{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF08409","protein_label":"Protein O-mannosyl-transferase TMTC3","reviewed":true,"short_name":"TMTC_DUF1736","source_category":"function/molecular_function/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/molecular_function/go/dolichyl-phosphate-mannose-protein-mannosyltransferase-activity-go0004169.yaml","source_record_id":"GO:0004169","source_record_label":"dolichyl-phosphate-mannose-protein mannosyltransferase activity","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"Q8BRH0","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF08409","protein_label":"Protein O-mannosyl-transferase TMTC3","reviewed":true,"short_name":"TMTC_DUF1736","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/bud-outgrowth-involved-in-lung-branching-go0060447.yaml","source_record_id":"GO:0060447","source_record_label":"bud outgrowth involved in lung branching","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"Q8BRH0","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF08409","protein_label":"Protein O-mannosyl-transferase TMTC4","reviewed":true,"short_name":"TMTC_DUF1736","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/outer-hair-cell-apoptotic-process-go1905584.yaml","source_record_id":"GO:1905584","source_record_label":"outer hair cell apoptotic process","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"Q8BG19","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF08409","protein_label":"Protein O-mannosyl-transferase TMTC4","reviewed":true,"short_name":"TMTC_DUF1736","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/positive-regulation-of-endoplasmic-reticulum-calcium-ion-concentration-go0032470.yaml","source_record_id":"GO:0032470","source_record_label":"positive regulation of endoplasmic reticulum calcium ion concentration","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"Q8BG19","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF08409","protein_label":"Protein O-mannosyl-transferase Tmtc3","reviewed":true,"short_name":"TMTC_DUF1736","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/regulation-of-macromolecule-metabolic-process-go0060255.yaml","source_record_id":"GO:0060255","source_record_label":"regulation of macromolecule metabolic process","source_section":"canonical_examples","taxon_id":"NCBITaxon:7227","taxon_label":"Drosophila melanogaster","uniprot_accession":"Q7K4B6","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF08409","protein_label":"Protein O-mannosyl-transferase F38B6.6","reviewed":true,"short_name":"TMTC_DUF1736","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/protein-o-mannosyl-transferase-tmtc-duf1736-ipr013618.yaml","source_record_id":"InterPro:IPR013618","source_record_label":"Protein O-mannosyl-transferase TMTC, DUF1736","source_section":"canonical_examples","taxon_id":"NCBITaxon:6239","taxon_label":"Caenorhabditis elegans","uniprot_accession":"Q20144","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF08409","protein_label":"Protein O-mannosyl-transferase TMTC2","reviewed":true,"short_name":"TMTC_DUF1736","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/protein-o-mannosyl-transferase-tmtc-duf1736-ipr013618.yaml","source_record_id":"InterPro:IPR013618","source_record_label":"Protein O-mannosyl-transferase TMTC, DUF1736","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"Q56A06","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF08409","protein_label":"Protein O-mannosyl-transferase TMTC4","reviewed":true,"short_name":"TMTC_DUF1736","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/protein-o-mannosyl-transferase-tmtc-duf1736-ipr013618.yaml","source_record_id":"InterPro:IPR013618","source_record_label":"Protein O-mannosyl-transferase TMTC, DUF1736","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q5T4D3","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF08409","protein_label":"Protein O-mannosyl-transferase TMTC3","reviewed":true,"short_name":"TMTC_DUF1736","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/protein-o-mannosyl-transferase-tmtc-duf1736-ipr013618.yaml","source_record_id":"InterPro:IPR013618","source_record_label":"Protein O-mannosyl-transferase TMTC, DUF1736","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q6ZXV5","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF08409","protein_label":"Protein O-mannosyl-transferase TMTC4","reviewed":true,"short_name":"TMTC_DUF1736","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/protein-o-mannosyl-transferase-tmtc-duf1736-ipr013618.yaml","source_record_id":"InterPro:IPR013618","source_record_label":"Protein O-mannosyl-transferase TMTC, DUF1736","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"Q8BG19","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF08409","protein_label":"Protein O-mannosyl-transferase TMTC3","reviewed":true,"short_name":"TMTC_DUF1736","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/protein-o-mannosyl-transferase-tmtc-duf1736-ipr013618.yaml","source_record_id":"InterPro:IPR013618","source_record_label":"Protein O-mannosyl-transferase TMTC, DUF1736","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"Q8BRH0","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF08409","protein_label":"Protein O-mannosyl-transferase TMTC2","reviewed":true,"short_name":"TMTC_DUF1736","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/protein-o-mannosyl-transferase-tmtc-duf1736-ipr013618.yaml","source_record_id":"InterPro:IPR013618","source_record_label":"Protein O-mannosyl-transferase TMTC, DUF1736","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q8N394","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF08409","protein_label":"Protein O-mannosyl-transferase Tmtc4","reviewed":true,"short_name":"TMTC_DUF1736","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/protein-o-mannosyl-transferase-tmtc-duf1736-ipr013618.yaml","source_record_id":"InterPro:IPR013618","source_record_label":"Protein O-mannosyl-transferase TMTC, DUF1736","source_section":"canonical_examples","taxon_id":"NCBITaxon:7227","taxon_label":"Drosophila melanogaster","uniprot_accession":"Q9VF81","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF08409","protein_label":"","reviewed":null,"short_name":"TMTC_DUF1736","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/protein-o-mannosyl-transferase-tmtc-duf1736-ipr013618.yaml","source_record_id":"InterPro:IPR013618","source_record_label":"Protein O-mannosyl-transferase TMTC, DUF1736","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF08409","protein_label":"Protein O-mannosyl-transferase F38B6.6","reviewed":true,"short_name":"TMTC_DUF1736","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/tmtc-duf1736-pf08409.yaml","source_record_id":"Pfam:PF08409","source_record_label":"Protein O-mannosyl-transferase TMTC, DUF1736","source_section":"canonical_examples","taxon_id":"NCBITaxon:6239","taxon_label":"Caenorhabditis elegans","uniprot_accession":"Q20144","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF08409","protein_label":"Protein O-mannosyl-transferase TMTC2","reviewed":true,"short_name":"TMTC_DUF1736","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/tmtc-duf1736-pf08409.yaml","source_record_id":"Pfam:PF08409","source_record_label":"Protein O-mannosyl-transferase TMTC, DUF1736","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"Q56A06","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF08409","protein_label":"Protein O-mannosyl-transferase TMTC4","reviewed":true,"short_name":"TMTC_DUF1736","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/tmtc-duf1736-pf08409.yaml","source_record_id":"Pfam:PF08409","source_record_label":"Protein O-mannosyl-transferase TMTC, DUF1736","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q5T4D3","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF08409","protein_label":"Protein O-mannosyl-transferase TMTC3","reviewed":true,"short_name":"TMTC_DUF1736","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/tmtc-duf1736-pf08409.yaml","source_record_id":"Pfam:PF08409","source_record_label":"Protein O-mannosyl-transferase TMTC, DUF1736","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q6ZXV5","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF08409","protein_label":"Protein O-mannosyl-transferase TMTC4","reviewed":true,"short_name":"TMTC_DUF1736","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/tmtc-duf1736-pf08409.yaml","source_record_id":"Pfam:PF08409","source_record_label":"Protein O-mannosyl-transferase TMTC, DUF1736","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"Q8BG19","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF08409","protein_label":"Protein O-mannosyl-transferase TMTC3","reviewed":true,"short_name":"TMTC_DUF1736","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/tmtc-duf1736-pf08409.yaml","source_record_id":"Pfam:PF08409","source_record_label":"Protein O-mannosyl-transferase TMTC, DUF1736","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"Q8BRH0","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF08409","protein_label":"Protein O-mannosyl-transferase TMTC2","reviewed":true,"short_name":"TMTC_DUF1736","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/tmtc-duf1736-pf08409.yaml","source_record_id":"Pfam:PF08409","source_record_label":"Protein O-mannosyl-transferase TMTC, DUF1736","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q8N394","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF08409","protein_label":"Protein O-mannosyl-transferase Tmtc4","reviewed":true,"short_name":"TMTC_DUF1736","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/tmtc-duf1736-pf08409.yaml","source_record_id":"Pfam:PF08409","source_record_label":"Protein O-mannosyl-transferase TMTC, DUF1736","source_section":"canonical_examples","taxon_id":"NCBITaxon:7227","taxon_label":"Drosophila melanogaster","uniprot_accession":"Q9VF81","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF08409","protein_label":"","reviewed":null,"short_name":"TMTC_DUF1736","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/tmtc-duf1736-pf08409.yaml","source_record_id":"Pfam:PF08409","source_record_label":"Protein O-mannosyl-transferase TMTC, DUF1736","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF08409","protein_label":"Protein O-mannosyl-transferase TMTC4","reviewed":true,"short_name":"TMTC_DUF1736","source_category":"sequence/repeat/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/repeat/pfam/tpr-17-pf13431.yaml","source_record_id":"Pfam:PF13431","source_record_label":"Tetratricopeptide repeat","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q5T4D3","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF08409","protein_label":"Protein O-mannosyl-transferase TMTC3","reviewed":true,"short_name":"TMTC_DUF1736","source_category":"sequence/repeat/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/repeat/pfam/tpr-17-pf13431.yaml","source_record_id":"Pfam:PF13431","source_record_label":"Tetratricopeptide repeat","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q6ZXV5","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF08409","protein_label":"Protein O-mannosyl-transferase TMTC4","reviewed":true,"short_name":"TMTC_DUF1736","source_category":"sequence/repeat/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/repeat/pfam/tpr-17-pf13431.yaml","source_record_id":"Pfam:PF13431","source_record_label":"Tetratricopeptide repeat","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"Q8BG19","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF08409","protein_label":"Protein O-mannosyl-transferase TMTC3","reviewed":true,"short_name":"TMTC_DUF1736","source_category":"sequence/repeat/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/repeat/pfam/tpr-6-pf13174.yaml","source_record_id":"Pfam:PF13174","source_record_label":"Tetratricopeptide repeat","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q6ZXV5","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":6079,"candidate_reasons":["name_matches_duf","description_says_unknown_function","domain_of_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":9,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":9},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This domain of unknown function is found in O-mannosyl -transferases TMTC1-4, and constitutes a loop between TM7 and TM8 located in the ER lumen that contains a small hydrophobic, but not membrane-embedded helix. This loop is critical for catalysis and binding of ligands, especially the lipid-linked sugar moiety [[cite:PUB00098068]]. TMTCs transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases acting primarily on the cadherin superfamily; each member has distinct roles in decorating the cadherin domains with O-linked mannose glycans at specific regions. These proteins also act as O-mannosyl-transferase on other proteins such as PDIA3 [[cite:PUB00098069]].","domain_architectures":1307,"interpro_id":"IPR013618","known_evidence_count":null,"matches":6939,"name":"Protein O-mannosyl-transferase TMTC, DUF1736","partial_evidence_count":null,"pfam_id":"PF08409","proteins":6936,"proteomes":1367,"short_name":"TMTC_DUF1736","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08409","structures":0,"taxa":4389,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF08409.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":6079,"domain_architectures":1307,"matches":6939,"proteins":6936,"proteomes":1367,"structures":0,"taxa":4389},"curation_status":"SEEDED","description":"This domain of unknown function is found in O-mannosyl -transferases TMTC1-4, and constitutes a loop between TM7 and TM8 located in the ER lumen that contains a small hydrophobic, but not membrane-embedded helix. This loop is critical for catalysis and binding of ligands, especially the lipid-linked sugar moiety [[cite:PUB00098068]]. TMTCs transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases acting primarily on the cadherin superfamily; each member has distinct roles in decorating the cadherin domains with O-linked mannose glycans at specific regions. These proteins also act as O-mannosyl-transferase on other proteins such as PDIA3 [[cite:PUB00098069]].","id":"Pfam:PF08409","interpro_id":"InterPro:IPR013618","name":"Protein O-mannosyl-transferase TMTC, DUF1736","pfam_id":"PF08409","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"TMTC_DUF1736","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08409"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF08409.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"d27360618eca47dc132a16d17f628811b4113b5a302adf1039ea50eb2bda994d"}},"protein_examples":{"candidate_count":9,"discovery_scanned":true,"example_count":9,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Caenorhabditis elegans","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/protein-o-mannosyl-transferase-tmtc-duf1736-ipr013618.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR013618","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/protein-o-mannosyl-transferase-tmtc-duf1736-ipr013618.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/tmtc-duf1736-pf08409.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF08409","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/tmtc-duf1736-pf08409.yaml"}],"pfam_ids":["PF08409","PF13181","PF13431"],"protein_name":"Protein O-mannosyl-transferase F38B6.6","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MKKHLHHKVSGSCDPGDRSPKEKGRSQGIRNLLILISLSIIPYLSCLGGDFVFDDAESIVNNPIVNGKDPLLQIFSRDFWGRSISSSNSHKSYRPVTTFTFWLNYKLHETSTLGYHVVNIICHTVATLVFYKLGKQLEHIFDFFNIAFSASILFAVHPVHTEAVANITGRAELLMTIFSLAALILHVKNREINCKFVLLVILSTLSKEQGLMTIPIAICIDFLAHRSCRSNFVRMICLLVAIGFLRMMVNGFEAAKFTKLDNPTAFLNSKFYRMINYTYIWLYHAYLLVIPVNLCFDYSMGCISSITTMWDLRALSPVLIFTIVIIGVKFQNECRAFTLSSLMGIISFLPASNIFFTVGFSIAERVLYLPSAGFCLLCAIIFKKLSVHFKNADVLSITLILLLISKTYRRSGEWKTELSLYSSGLSVCPTNAKIHYNLGKVLGDNGLTKDAEKNYWNAIKLDPSYEQALNNLGNLLEKSGDSKTAESLLARAVTLRPSFAVAWMNLGISQMNLKKYYEAEKSLKNSLLIRPNSAHCLFNLGVLYQRTNRDEMAMSAWKNATRIDPSHSQSWTNLFVVLDHLSQCSQVIDLSYQALSSVPNESRVHMQIGSCHAKHSNFTAAENHIKSAIDLNPTSVLFHANLGILYQRMSRHKEAESQYRIVLALDSKNIVAKQNLQKLEEHNCYNSTLP","sequence_length":690,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"fea1f95d989ba0920eee9f0fa819e9204a1b72cc1812ed7ddcd1a9a56f0959dd","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q20144.json","taxon_id":"6239","uniprot_accession":"Q20144","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/protein-o-mannosyl-transferase-tmtc-duf1736-ipr013618.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR013618","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/protein-o-mannosyl-transferase-tmtc-duf1736-ipr013618.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/tmtc-duf1736-pf08409.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF08409","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/tmtc-duf1736-pf08409.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:Q56A06","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF00515","PF08409","PF13181","PF13424","PF13432"],"protein_name":"Protein O-mannosyl-transferase TMTC2","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"3e993e633259dc16812e928bec21fa543886d09829bf4f457e4accda14d69723","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MIAELVSSALGLALYLNTLSADFCYDDSRAIKTNQDLLPETPWTHIFYNDFWGTLLTHSGSHKSYRPLCTLSFRLNHAIGGLNPWSYHLVNVLLHAAVTGLFTRFSKALLGDGYWTFMAGLMFASHPIHTEAVAGIVGRADVGASLFFLLSLLCYIKHCSTRGYSARTWGWFLGTGLCAGCSMLWKEQGVTVLAVSAVYDVFVFHRLKMKQILPTIYKRKNLSLFLSISLLTFWGTCLLGARLYWMGNKPPSFSNSDNPAADSDSLLARTLTFLYLPTKNLWLLLCPDTLSFDWSMDAVPLLKTVCDWRNLHTVAFYSGLLLLAYCGLKNPSLEGECNGKALTNGKQNANGHSCHSDVEYRNSEMKPSFASKVENGIKNCVPQRTQLPSTENIVILSLSLLIIPFIPATNLFFYVGFVIAERVLYIPSMGFCLLITVGARALYVKVQKRFLKSLVFYATATLIVFYGVKTAIRNGDWQNEEMLYRSGIKVNPAKAWGNLGNVLKSQSKISEAESAYRNALFYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGKTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGRYEEALSVYREAIQKMPRHFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGRKSEAEKFFLKAIELDPTKGNCYMHYGQFLLEESRLTEAAEMAKKAAELDNTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPDDVITQSNLRKLWNIMEKQGLKTSKT","sequence_length":836,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"3e993e633259dc16812e928bec21fa543886d09829bf4f457e4accda14d69723","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q56A06.json","taxon_id":"10090","uniprot_accession":"Q56A06","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/protein-o-mannosyl-transferase-tmtc-duf1736-ipr013618.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR013618","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/protein-o-mannosyl-transferase-tmtc-duf1736-ipr013618.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/tmtc-duf1736-pf08409.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF08409","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/tmtc-duf1736-pf08409.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/repeat/pfam/tpr-17-pf13431.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF13431","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/repeat/pfam/tpr-17-pf13431.yaml"}],"pfam_ids":["PF08409","PF13181","PF13431","PF13432"],"protein_name":"Protein O-mannosyl-transferase TMTC4","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAVLDTDLDHILPSSVLPPFWAKLVVGSVAIVCFARSYDGDFVFDDSEAIVNNKDLQAETPLGDLWHHDFWGSRLSSNTSHKSYRPLTVLTFRINYYLSGGFHPVGFHVVNILLHSGISVLMVDVFSVLFGGLQYTSKGRRLHLAPRASLLAALLFAVHPVHTECVAGVVGRADLLCALFFLLSFLGYCKAFRESNKEGAHSSTFWVLLSIFLGAVAMLCKEQGITVLGLNAVFDILVIGKFNVLEIVQKVLHKDKSLENLGMLRNGGLLFRMTLLTSGGAGMLYVRWRIMGTGPPAFTEVDNPASFADSMLVRAVNYNYYYSLNAWLLLCPWWLCFDWSMGCIPLIKSISDWRVIALAALWFCLIGLICQALCSEDGHKRRILTLGLGFLVIPFLPASNLFFRVGFVVAERVLYLPSVGYCVLLTFGFGALSKHTKKKKLIAAVVLGILFINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPTASGTKENYGLLRRKLELMQKKAV","sequence_length":741,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"c299d8d30fdb08394bafb6d1d7f9d2cfe196fd65e34e442930d85e1188b3797d","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q5T4D3.json","taxon_id":"9606","uniprot_accession":"Q5T4D3","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/protein-o-mannosyl-transferase-tmtc-duf1736-ipr013618.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR013618","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/protein-o-mannosyl-transferase-tmtc-duf1736-ipr013618.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/tmtc-duf1736-pf08409.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF08409","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/tmtc-duf1736-pf08409.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/repeat/pfam/tpr-17-pf13431.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF13431","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/repeat/pfam/tpr-17-pf13431.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/repeat/pfam/tpr-6-pf13174.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF13174","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/repeat/pfam/tpr-6-pf13174.yaml"}],"pfam_ids":["PF08409","PF13174","PF13181","PF13431"],"protein_name":"Protein O-mannosyl-transferase TMTC3","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MANINLKEITLIVGVVTACYWNSLFCGFVFDDVSAILDNKDLHPSTPLKTLFQNDFWGTPMSEERSHKSYRPLTVLTFRLNYLLSELKPMSYHLLNMIFHAVVSVIFLKVCKLFLDNKSSVIASLLFAVHPIHTEAVTGVVGRAELLSSIFFLAAFLSYTRSKGPDNSIIWTPIALTVFLVAVATLCKEQGITVVGICCVYEVFIAQGYTLPLLCTTAGQFLRGKGSIPFSMLQTLVKLIVLMFSTLLLVVIRVQVIQSQLPVFTRFDNPAAVSPTPTRQLTFNYLLPVNAWLLLNPSELCCDWTMGTIPLIESLLDIRNLATFTFFCFLGMLGVFSIRYSGDSSKTVLMALCLMALPFIPASNLFFPVGFVVAERVLYVPSMGFCILVAHGWQKISTKSVFKKLSWICLSMVILTHSLKTFHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEELLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLLETLALAPHEEYIQRHLNIVRDKISSSSFIEPIFPTSKISSVEGKKIPTESVKEIRGESRQTQIVKTSDNKSQSKSNKQLGKNGDEETPHKTTKDIKEIEKKRVAALKRLEEIERILNGE","sequence_length":915,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"f76e6efee5330d1a29ff751a047bfb113c15594abc388f1570bf3809fe16ce9c","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q6ZXV5.json","taxon_id":"9606","uniprot_accession":"Q6ZXV5","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Drosophila melanogaster","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/regulation-of-macromolecule-metabolic-process-go0060255.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0060255","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/regulation-of-macromolecule-metabolic-process-go0060255.yaml"}],"pfam_ids":["PF07719","PF08409","PF13181","PF13414","PF13432"],"protein_name":"Protein O-mannosyl-transferase Tmtc3","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSTNPNPGIHQYAPSTLPREREREGATNSPQRNLLEFLCICVACIVCYYNSTQCGLVFDDISAIRDNKDLRPHTPLINVFLNDFWGTPMRKEQSHKSYRPLTVLTFRFNYLLHALEPFGYHLVNLLLHLSVCLLWRRVCRLLLRQCAASGSNAISAPSSSSVSQLNTCAFVASLLFAVHPVHTEAVTGVVGRAELLSSICFLAAFLSYAKSVGDSGCPRRTNWLTLFGCFGSCLLASMLCKEQGITIAGICVVYELFVVHQLRPLHLCHFVLRLFDERTEQQSPKLANPSGIRRWSSSTLWKRLSFLVGITLTLLVGRVYVMGSQLPIFTRFDNPASAADTPERQLTYGYLIYLNCWLLLCPSLLCCDWTMGTVPLLQGFTDSRNITTLLTFLALGAMVAKTCFTRNLALSRTLIMCLGWMVLPFLPASNLFFPVGFVVAERILYMPSMGYCLLVAYGFEQLQRRGSLSWQRFSQAALAILLLTHALKTHQRNLDWRTEYSLFMSGVHVNQRNAKLYNNVGHALENEGKFEEALLYFQQAVRIQTDDIGAHINVGRTFNNLKRYAEAEQAYVQAKALFPQAKPGVSYHARIAPNHLNVFINLANLIAKNQTRLEEADHLYRQAISMRSDYVQAYINRGDILMKLNRTAQAQEVYEQALLYDNENADIYYNLGVVFLEQGKSQQAQVYFNKAIELYPEHEQALLNSAILLQELGGEEARRVSRSRLYKVLENDDQNEKVYFNLGMLAMDESSFDEAEQFFKRAIHLKADFRSALFNLALLLADTKRPLDAVPFLNQLIRHHPSHVKGLILLGDIYINHMKDLDEAEKCYRSILHYDPHNTQGLHNLCVVFVERKRLAKAAACLQYAQRLAPAEDYIGRHLQIVLARLQKINKLPESAPERKLAYEDYDPLEFKLPQDRPTHKSRKRS","sequence_length":926,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"dc2a7483d3ae4a8662a8280f8448395a90e3e19e9dfb1bca9a17e1cb5d53ba07","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q7K4B6.json","taxon_id":"7227","uniprot_accession":"Q7K4B6","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/outer-hair-cell-apoptotic-process-go1905584.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:1905584","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/outer-hair-cell-apoptotic-process-go1905584.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/positive-regulation-of-endoplasmic-reticulum-calcium-ion-concentration-go0032470.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0032470","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/positive-regulation-of-endoplasmic-reticulum-calcium-ion-concentration-go0032470.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/protein-o-mannosyl-transferase-tmtc-duf1736-ipr013618.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR013618","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/protein-o-mannosyl-transferase-tmtc-duf1736-ipr013618.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/tmtc-duf1736-pf08409.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF08409","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/tmtc-duf1736-pf08409.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/repeat/pfam/tpr-17-pf13431.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF13431","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/repeat/pfam/tpr-17-pf13431.yaml"}],"pfam_ids":["PF00515","PF08409","PF13431","PF13432"],"protein_name":"Protein O-mannosyl-transferase TMTC4","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MVELDADLDHIVPSVLPPFWAKLVVGFVSLLCFARSYDGDFVFDDSEAIVNNKDLQSDTPLGDLWHHDFWGSKLSSNTSHKSYRPLTVLTFRINYYLSGGFHPVGFHVVNILLHGSISILMLDVFSVLFGGLQYTGKGQRVHLAPRASLLATLLFAVHPVHTECVAGVVGRADLLCALFFLLSFLGYCQAFKETGNKEGTHSSTFWVLLSIFLGAVAMLCKEQGITVLGLNAVFDILVIGKLDILAAVRKVLHKDKSQENAGMFKNGGLLFRIALLTIGGTSMLYIRWKIMGTGPPAFTEVDNPASFADSMLVRAINYNYYYSLNAWLLLCPWWLCFDWSMGCIPLIKSVGDWRVIALAALWLCLIGLIFQALCSEDSCKRRILTLGLGFLVIPFLPASNLFFRVGFVVAERVLYLPSAGYCVLLTFGFGALSRHTKKKKPVAAIILGILLINALRCVIRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADQGNQTAAIKYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEEAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALQLIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPNVASYHGNLAVLYHRWGHLDSAKKHYEISLQLDPVAVGTKENYSLLRRKLEQTQKKDV","sequence_length":741,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"ff805855c6aa285f7a1ca130e81d4a0fb1c09fd5463f2cb22a40cef07d1c96e1","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q8BG19.json","taxon_id":"10090","uniprot_accession":"Q8BG19","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/dolichyl-phosphate-mannose-protein-mannosyltransferase-activity-go0004169.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0004169","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/dolichyl-phosphate-mannose-protein-mannosyltransferase-activity-go0004169.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/bud-outgrowth-involved-in-lung-branching-go0060447.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0060447","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/bud-outgrowth-involved-in-lung-branching-go0060447.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/protein-o-mannosyl-transferase-tmtc-duf1736-ipr013618.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR013618","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/protein-o-mannosyl-transferase-tmtc-duf1736-ipr013618.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/tmtc-duf1736-pf08409.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF08409","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/tmtc-duf1736-pf08409.yaml"}],"pfam_ids":["PF00515","PF08409","PF13174","PF13181"],"protein_name":"Protein O-mannosyl-transferase TMTC3","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MLEGKMADINFKEVTLIVSVVAACYWNSLFCGFVFDDVSAILDNKDLHPSTPLKTLFQNDFWGTPMSEERSHKSYRPLTVLTFRLNYLLSELKPMSYHLLNTVFHAVVSVIFLKVCRLFLDKRSSMIAALLFAVHPIHTEAVTGVVGRAELLSSVFFLAAFLSYTKSKGPDNSIVWTPIVLTVFLVAVATLCKEQGITVVGICCVYEVFVAQGYTLPMLCTVAGQFLRGKGSIPLSMLQTLVKLIVLMLSTLLLVVVRVQVIQSQLPVFTRFDNPAAVSPTPTRQLTFNYLLPVNAWLLLNPSELCCDWTMGTIPLIESFLDVRNLATFAFFCFLGALGIFSLRYPGDSSKTVLMALCLMALPFIPASNLFFPVGFVVAERVLYVPSMGFCILVAHGWQKISNKSVLKKLSWVCLSMVILTHALKTLHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFEKALKYFLQATHVQPDDIGAHMNVGRTYKNLNRSREAEASYMLAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVYIELKEPNEALKNFNRALELNPKHKLALFNSAILMQESGEVKLRPEARKRLLNYVNEEPQDANGYFNLGMLAMDDKKDSEAESWMKKAIKLQPDFRSALFNLALLYSQTAKELKALPILEELLKYYPDHTKGLILKGDILMNQKKDIPGAKKCFEKILEMDPSNVQGKHNLCVVYFEEKELLKAERCLVETLALAPHEEYIQRHLSIVRDRISSSGIVEQPLAPADKTPGTEEREEIPSEDVKEISSESRPPQILKTNNNRNSKSNKQSTENADQDAPHKTTKDIKEIEKKRVAALKRLEEIERILNGE","sequence_length":920,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"657f12fd668a1c8de1cf5c05048acf319a4db75590370bcdeb654904c28f1e73","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q8BRH0.json","taxon_id":"10090","uniprot_accession":"Q8BRH0","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/protein-o-mannosyl-transferase-tmtc-duf1736-ipr013618.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR013618","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/protein-o-mannosyl-transferase-tmtc-duf1736-ipr013618.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/tmtc-duf1736-pf08409.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF08409","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/tmtc-duf1736-pf08409.yaml"}],"pfam_ids":["PF00515","PF08409","PF13181","PF13424","PF13432"],"protein_name":"Protein O-mannosyl-transferase TMTC2","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MIAELVSSALGLALYLNTLSADFCYDDSRAIKTNQDLLPETPWTHIFYNDFWGTLLTHSGSHKSYRPLCTLSFRLNHAIGGLNPWSYHLVNVLLHAAVTGLFTSFSKILLGDGYWTFMAGLMFASHPIHTEAVAGIVGRADVGASLFFLLSLLCYIKHCSTRGYSARTWGWFLGSGLCAGCSMLWKEQGVTVLAVSAVYDVFVFHRLKIKQILPTIYKRKNLSLFLSISLLIFWGSSLLGARLYWMGNKPPSFSNSDNPAADSDSLLTRTLTFFYLPTKNLWLLLCPDTLSFDWSMDAVPLLKTVCDWRNLHTVAFYTGLLLLAYYGLKSPSVDRECNGKTVTNGKQNANGHSCLSDVEYQNSETKSSFASKVENGIKNDVSQRTQLPSTENIVVLSLSLLIIPFVPATNLFFYVGFVIAERVLYIPSMGFCLLITVGARALYVKVQKRFLKSLIFYATATLIVFYGLKTAIRNGDWQNEEMLYRSGIKVNPAKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPDDVITQSNLRKLWNIMEKQGLKTSKT","sequence_length":836,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"7eaa5f5623ec9f01b39b738c6504a13a18105ffe11d68a15e26b649efcb8e312","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q8N394.json","taxon_id":"9606","uniprot_accession":"Q8N394","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Drosophila melanogaster","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/protein-o-mannosyl-transferase-tmtc-duf1736-ipr013618.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR013618","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/protein-o-mannosyl-transferase-tmtc-duf1736-ipr013618.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/tmtc-duf1736-pf08409.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF08409","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/tmtc-duf1736-pf08409.yaml"}],"pfam_ids":["PF08409","PF13414","PF13424","PF13432"],"protein_name":"Protein O-mannosyl-transferase Tmtc4","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MLDLVHKATLHSMVCQAILVLICLLCYGCGGLSGAKFVFDDTVAIVKNRDVNSLPTNWTAIFTHDFWGASLLSSDSHKSFRPLTTLMFHCEYALLGLSAAHMKFLNLLLHCVNTLLMWRLIRSLYVPEVSTARWAILSAALFAAHPIHTEAVSGVVGRAELMFGMIHLLCLLLTVANTGRLGPQTGGLIMLLTAVGMLFKESAVTIPMSCVLLDYFQNGYYHLRFKDQWSLLRTRISYLFYLLGTLGLLTARLWWQDFETPTFKEVDNPVAHNEHVLTRGLSQQYLLVMNIWLMLCPHWLCYDWALGCVKLVTNIWDLRLQGVIGFYSIVLVALMNFRRLPGMMLALGLMIVPFLPASGIICVGFVIAERTLYVPSIGFCLLSIYGFLYWYDSSTENTHWRTALRILLMLLFSVMMVRTRQRATDWLNEEQLFKSALQVCPDNAKVHYNIARLATDMGNNTKAFQHYHRAIELYPNYESALMNLGNLYREHGQLSTAEEYIRLALQAYPAFPAAWMNLGIVQSAQGKYDKALASYEKALKYRANFAVCYYNMGNLYLEQKRYAEALHHWQHAVALNPRQPKAWANILTMLDNKGLQDDALRISNQALQHLPNDVSILFIRANVLGKLKHYTEAEAIYKRVIELEPHNTLYHTNLGVLYHRWDKTQEAIEAYRTAISISAARATTARENLSKLLKRLEREAQVMQR","sequence_length":705,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"a190f3074d7d2f962669429132456dfb0d18c111819933c6bfcb4b16e90ef887","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9VF81.json","taxon_id":"7227","uniprot_accession":"Q9VF81","uniprot_release":"2026_03"}],"pfam_id":"PF08409","short_name":"TMTC_DUF1736","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}