein exhibits a distinct growth inhibition activity, which resides in the polymorphic C-terminal region (CdiA-CT). Cells with the CDI sytem also express a CdiI immunity protein that blocks the activity of cognate CdiA-CT, thereby protecting the cell from autoinhibition. In many CDI systems the cdiBAI genes are followed by orphan cdiA-CT/cdiI modules, suggesting that these modules are exchanged between the CDI systems of different bacteria [[cite:PUB00074283]].","domain_architectures":1,"interpro_id":"IPR009888","known_evidence_count":null,"matches":357,"name":"CDI immunity protein","partial_evidence_count":null,"pfam_id":"PF07262","proteins":357,"proteomes":236,"short_name":"CdiI","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07262","structures":5,"taxa":552,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF07262.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":215,"domain_architectures":1,"matches":357,"proteins":357,"proteomes":236,"structures":5,"taxa":552},"curation_status":"SEEDED","description":"CdiI immunity proteins function as part of the bacterial contact-dependent growth inhibition (CDI) system. CDI is mediated by the CdiB-CdiA two-partner secretion system. Each CdiA protein exhibits a distinct growth inhibition activity, which resides in the polymorphic C-terminal region (CdiA-CT). Cells with the CDI sytem also express a CdiI immunity protein that blocks the activity of cognate CdiA-CT, thereby protecting the cell from autoinhibition. In many CDI systems the cdiBAI genes are followed by orphan cdiA-CT/cdiI modules, suggesting that these modules are exchanged between the CDI systems of different bacteria [[cite:PUB00074283]].","id":"Pfam:PF07262","interpro_id":"InterPro:IPR009888","name":"CDI immunity protein","pfam_id":"PF07262","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"CdiI","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07262"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF07262.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"d740d5577690f72c0a059a41177bb033154d3e542b2b1609d4a72e6bd702fd16"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Yersinia pseudotuberculosis serotype O:3 (strain YPIII)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/cdii-pf07262.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF07262","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/cdii-pf07262.yaml"}],"pfam_ids":["PF07262"],"protein_name":"Immunity protein CdiI-YPIII","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MNDIVKSAWASVKMNTDFICVDTYSGYRSNQLDPLGVQHLSSPDVSDLDLGEMVKDALSHSRFVLPAPRTDIWIHPEVTFDLDLYDSRRTVERYDEWVKKLMVHYGYKTKRALFKDMKSCDICCNHDAITISPTRHEKLEVWGGTGLKGSDNVILSVDSSPTEIGAGLRLALSRCKG","sequence_length":177,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"ae9e2f764cfa68582c526c50be169a1e0c9f010d134983068532518da8e646d9","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/A0A0R4I987.json","taxon_id":"502800","uniprot_accession":"A0A0R4I987","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Escherichia coli O157:H7 (strain EC869)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/cdii-pf07262.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF07262","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/cdii-pf07262.yaml"}],"pfam_ids":["PF07262"],"protein_name":"Immunity protein CdiI-o11","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAFNKDQDYWANIFVTPDFLSVETYSGLGMTGRDPLFSPRLLQPDVDDKSLGEEILQALSDSRTLDVLEERVAFFDLEKSKEQYAAWIATLMEKYGYRTKRALFKNMKKVGIHLVNDVITIRPSFHEKLEAWSGNRINESDYVVLPADSSPTEIGSGLRLALSRCKG","sequence_length":167,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"dffaee543fe41772c65a941b1e8dd447ad6d3908ca29297871ffe4a97ef541ce","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/B3BM81.json","taxon_id":"478008","uniprot_accession":"B3BM81","uniprot_release":"2026_03"}],"pfam_id":"PF07262","short_name":"CdiI","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
