{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF08508","protein_label":"Golgi/endosome-localized DSC protein 1","reviewed":true,"short_name":"DUF1746","source_category":"function/localization/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/localization/go/dsc-e3-ubiquitin-ligase-complex-go0044695.yaml","source_record_id":"GO:0044695","source_record_label":"Dsc E3 ubiquitin ligase complex","source_section":"canonical_examples","taxon_id":"NCBITaxon:559292","taxon_label":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","uniprot_accession":"Q06104","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF08508","protein_label":"Golgi/endosome-localized DSC protein 1","reviewed":true,"short_name":"DUF1746","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/egad-pathway-go0140624.yaml","source_record_id":"GO:0140624","source_record_label":"EGAD pathway","source_section":"canonical_examples","taxon_id":"NCBITaxon:559292","taxon_label":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","uniprot_accession":"Q06104","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF08508","protein_label":"Golgi/endosome-localized DSC protein 1","reviewed":true,"short_name":"DUF1746","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf1746-ipr013715.yaml","source_record_id":"InterPro:IPR013715","source_record_label":"Domain of unknown function DUF1746","source_section":"canonical_examples","taxon_id":"NCBITaxon:559292","taxon_label":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","uniprot_accession":"Q06104","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF08508","protein_label":"","reviewed":null,"short_name":"DUF1746","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf1746-ipr013715.yaml","source_record_id":"InterPro:IPR013715","source_record_label":"Domain of unknown function DUF1746","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF08508","protein_label":"DSC E3 ubiquitin ligase complex subunit D","reviewed":true,"short_name":"DUF1746","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf1746-pf08508.yaml","source_record_id":"Pfam:PF08508","source_record_label":"Fungal domain of unknown function (DUF1746)","source_section":"canonical_examples","taxon_id":"NCBITaxon:451804","taxon_label":"Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)","uniprot_accession":"B0XYF7","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF08508","protein_label":"DSC E3 ubiquitin ligase complex subunit 4","reviewed":true,"short_name":"DUF1746","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf1746-pf08508.yaml","source_record_id":"Pfam:PF08508","source_record_label":"Fungal domain of unknown function (DUF1746)","source_section":"canonical_examples","taxon_id":"NCBITaxon:284812","taxon_label":"Schizosaccharomyces pombe (strain 972 / ATCC 24843)","uniprot_accession":"O14175","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF08508","protein_label":"Golgi/endosome-localized DSC protein 1","reviewed":true,"short_name":"DUF1746","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf1746-pf08508.yaml","source_record_id":"Pfam:PF08508","source_record_label":"Fungal domain of unknown function (DUF1746)","source_section":"canonical_examples","taxon_id":"NCBITaxon:559292","taxon_label":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","uniprot_accession":"Q06104","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF08508","protein_label":"","reviewed":null,"short_name":"DUF1746","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf1746-pf08508.yaml","source_record_id":"Pfam:PF08508","source_record_label":"Fungal domain of unknown function (DUF1746)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":1116,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function","description_says_unknown_function","domain_of_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":3,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":4},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This is a fungal domain of unknown function. This domain can be found in DSC E3 ubiquitin ligase complex subunit 4 (Dsc4) from S. pombe, a component of the DSC E3 ubiquitin ligase complex required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. The complex plays also an important role in the multivesicular body (MVB) pathway and functions in a post-endoplasmic reticulum pathway for protein degradation [[cite:PUB00075404]]. This domain is also found in GLD1 from S. cerevisiae, also a component of the DSC E3 ubiquitin ligase complex involved in the targeting of the DSC complex to the Golgi apparatus and endosome membranes via the AP3 pathway to ubiquitinate Golgi/endosome membrane proteins [[cite:PUB00098082]].","domain_architectures":20,"interpro_id":"IPR013715","known_evidence_count":null,"matches":1353,"name":"Fungal domain of unknown function (DUF1746)","partial_evidence_count":null,"pfam_id":"PF08508","proteins":1326,"proteomes":1282,"short_name":"DUF1746","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08508","structures":0,"taxa":2736,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF08508.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1116,"domain_architectures":20,"matches":1353,"proteins":1326,"proteomes":1282,"structures":0,"taxa":2736},"curation_status":"SEEDED","description":"This is a fungal domain of unknown function. This domain can be found in DSC E3 ubiquitin ligase complex subunit 4 (Dsc4) from S. pombe, a component of the DSC E3 ubiquitin ligase complex required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. The complex plays also an important role in the multivesicular body (MVB) pathway and functions in a post-endoplasmic reticulum pathway for protein degradation [[cite:PUB00075404]]. This domain is also found in GLD1 from S. cerevisiae, also a component of the DSC E3 ubiquitin ligase complex involved in the targeting of the DSC complex to the Golgi apparatus and endosome membranes via the AP3 pathway to ubiquitinate Golgi/endosome membrane proteins [[cite:PUB00098082]].","id":"Pfam:PF08508","interpro_id":"InterPro:IPR013715","name":"Fungal domain of unknown function (DUF1746)","pfam_id":"PF08508","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF1746","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08508"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF08508.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"473456b8dd6459d4f4e3cc721053a47f0a18d456750551835ff6f0d1ba6c0781"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf1746-pf08508.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF08508","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf1746-pf08508.yaml"}],"pfam_ids":["PF08508"],"protein_name":"DSC E3 ubiquitin ligase complex subunit D","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MTTPDAFRDAEYIADVSGISYGNVANLTEQDANVVPRENERMRKLQLAAKVAFIDRLLRDLDILIYCELSALYYMDCSVILFAIRAIVQLIFFTPKAPPFDPTRNQPFIGAIFVSNIFCMIFHNFFTHPEASEATRGYLHGGLLIDFIGQKAPIPLFRLFLLDFLVLILDLVMLGLIVERVKTTGQTSTTSTEILRVQDHDSEERGVHRTRPESRSSVVGAELDETDGHITRANAGVGEQAEHTQLLADPSEDGHTPGAKNSHPLDAFSSGEAVIMNLGLFDVIRDQWKYSTTAPPARTSSYIPSDQTAAFLRARFGLQVGPDGRVQRIQS","sequence_length":331,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"7c52034b6535df9843fa98c3169eaf2fdc4214779f6bd39b1d27024cee0d1e4f","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/B0XYF7.json","taxon_id":"451804","uniprot_accession":"B0XYF7","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Schizosaccharomyces pombe (strain 972 / ATCC 24843)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf1746-pf08508.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF08508","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf1746-pf08508.yaml"}],"pfam_ids":["PF08508"],"protein_name":"DSC E3 ubiquitin ligase complex subunit 4","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MDTIVLDQRGEVFSFFRSLDMLCYAIIAQQYFQDPTVLLLLLKVFVQLSYLTPKPFSQLNALPLFYPLLLNFLISLMVRMFFNLPTAGESLDGYLYGGSIINFIGEKNESSRIDFITSDLVLFCLQIFMALILIASNKRPTQASHIQASQSGLSNVDGDEEPSDLITEDSRDTQQGQRQEDLQRQLENERSRLIARFSHSLYSFQHGLSFGSPQNRNTPLQRQSADSYSTPVCIEVDSEDWKDLVWKSQYATENANTNSINNSPLSSNTTGVPNSVLTNPI","sequence_length":281,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"2f2daab2e20f6d37a18f33a5c127941c57f6e8fdd7eb3990db3c9ce6ec183b99","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/O14175.json","taxon_id":"284812","uniprot_accession":"O14175","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/localization/go/dsc-e3-ubiquitin-ligase-complex-go0044695.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0044695","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/localization/go/dsc-e3-ubiquitin-ligase-complex-go0044695.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/egad-pathway-go0140624.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0140624","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/egad-pathway-go0140624.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf1746-ipr013715.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR013715","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/domain-of-unknown-function-duf1746-ipr013715.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf1746-pf08508.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF08508","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf1746-pf08508.yaml"}],"pfam_ids":["PF08508"],"protein_name":"Golgi/endosome-localized DSC protein 1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MDNFESTAEGNLSIGNKRVYELRKRNFQRNLVNNLSFLGYVLISLEYIKYDRTVWTLITRAIVQSLISSPFPSDAKLRRLATLGADNNTTGVATLPGGRSIRFPGMFGTEMLYNSSSEAEQQDHDDTAIVSMKKQIRKFLFHGCLSLNMLFIILTILFPIDFFEPLSGSEPVDDGPKNTPSPFSNSDGLLLGERRGGLFLQMIGERLPKSNFSGNLGLVMFEFSILIVQFTLFSLTCVVLADLDFEEPERLEPVNSDGYDGSVIVARIPLNKTMNAILNDGNINDNNENASNSV","sequence_length":294,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"42811cf94fecdd6880eecacef56e3860b247301c25049c54f2e3e542ee344cb6","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q06104.json","taxon_id":"559292","uniprot_accession":"Q06104","uniprot_release":"2026_03"}],"pfam_id":"PF08508","short_name":"DUF1746","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}