{"cross_mech":[],"family":{"alphafold_models":1224,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This entry represents a histone acetyltransferase catalytic domain found in fungal proteins, including RTT109 (also known as KAT11) from budding and fission yeasts and Candida species. This domain catalyses the acetylation of lysine residues on histone H3, including H3K56, H3K9, H3K14, H3K23 and H3K27 [[cite:PUB00045009],[cite:PUB00042670]]. The domain functions within a complex with histone chaperones such as VPS75 that regulate substrate specificity [[cite:PUB00051225]]. Acetylation of H3K56 by this domain promotes nucleosome assembly, DNA repair and transcriptional regulation during S-phase [[cite:PUB00045009],[cite:PUB00042670]]. The domain is also found in other histone acetyltransferases including p300/CBP which share a similar fold but differ in catalytic properties and cofactor requirements [[cite:PUB00051225]]. Members of this family show conservation across most eukaryotic fungi.","domain_architectures":30,"interpro_id":"IPR016849","known_evidence_count":null,"matches":2178,"name":"Histone acetyltransferase KAT11-type domain","partial_evidence_count":null,"pfam_id":"PF08214","proteins":1484,"proteomes":1444,"short_name":"HAT_KAT11","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08214","structures":19,"taxa":3025,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF08214.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1224,"domain_architectures":30,"matches":2178,"proteins":1484,"proteomes":1444,"structures":19,"taxa":3025},"curation_status":"SEEDED","description":"This entry represents a histone acetyltransferase catalytic domain found in fungal proteins, including RTT109 (also known as KAT11) from budding and fission yeasts and Candida species. This domain catalyses the acetylation of lysine residues on histone H3, including H3K56, H3K9, H3K14, H3K23 and H3K27 [[cite:PUB00045009],[cite:PUB00042670]]. The domain functions within a complex with histone chaperones such as VPS75 that regulate substrate specificity [[cite:PUB00051225]]. Acetylation of H3K56 by this domain promotes nucleosome assembly, DNA repair and transcriptional regulation during S-phase [[cite:PUB00045009],[cite:PUB00042670]]. The domain is also found in other histone acetyltransferases including p300/CBP which share a similar fold but differ in catalytic properties and cofactor requirements [[cite:PUB00051225]]. Members of this family show conservation across most eukaryotic fungi.","id":"Pfam:PF08214","interpro_id":"InterPro:IPR016849","name":"Histone acetyltransferase KAT11-type domain","pfam_id":"PF08214","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"HAT_KAT11","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08214"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF08214.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"eac822dfd3f4eb12a19dd1c6b6e688a03efcc24301f43c09d016aad4947e8524"}},"protein_examples":{"candidate_count":4,"discovery_scanned":true,"example_count":1,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/localization/go/h3-histone-acetyltransferase-complex-go0070775.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0070775","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/localization/go/h3-histone-acetyltransferase-complex-go0070775.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/histone-h3-acetyltransferase-activity-go0010484.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0010484","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/histone-h3-acetyltransferase-activity-go0010484.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/histone-h3k14-acetyltransferase-activity-go0036408.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0036408","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/histone-h3k14-acetyltransferase-activity-go0036408.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/histone-h3k23-acetyltransferase-activity-go0043994.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0043994","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/histone-h3k23-acetyltransferase-activity-go0043994.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/histone-h3k27-acetyltransferase-activity-go0044017.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0044017","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/histone-h3k27-acetyltransferase-activity-go0044017.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/histone-h3k56-acetyltransferase-activity-go0032931.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0032931","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/histone-h3k56-acetyltransferase-activity-go0032931.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/histone-h3k9-acetyltransferase-activity-go0043992.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0043992","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/histone-h3k9-acetyltransferase-activity-go0043992.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/protein-lysine-acetyltransferase-activity-go0061733.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0061733","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/protein-lysine-acetyltransferase-activity-go0061733.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/cellular-response-to-stress-go0033554.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0033554","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/cellular-response-to-stress-go0033554.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/dna-replication-dependent-chromatin-assembly-go0006335.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0006335","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/dna-replication-dependent-chromatin-assembly-go0006335.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/maintenance-of-rdna-go0043007.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0043007","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/maintenance-of-rdna-go0043007.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/regulation-of-double-strand-break-repair-via-nonhomologous-end-joining-go2001032.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:2001032","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/regulation-of-double-strand-break-repair-via-nonhomologous-end-joining-go2001032.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/replication-born-double-strand-break-repair-via-sister-chromatid-exchange-go1990414.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:1990414","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/replication-born-double-strand-break-repair-via-sister-chromatid-exchange-go1990414.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/transposable-element-silencing-go0010526.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0010526","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/transposable-element-silencing-go0010526.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/hat-kat11-pf08214.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF08214","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/hat-kat11-pf08214.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/profile/rtt109-hat.yaml","qualification_status":"NOT_ASSESSED","record_id":"PROSITE:PS51728","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/profile/rtt109-hat.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:Q07794","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF08214"],"protein_name":"Histone acetyltransferase RTT109","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"94c8ad01629519c8c82979ffe5516efb8d575ae2dc4ec2d95a007be1cdbea2e5","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MSLNDFLSSVLPVSEQFEYLSLQSIPLETHAVVTPNKDDKRVPKSTIKTQHFFSLFHQGKVFFSLEVYVYVTLWDEADAERLIFVSKADTNGYCNTRVSVRDITKIILEFILSIDPNYYLQKVKPAIRSYKKISPELISAASTPARTLRILARRLKQSGSTVLKEIESPRFQQDLYLSFTCPREILTKICLFTRPASQYLFPDSSKNSKKHILNGEELMKWWGFILDRLLIECFQNDTQAKLRIPGEDPARVRSYLRGMKYPLWQVGDIFTSKENSLAVYNIPLFPDDPKARFIHQLAEEDRLLKVSLSSFWIELQERQEFKLSVTSSVMGISGYSLATPSLFPSSADVIVPKSRKQFRAIKKYITGEEYDTEEGAIEAFTNIRDFLLLRMATNLQSLTGKREHRERNQPVPASNINTLAITMLKPRKKAKALPKT","sequence_length":436,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"94c8ad01629519c8c82979ffe5516efb8d575ae2dc4ec2d95a007be1cdbea2e5","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q07794.json","taxon_id":"559292","uniprot_accession":"Q07794","uniprot_release":"2026_03"}],"pfam_id":"PF08214","short_name":"HAT_KAT11","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[{"origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/creb-binding-pf09030.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF09030","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/creb-binding-pf09030.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/kix-pf02172.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF02172","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/kix-pf02172.yaml"}],"reason":"PFAM_NOT_IN_CURRENT_ENTRY","uniprot_accession":"B2RWS6"},{"origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/creb-binding-pf09030.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF09030","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/creb-binding-pf09030.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/hat-kat11-pf08214.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF08214","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/hat-kat11-pf08214.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/kix-pf02172.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF02172","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/kix-pf02172.yaml"}],"reason":"PFAM_NOT_IN_CURRENT_ENTRY","uniprot_accession":"Q09472"},{"origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/creb-binding-pf09030.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF09030","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/creb-binding-pf09030.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/hat-kat11-pf08214.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF08214","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/hat-kat11-pf08214.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/kix-pf02172.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF02172","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/kix-pf02172.yaml"}],"reason":"PFAM_NOT_IN_CURRENT_ENTRY","uniprot_accession":"Q92793"}]}}