{"cross_mech":[],"family":{"alphafold_models":1470,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This is a family of fungal proteins identified as mitochondrial fission factors (mitofissin, also referred to as Atg44) which are essential for mitophagy. Mitofissin directly binds to lipid membranes to drive mitochondrial fission required for mitophagy [[cite:PUB00151415]].","domain_architectures":28,"interpro_id":"IPR013726","known_evidence_count":null,"matches":1787,"name":"Mitofissin","partial_evidence_count":null,"pfam_id":"PF08520","proteins":1770,"proteomes":1272,"short_name":"Mitofissin","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08520","structures":1,"taxa":2767,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF08520.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1470,"domain_architectures":28,"matches":1787,"proteins":1770,"proteomes":1272,"structures":1,"taxa":2767},"curation_status":"SEEDED","description":"This is a family of fungal proteins identified as mitochondrial fission factors (mitofissin, also referred to as Atg44) which are essential for mitophagy. Mitofissin directly binds to lipid membranes to drive mitochondrial fission required for mitophagy [[cite:PUB00151415]].","id":"Pfam:PF08520","interpro_id":"InterPro:IPR013726","name":"Mitofissin","pfam_id":"PF08520","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"Mitofissin","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08520"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF08520.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"6da6f58265a19ffdd9f50bc541fd67985ed5bcefdb2ca3e196fcac2b1ed930c6"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/mitofissin-pf08520.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF08520","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/mitofissin-pf08520.yaml"}],"pfam_ids":["PF08520"],"protein_name":"Mitofissin","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MTLVGKLVHISIDLVLVSTCLAGIKRNTGLTPKLETLDNQTMRNYMKRYLNLGESVYDYSVATCGSSTYFARK","sequence_length":73,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"573db0c8fd26c26ebeeee403f5f2eabf02ba324116366b7b67020d13bada17b4","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q2V2P4.json","taxon_id":"559292","uniprot_accession":"Q2V2P4","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/mitofissin-pf08520.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF08520","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/mitofissin-pf08520.yaml"}],"pfam_ids":["PF08520"],"protein_name":"Uncharacterized protein YKL018C-A","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MLGMIRWVVEGTLVAMLLSAIRRETGMIFFYNQYQLGGWIHRYLSWGEMCYTRTLKMVKRSKFFRKQLNEDGFGRINDSGPKRRGRDQSQYSSRFVELD","sequence_length":99,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"85d30440238bc2891ce128a7bf300dcecd17588c1c95188955d5c29ea79b24ca","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q3E7A7.json","taxon_id":"559292","uniprot_accession":"Q3E7A7","uniprot_release":"2026_03"}],"pfam_id":"PF08520","short_name":"Mitofissin","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}