{"cross_mech":[],"family":{"alphafold_models":6117,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This entry represents the scaffolding anchor of CK1 domain (SACK1 domain) found in the FAM83 family, which includes FAM83A-H. This domain was formerly known as DUF1669 and it has been identified as a CK1 binding domain, which allows the correct subcellular localisation of both FAM83 proteins and the CK1 binding partners and their function [[cite:PUB00155374]]. These proteins are involved in diverse biological processes, depending on their subcellular localisation and binding partners. FAM83A-H interact with the alpha and alpha-like isoforms of CK1, while FAM83A, B, E, and H also interact with the delta and epsilon isoforms of CK1. FAM83 members have function as intermediaries in EGFR/RAS signalling [[cite:PUB00084963]]. FAM83D has been reported to localise to the mitotic spindle and interact with the chromokinesin kinesin family member 22 (KIF22, also called Kid) [[cite:PUB00124155]]. FAM83G, also known as PAWS1 interacts with the transcription factor SMAD1 and promotes the transcription of non-canonical bone morphogenetic protein (BMP) target genes [[cite:PUB00155375]]. FAM83H mutations have been associated with amelogenesis imperfecta [[cite:PUB00092186]].","domain_architectures":43,"interpro_id":"IPR012461","known_evidence_count":null,"matches":7530,"name":"Scaffolding anchor of CK1 domain","partial_evidence_count":null,"pfam_id":"PF07894","proteins":7127,"proteomes":767,"short_name":"SACK1","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF07894","structures":13,"taxa":2356,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF07894.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":6117,"domain_architectures":43,"matches":7530,"proteins":7127,"proteomes":767,"structures":13,"taxa":2356},"curation_status":"SEEDED","description":"This entry represents the scaffolding anchor of CK1 domain (SACK1 domain) found in the FAM83 family, which includes FAM83A-H. This domain was formerly known as DUF1669 and it has been identified as a CK1 binding domain, which allows the correct subcellular localisation of both FAM83 proteins and the CK1 binding partners and their function [[cite:PUB00155374]]. These proteins are involved in diverse biological processes, depending on their subcellular localisation and binding partners. FAM83A-H interact with the alpha and alpha-like isoforms of CK1, while FAM83A, B, E, and H also interact with the delta and epsilon isoforms of CK1. FAM83 members have function as intermediaries in EGFR/RAS signalling [[cite:PUB00084963]]. FAM83D has been reported to localise to the mitotic spindle and interact with the chromokinesin kinesin family member 22 (KIF22, also called Kid) [[cite:PUB00124155]]. FAM83G, also known as PAWS1 interacts with the transcription factor SMAD1 and promotes the transcription of non-canonical bone morphogenetic protein (BMP) target genes [[cite:PUB00155375]]. FAM83H mutations have been associated with amelogenesis imperfecta [[cite:PUB00092186]].","id":"Pfam:PF07894","interpro_id":"InterPro:IPR012461","name":"Scaffolding anchor of CK1 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