{"cross_mech":[],"family":{"alphafold_models":2195,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This entry represents a domain found in a group of bacterial phosphoethanolamine transferases, including eptA from Helicobacter pylori [[cite:PUB00084966]] and eptB from Escherichia coli [ec:2.7.8.42] [[cite:PUB00084967]]. This domain is found immediately N-terminal to the sulphatase domain in many sulphatases.","domain_architectures":8,"interpro_id":"IPR012549","known_evidence_count":null,"matches":3702,"name":"Phosphoethanolamine transferase EptA/EptB","partial_evidence_count":null,"pfam_id":"PF08019","proteins":3699,"proteomes":2709,"short_name":"EptA_B_N","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08019","structures":2,"taxa":3951,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF08019.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":2195,"domain_architectures":8,"matches":3702,"proteins":3699,"proteomes":2709,"structures":2,"taxa":3951},"curation_status":"SEEDED","description":"This entry represents a domain found in a group of bacterial phosphoethanolamine transferases, including eptA from Helicobacter pylori [[cite:PUB00084966]] and eptB from Escherichia coli [ec:2.7.8.42] [[cite:PUB00084967]]. This domain is found immediately N-terminal to the sulphatase domain in many sulphatases.","id":"Pfam:PF08019","interpro_id":"InterPro:IPR012549","name":"Phosphoethanolamine transferase EptA/EptB","pfam_id":"PF08019","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"EptA_B_N","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08019"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF08019.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"af2906ab90b690b1098288e72b5756c6add72499e0b2efaf4585f3db8c978e0e"}},"protein_examples":{"candidate_count":4,"discovery_scanned":true,"example_count":4,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Escherichia coli","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/epta-b-n-pf08019.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF08019","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/epta-b-n-pf08019.yaml"}],"pfam_ids":["PF00884","PF08019"],"protein_name":"Phosphatidylethanolamine transferase Mcr-1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MMQHTSVWYRRSVSPFVLVASVAVFLTATANLTFFDKISQTYPIADNLGFVLTIAVVLFGAMLLITTLLSSYRYVLKPVLILLLIMGAVTSYFTDTYGTVYDTTMLQNALQTDQAETKDLLNAAFIMRIIGLGVLPSLLVAFVKVDYPTWGKGLMRRLGLIVASLALILLPVVAFSSHYASFFRVHKPLRSYVNPIMPIYSVGKLASIEYKKASAPKDTIYHAKDAVQATKPDMRKPRLVVFVVGETARADHVSFNGYERDTFPQLAKIDGVTNFSNVTSCGTSTAYSVPCMFSYLGADEYDVDTAKYQENVLDTLDRLGVSILWRDNNSDSKGVMDKLPKAQFADYKSATNNAICNTNPYNECRDVGMLVGLDDFVAANNGKDMLIMLHQMGNHGPAYFKRYDEKFAKFTPVCEGNELAKCEHQSLINAYDNALLATDDFIAQSIQWLQTHSNAYDVSMLYVSDHGESLGENGVYLHGMPNAFAPKEQRSVPAFFWTDKQTGITPMATDTVLTHDAITPTLLKLFDVTADKVKDRTAFIR","sequence_length":541,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"a238c6956a74d131d6066a260a5c009d879bf6361e40b75309e374881373db29","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/A0A0R6L508.json","taxon_id":"562","uniprot_accession":"A0A0R6L508","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Escherichia coli","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/epta-b-n-pf08019.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF08019","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/epta-b-n-pf08019.yaml"}],"pfam_ids":["PF00884","PF08019"],"protein_name":"Phosphatidylethanolamine transferase Mcr-2","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MTSHHSWYRYSINPFVLMGLVALFLAATANLTFFEKAMAVYPVSDNLGFIISMAVAVMGAMLLIVVLLSYRYVLKPVLILLLIMGAVTSYFTDTYGTVYDTTMLQNAMQTDQAESKDLMNLAFFVRIIGLGVLPSVLVAVAKVNYPTWGKGLIQRAMTWGVSLVLLLVPIGLFSSQYASFFRVHKPVRFYINPITPIYSVGKLASIEYKKATAPTDTIYHAKDAVQTTKPSERKPRLVVFVVGETARADHVQFNGYGRETFPQLAKVDGLANFSQVTSCGTSTAYSVPCMFSYLGQDDYDVDTAKYQENVLDTLDRLGVGILWRDNNSDSKGVMDKLPATQYFDYKSATNNTICNTNPYNECRDVGMLVGLDDYVSANNGKDMLIMLHQMGNHGPAYFKRYDEQFAKFTPVCEGNELAKCEHQSLINAYDNALLATDDFIAKSIDWLKTHEANYDVAMLYVSDHGESLGENGVYLHGMPNAFAPKEQRAVPAFFWSNNTTFKPTASDTVLTHDAITPTLLKLFDVTAGKVKDRAAFIQ","sequence_length":538,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"ac11cd8f4c43b75871bc89c0dbaa1f186110d0c878b6152a899c2abf8270e1ac","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/A0A1C3NEV1.json","taxon_id":"562","uniprot_accession":"A0A1C3NEV1","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Escherichia coli (strain K12)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/protein_family/ncbifam/phosphoethanolamine-transferase-epta-nf008619.yaml","qualification_status":"NOT_ASSESSED","record_id":"NCBIfam:NF008619","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/protein_family/ncbifam/phosphoethanolamine-transferase-epta-nf008619.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/cdd/lipooligosaccharide-phosphoethanolamine-transferase-a-lpta-or-lipid-a--cd16017.yaml","qualification_status":"NOT_ASSESSED","record_id":"CDD:cd16017","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/cdd/lipooligosaccharide-phosphoethanolamine-transferase-a-lpta-or-lipid-a--cd16017.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/phosphoethanolamine-transferase-c-terminal-domain-ipr058130.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR058130","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/phosphoethanolamine-transferase-c-terminal-domain-ipr058130.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/phosphoethanolamine-transferase-n-terminal-ipr012549.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR012549","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/phosphoethanolamine-transferase-n-terminal-ipr012549.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/ncbifam/phosphoethanolamine-lipid-a-transferase-nf028537.yaml","qualification_status":"NOT_ASSESSED","record_id":"NCBIfam:NF028537","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/ncbifam/phosphoethanolamine-lipid-a-transferase-nf028537.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/epta-b-n-pf08019.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF08019","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/epta-b-n-pf08019.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:P30845","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF00884","PF08019"],"protein_name":"Phosphoethanolamine transferase EptA","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"4b3468a7badf0892124bb9892d47c51ab995b9a4bdc0b38e35b6c12428837297","sequence_version":2,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MLKRLLKRPSLNLLAWLLLAAFYISICLNIAFFKQVLQALPLDSLHNVLVFLSMPVVAFSVINIVLTLSSFLWLNRPLACLFILVGAAAQYFIMTYGIVIDRSMIANIIDTTPAESYALMTPQMLLTLGFSGVLAALIACWIKIKPATSRLRSVLFRGANILVSVLLILLVAALFYKDYASLFRNNKELVKSLSPSNSIVASWSWYSHQRLANLPLVRIGEDAHRNPLMQNEKRKNLTILIVGETSRAENFSLNGYPRETNPRLAKDNVVYFPNTASCGTATAVSVPCMFSDMPREHYKEELAQHQEGVLDIIQRAGINVLWNDNDGGCKGACDRVPHQNVTALNLPDQCINGECYDEVLFHGLEEYINNLQGDGVIVLHTIGSHGPTYYNRYPPQFRKFTPTCDTNEIQTCTKEQLVNTYDNTLVYVDYIVDKAINLLKEHQDKFTTSLVYLSDHGESLGENGIYLHGLPYAIAPDSQKQVPMLLWLSEDYQKRYQVDQNCLQKQAQTQHYSQDNLFSTLLGLTGVETKYYQAADDILQTCRRVSE","sequence_length":547,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"4b3468a7badf0892124bb9892d47c51ab995b9a4bdc0b38e35b6c12428837297","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/P30845.json","taxon_id":"83333","uniprot_accession":"P30845","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Escherichia coli (strain K12)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/phosphatidylethanolamine-kdo2-lipid-a-phosphoethanolamine-transferase-activity-go0043838.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0043838","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/phosphatidylethanolamine-kdo2-lipid-a-phosphoethanolamine-transferase-activity-go0043838.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/protein_family/ncbifam/kdo-2-lipid-a-phosphoethanolamine-7-transferase-nf008593.yaml","qualification_status":"NOT_ASSESSED","record_id":"NCBIfam:NF008593","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/protein_family/ncbifam/kdo-2-lipid-a-phosphoethanolamine-7-transferase-nf008593.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/cdd/lipooligosaccharide-phosphoethanolamine-transferase-a-lpta-or-lipid-a--cd16017.yaml","qualification_status":"NOT_ASSESSED","record_id":"CDD:cd16017","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/cdd/lipooligosaccharide-phosphoethanolamine-transferase-a-lpta-or-lipid-a--cd16017.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/phosphoethanolamine-transferase-c-terminal-domain-ipr058130.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR058130","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/phosphoethanolamine-transferase-c-terminal-domain-ipr058130.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/phosphoethanolamine-transferase-n-terminal-ipr012549.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR012549","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/phosphoethanolamine-transferase-n-terminal-ipr012549.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:P37661","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF00884","PF08019"],"protein_name":"Kdo(2)-lipid A phosphoethanolamine 7''-transferase","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"723016d483bb2057f07d1bcbd2fa5c71e3080fd849e194d8178689125c00f64c","sequence_version":3,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MRYIKSITQQKLSFLLAIYIGLFMNGAVFYRRFGSYAHDFTVWKGISAVVELAATVLVTFFLLRLLSLFGRRSWRILASLVVLFSAGASYYMTFLNVVIGYGIIASVMTTDIDLSKEVVGLNFILWLIAVSALPLILIWNNRCRYTLLRQLRTPGQRIRSLAVVVLAGIMVWAPIRLLDIQQKKVERATGVDLPSYGGVVANSYLPSNWLSALGLYAWARVDESSDNNSLLNPAKKFTYQAPQNVDDTYVVFIIGETTRWDHMGIFGYERNTTPKLAQEKNLAAFRGYSCDTATKLSLRCMFVRQGGAEDNPQRTLKEQNIFAVLKQLGFSSDLYAMQSEMWFYSNTMADNIAYREQIGAEPRNRGKPVDDMLLVDEMQQSLGRNPDGKHLIILHTKGSHFNYTQRYPRSFAQWKPECIGVDSGCTKAQMINSYDNSVTYVDHFISSVIDQVRDKKAIVFYAADHGESINEREHLHGTPRELAPPEQFRVPMMVWMSDKYLENPANAQAFAQLKKEADMKVPRRHVELYDTIMGCLGYTSPDGGINENNNWCHIPQAKEAAAN","sequence_length":563,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"723016d483bb2057f07d1bcbd2fa5c71e3080fd849e194d8178689125c00f64c","sequence_version":3,"source_url":"https://rest.uniprot.org/uniprotkb/P37661.json","taxon_id":"83333","uniprot_accession":"P37661","uniprot_release":"2026_03"}],"pfam_id":"PF08019","short_name":"EptA_B_N","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}