{"cross_mech":[],"family":{"alphafold_models":2208,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"Members of this family fall in to the drug/metabolite transporter (dmt) superfamily. They carry 10xTM domains arranged as 5+5. Although these two sets may originally have arisen by gene-duplication the divergence now is such that the similarity between the two halves is no longer detectable by sequence.","domain_architectures":70,"interpro_id":"IPR012435","known_evidence_count":null,"matches":2757,"name":"Transmembrane family, TMEM144 of transporters","partial_evidence_count":null,"pfam_id":"PF07857","proteins":2489,"proteomes":1029,"short_name":"TMEM144","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07857","structures":0,"taxa":3231,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF07857.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":2208,"domain_architectures":70,"matches":2757,"proteins":2489,"proteomes":1029,"structures":0,"taxa":3231},"curation_status":"SEEDED","description":"Members of this family fall in to the drug/metabolite transporter (dmt) superfamily. They carry 10xTM domains arranged as 5+5. Although these two sets may originally have arisen by gene-duplication the divergence now is such that the similarity between the two halves is no longer detectable by sequence.","id":"Pfam:PF07857","interpro_id":"InterPro:IPR012435","name":"Transmembrane family, TMEM144 of transporters","pfam_id":"PF07857","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"TMEM144","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07857"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF07857.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"44c5e0b69f8fb78ea172cfbd539baef18ec89c03abfdaedeb0a70600ff724404"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Caenorhabditis elegans","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/tmem144-pf07857.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF07857","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/tmem144-pf07857.yaml"}],"pfam_ids":["PF07857"],"protein_name":"Transmembrane protein 144 homolog","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSIAVGLSACALSSVLFGSMFVPVKKCHSGNGIFVQWIMSTAILLVGIVVYSTQGFPEFEPLAMLGGMFWALGNATAVPIMNTIGIGMGMLVWGTTNCVAGWAAGRFGLFGINSTVPEYPFLNYFGLVLVVFGGFLFSQIRPNEPQTASERSPLMVAPDDDLTDDVAPDDSDIVVPRGGAVPTRAHRNQKRLLAIITSLVAGVFYGFTFVPVIYIQDHPEIYPTAPKTGLGYVFSHYIGIFCTASALMIGYVIYSRNNPFASSRLVGPSMTAGSMWGIAQASWFVANDNLSQAVSFPIISMVPGVIAALWSVFYFRDISGSRNLRLLSIAVAITLIGAICVGVSK","sequence_length":345,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"326b2c398d5f5aa4def7d7ad74bb6a4c6fafd75a7a6194ed5e45055aa8d314e1","sequence_version":3,"source_url":"https://rest.uniprot.org/uniprotkb/Q10000.json","taxon_id":"6239","uniprot_accession":"Q10000","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/tmem144-pf07857.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF07857","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/tmem144-pf07857.yaml"}],"pfam_ids":["PF07857"],"protein_name":"Transmembrane protein 144","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSNNGADLTFGYISCFVAILLFGSNFVPLKKFDTGDGMFLQWVLCAAIWLVALVVNLILHCPKFWPFAMLGGCIWATGNIAVVPIIKTIGLGLGILIWGSFNALTGWASSRFGWFGLDAEEVSNPLLNYIGAGLSVVSAFIFLFIKSEIPNNTCSMDTTPLITEHVINTTQDPCSWVDKLSTVHHRIVGCSLAVISGVLYGSTFVPIIYIKDHSKRNDSIYAGASQYDLDYVFAHFSGIFLTSTVYFLAYCIAMKNSPKLYPEAVLPGFLSGVLWAIATCCWFIANHSLSAVVSFPIITAGPGFIAAMWGIFMFKEIKGLQNYLLMILAFCIILTGALCTAFSKI","sequence_length":345,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"6b6c8756883415488d4fe8201f77b2d76f1a75c5c9dc9c994ff71b8302dee043","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q7Z5S9.json","taxon_id":"9606","uniprot_accession":"Q7Z5S9","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/tmem144-pf07857.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF07857","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/tmem144-pf07857.yaml"}],"pfam_ids":["PF07857"],"protein_name":"Transmembrane protein 144","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSSNATDLTTGYLSSAAAILLFGSNFVPLKKYDTGDGMFLQWVLCAAIWLVALVVNLILHCPKFWPFAMLGGCIWATGNIAVVPIIKTIGLGLGILIWGSFNTLTGWASSRFGWFGMDAEEVSKPMLNYVGAGLSVVSALTFLFIKSEIPNNPGSSDTTPLMTEPVINRTEDRSADSSWVDRLSTTYHRIVGCSLAVISGILYGSTFVPIIYIKDHSRRNDSMYAGASQYDLDYVFAHSSGIFLTSTVYFVAYCVAMKNRPKLYPEAVLPGLLSGVLWAIATCCWFIANHSLSAVISFPIITAGPGLIAALWGILIFKEIQGLRNYLLMMLAFCIILAGALCTAFSKV","sequence_length":348,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"0f4443ca5388a40cc18483dd020fc8501aaf7b781b5d137df57c82e4d4c1a52d","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q8VEH0.json","taxon_id":"10090","uniprot_accession":"Q8VEH0","uniprot_release":"2026_03"}],"pfam_id":"PF07857","short_name":"TMEM144","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
