{"cross_mech":[],"family":{"alphafold_models":4552,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"The FIST N domain is a novel sensory domain, which is present in signal transduction proteins from Bacteria, Archaea and Eukarya. Chromosomal proximity of FIST-encoding genes to those coding for proteins involved in amino acid metabolism and transport suggest that FIST domains bind small ligands, such as amino acids [[cite:PUB00044261]].","domain_architectures":104,"interpro_id":"IPR013702","known_evidence_count":null,"matches":6781,"name":"FIST N domain","partial_evidence_count":null,"pfam_id":"PF08495","proteins":6777,"proteomes":5036,"short_name":"FIST","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08495","structures":0,"taxa":8763,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF08495.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":4552,"domain_architectures":104,"matches":6781,"proteins":6777,"proteomes":5036,"structures":0,"taxa":8763},"curation_status":"SEEDED","description":"The FIST N domain is a novel sensory domain, which is present in signal transduction proteins from Bacteria, Archaea and Eukarya. Chromosomal proximity of FIST-encoding genes to those coding for proteins involved in amino acid metabolism and transport suggest that FIST domains bind small ligands, such as amino acids [[cite:PUB00044261]].","id":"Pfam:PF08495","interpro_id":"InterPro:IPR013702","name":"FIST N domain","pfam_id":"PF08495","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"FIST","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08495"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF08495.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"b5b87b5c197adb81f059e5eb8afc99142feb361bc9209b1f6a5a946e8ce611ad"}},"protein_examples":{"candidate_count":4,"discovery_scanned":true,"example_count":4,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/fist-pf08495.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF08495","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/fist-pf08495.yaml"}],"pfam_ids":["PF08495","PF10442"],"protein_name":"Uncharacterized protein Mb0898c","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MRIGVGVCTTPDARQAAVEAAGQARDELAGEAPSLAVLLGSRAHTDRAADVLSAVLQMIDPPALVGCIAQAIVAGRHEIEDEPAVVVWLASGLAAETFQLDFVRTGSGALITGYRFDRTARDLHLLLPDPYTFPSNLLIEHPNTDLPGTAVVGGVVSGGRRRGDTRLFRDHDVLTSGVVGVRLPGMRGVPVVSQGCRPIGYPYIVTGADGILITELGGRPPLQRLREIVEGLSPDERALVSHGLQIGIVVDEHLAAPGQGDFVIRGLLGADPSTGSIEIDEVVQVGATMQFQVRDAAGADKDLRLTVERAAARLPGRAAGALLFTCNGRGRRMFGVADHDASTIEELLGGIPLAGFFAAGEIGPIAGRNALHGFTASMALFVDDME","sequence_length":386,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"cdfdf82afc8b0a7811a8edbdddf74002e85a86d7d884b608499ae3674de7fd0d","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P0A5D4.json","taxon_id":"233413","uniprot_accession":"P0A5D4","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/fist-pf08495.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF08495","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/fist-pf08495.yaml"}],"pfam_ids":["PF08495","PF10442"],"protein_name":"Uncharacterized protein Rv0628c","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MRIGVGVSTAPDVRRAAAEAAAHAREELAGGTPALAVLLGSRSHTDQAVDLLAAVQASVEPAALIGCVAQGIVAGRHELENEPAVAVWLASGPPAETFHLDFVRTGSGALITGYRFDRTAHDLHLLLPDPYSFPSNLLIEHLNTDLPGTTVVGGVVSGGRRRGDTRLFRDRDVLTSGLVGVRLPGAHSVSVVSQGCRPIGEPYIVTGADGAVITELGGRPPLHRLREIVLGMAPDEQELVSRGLQIGIVVDEHLAVPGQGDFLIRGLLGADPTTGAIGIGEVVEVGATVQFQVRDAAAADKDLRLAVERAAAELPGPPVGGLLFTCNGRGRRMFGVTDHDASTIEDLLGGIPLAGFFAAGEIGPVAGHNALHGFTASMALFVD","sequence_length":383,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"611bf7e0d2ad563425008cf2847c54591bd5e1fc56f0d0f71641f0ff0e1a9287","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P9WKS7.json","taxon_id":"83332","uniprot_accession":"P9WKS7","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/fist-c-domain-ipr019494.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR019494","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/fist-c-domain-ipr019494.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/fist-domain-n-terminal-ipr013702.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR013702","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/fist-domain-n-terminal-ipr013702.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/transcription-regulator-trmb-n-terminal-ipr002831.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR002831","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/transcription-regulator-trmb-n-terminal-ipr002831.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/trmb-pf01978.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF01978","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/trmb-pf01978.yaml"}],"pfam_ids":["PF01978","PF08495","PF10442"],"protein_name":"Uncharacterized protein MJ1623","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MIYIHKKIKNPIKDGIEIGEEIKRNVGRASLIIFITSILERDKLKQVFDGMKQHIPLDNLIGCSTGGTFSGKDYIKEDGVLILAFDEYYKSAISCEKVDREAEYVGKKIADKIKTCIRDKYPKLDIDDNFLGFVFFDWNVDSEQEILDVLGRELTIPIIGGTAADDGSFDKFFQIYKGEVVKDCCVFGVVGGKLKFDLIYGHGYEPTDIYARVTKAEGKVVYELDGKPAYQRYLEMLSEYTKLPMDIIKKYFYRDLRRLDFYLVHPLGFMDINGNYITAFLERVEENTLVFRRDILEGSFLVLMKTDIEKQVKSIVDELKKAEDFENPLIFINECYGREVLKNSMFREFEEDILKYFLNFYKAGKKVEEYVIEDNCIGWLSYGETIAKDLIRFHNNLSFTGVIFELSQSSNINWREELKNFNFEDDEIEVIVNLINKQLTAKELLQLTNLSQTKLYHILNKLEKEGIIKSVSGKPKLYYIDNIKEILQKTHEKIEHENMVKKIKRKKLLRLL","sequence_length":512,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"982b84ce79fdb8a554c2fbd87b3468095668d29fd6c6e5f560841a1cf14867f1","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q59017.json","taxon_id":"243232","uniprot_accession":"Q59017","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/fist-c-pf10442.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF10442","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/fist-c-pf10442.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/fist-pf08495.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF08495","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/fist-pf08495.yaml"}],"pfam_ids":["PF00563","PF00990","PF08495","PF10442"],"protein_name":"Cyclic di-GMP phosphodiesterase CdpA","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MFTVSRLIPDLASANQVLETMDLPHGQSILVQIFSPLSREHVVQLARLIRSRHPQACLLGCSTEEVIFQGEVHHQVTLLQITVFEQTYLSRAVVDYSDDEAADAERLARQLELTSMSRAVVCFSWQMDTLQVARFALRDTQGAPVPVAGGAAKQTPSGRWVLLDEACYQNASVAIALHGEALYVETGGYTEWQPVGRTYRVTAVEGDRVLRLDDEPIEAIYQRNLGAQADLPHDWLISFPLMKGECRHQDLYLPLGLAEEGGLRFNRPLALQDEVRFCFDHPSLTLERVYLTAQQLQAKQCQQVWVFNCALRLNFMHENHELQPLQAVAPTDGCYCWGELLYEHGQQQVMHHSMTFLALREGAVRDDLVPIPLPSYPEGMTSPLFNLIRHAFHDLDAMTDNLAQQIRAQTSLLTASYRRDRRTGLPNRVVLRERLANFAANEHLIALKVTNFNQINEKYGYPVGDKLLRDLSEQFQVFLDQKLAGQSGLYAIGVGEWATVFRAKLDGKSIHSHFYQFVEQLEHVNFEPYGLPNVDYLSISLCAGLVSQGDFAEHSPDELLLRAIEARRYAFNNNHHFCNAARLKVQESVRQERLNWLSRVSRAVVRDDVVVYAQPICQARSHIVASYECLVRIEDEGEIILPGNFLPIITDTHLYTRLSRQMITHTFNMMRHRPEAFSINLSPQDLMSERTLQHLEAAIKSVADPARVGLEVLESEQIKDYGRMIEVCNHFRTLGATIIVDDFGSGYSNIDEIVKLEPQVIKLDGSLIRNIDQDVKQRRIAEQLVKLCQVLNAKTVAEFVHNQTVCRISEDMGVDYLQGYFLGRPSRLG","sequence_length":829,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"1310492702e8c3da8992ceffcdffe062cd33827fad727a52e25cf681962f37ad","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9KVL2.json","taxon_id":"243277","uniprot_accession":"Q9KVL2","uniprot_release":"2026_03"}],"pfam_id":"PF08495","short_name":"FIST","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
