{"cross_mech":[],"family":{"alphafold_models":1809,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This entry represents the transmembrane protein 43 family of proteins, which may function as tetraspanin-like membrane organisers [[cite:PUB00059300]].","domain_architectures":34,"interpro_id":"IPR012430","known_evidence_count":null,"matches":2260,"name":"Transmembrane protein 43","partial_evidence_count":null,"pfam_id":"PF07787","proteins":2207,"proteomes":1624,"short_name":"TMEM43","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07787","structures":0,"taxa":4657,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF07787.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1809,"domain_architectures":34,"matches":2260,"proteins":2207,"proteomes":1624,"structures":0,"taxa":4657},"curation_status":"SEEDED","description":"This entry represents the transmembrane protein 43 family of proteins, which may function as tetraspanin-like membrane organisers [[cite:PUB00059300]].","id":"Pfam:PF07787","interpro_id":"InterPro:IPR012430","name":"Transmembrane protein 43","pfam_id":"PF07787","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"TMEM43","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07787"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF07787.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"a53ad5300a83b03835ada2b555d47d386e2cd81e0799b42823e9e5ee5b6dc055"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/nuclear-membrane-organization-go0071763.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0071763","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/nuclear-membrane-organization-go0071763.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/tmem43-pf07787.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF07787","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/tmem43-pf07787.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:Q9BTV4","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF07787"],"protein_name":"Transmembrane protein 43","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"57188f2ba974ec689e5fe49477c59255dc058444d840cbfbf1a6c83663e0d1f1","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MAANYSSTSTRREHVKVKTSSQPGFLERLSETSGGMFVGLMAFLLSFYLIFTNEGRALKTATSLAEGLSLVVSPDSIHSVAPENEGRLVHIIGALRTSKLLSDPNYGVHLPAVKLRRHVEMYQWVETEESREYTEDGQVKKETRYSYNTEWRSEIINSKNFDREIGHKNPSAMAVESFMATAPFVQIGRFFLSSGLIDKVDNFKSLSLSKLEDPHVDIIRRGDFFYHSENPKYPEVGDLRVSFSYAGLSGDDPDLGPAHVVTVIARQRGDQLVPFSTKSGDTLLLLHHGDFSAEEVFHRELRSNSMKTWGLRAAGWMAMFMGLNLMTRILYTLVDWFPVFRDLVNIGLKAFAFCVATSLTLLTVAAGWLFYRPLWALLIAGLALVPILVARTRVPAKKLE","sequence_length":400,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"57188f2ba974ec689e5fe49477c59255dc058444d840cbfbf1a6c83663e0d1f1","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9BTV4.json","taxon_id":"9606","uniprot_accession":"Q9BTV4","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/positive-regulation-of-cell-communication-by-electrical-coupling-go0010650.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0010650","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/positive-regulation-of-cell-communication-by-electrical-coupling-go0010650.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/tmem43-pf07787.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF07787","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/tmem43-pf07787.yaml"}],"pfam_ids":["PF07787"],"protein_name":"Transmembrane protein 43","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAANYSSTSSRKEHVKVTSEPQPGFLERLSETSGGMFVGLMTFLLSFYLIFTNEGRALKTATSLAEGLSLVVSPDSIHSVAPENEGRLVHIIGALRTSKLLSDPNYGVHLPAVKLRRHVEMYQWVETEESSEYTEDGQVKKETKYSYNTEWRSEIVNSRNFDREIGHKNPSAMAVESFTATAPFVQIGRFFLSAGLIDKIDNFKALSLAKLEDPHVDIIRRGDFFYHSENPKYPEVGDVRVSFSYAGLSSDDPDLGPAHVVTVIARQRGDQLIPYSTKSGDTLLLLHHGDFSAEEVFRREQKSNSMKTWGLRAAGWMAMFMGLNLMTRILYTLVDWFPVFRDLVNIGLKAFAFCVATSLTLLTVAAGWLFYRPLWAALIGCLALVPIIIARTRVPAKKLE","sequence_length":400,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"6dd347e086bacaaab71164878a19ce11a66fd90f561371990b6d8b1a00ba0b39","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9DBS1.json","taxon_id":"10090","uniprot_accession":"Q9DBS1","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Drosophila melanogaster","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/tmem43-pf07787.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF07787","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/tmem43-pf07787.yaml"}],"pfam_ids":["PF07787"],"protein_name":"Transmembrane protein 43 homolog","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MASLSETLRSHWPIALFGVILFVAGGTELYWNEGRAVHNMMALDEAHADIYSVRFTEEEQEVGLEGRIVHLSGPILVGEPLTEPDYNIQLLAVKLRRRVQMYQWVEEAVEHNYGDSVGTTHSDSRTYYYTREWRDKIVDSRNFYNRHGHTNPSHFPIESHVQVADAVFIGRYELGAEVKEKFNNYQELTSDIRPEDSGVKLHLGIYYHTNDVFNPEVGDLRLLFSFAGMEGEVFSVVGKLSGNKLVPYITSRGVPVLLVYPGGLSVQEVFRLEARAQVLHTWWWRFVGWLLIFFGVTCNTKILRLLFVRVPLLVALAPDPQFPVTGNLLIAFSLALTIAAVAWILHRPVIGACLLLAGASPYVWFTRNLVDYHRLD","sequence_length":376,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"7205bb0713b4c14344f57752cd04871e420c18e8c434793839ea03d86f062668","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9VSB9.json","taxon_id":"7227","uniprot_accession":"Q9VSB9","uniprot_release":"2026_03"}],"pfam_id":"PF07787","short_name":"TMEM43","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
