{"cross_mech":[],"family":{"alphafold_models":5817,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"Cmc1 is a metallo-chaperone like protein which is known to localise to the inner mitochondrial membrane in Saccharomyces cerevisiae. It is essential for full expression of cytochrome c oxidase and respiration [[cite:PUB00044676]]. Cmc1 contains two Cx9C motifs and is able to bind copper(I). Cmc1 is thought to play a role in mitochondrial copper trafficking and transfer to cytochrome c oxidase [[cite:PUB00044676]].","domain_architectures":81,"interpro_id":"IPR013892","known_evidence_count":null,"matches":6771,"name":"Cytochrome c oxidase biogenesis protein Cmc1 like","partial_evidence_count":null,"pfam_id":"PF08583","proteins":6753,"proteomes":3205,"short_name":"Cmc1","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08583","structures":3,"taxa":8526,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF08583.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":5817,"domain_architectures":81,"matches":6771,"proteins":6753,"proteomes":3205,"structures":3,"taxa":8526},"curation_status":"SEEDED","description":"Cmc1 is a metallo-chaperone like protein which is known to localise to the inner mitochondrial membrane in Saccharomyces cerevisiae. It is essential for full expression of cytochrome c oxidase and respiration [[cite:PUB00044676]]. Cmc1 contains two Cx9C motifs and is able to bind copper(I). Cmc1 is thought to play a role in mitochondrial copper trafficking and transfer to cytochrome c oxidase [[cite:PUB00044676]].","id":"Pfam:PF08583","interpro_id":"InterPro:IPR013892","name":"Cytochrome c oxidase biogenesis protein Cmc1 like","pfam_id":"PF08583","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"Cmc1","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08583"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF08583.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"64b35aa25a3d2285ed3cddedc0384340be52ec50591fb44937a68e922ae504a6"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/cmc1-pf08583.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF08583","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/cmc1-pf08583.yaml"}],"pfam_ids":["PF08583"],"protein_name":"COX assembly mitochondrial protein","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MEQNKDPQMISKHSSRLPIWVLSPREEQQARKNLKTETYKKCANFVQAMADCAKANGMKVFPTCDKQRDEMKSCLLFYQTDEKYLDGERDKIVLEKINKLEKLCQKQSSTK","sequence_length":111,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"91fb397c63fcfc95f41f0d681a3459494486d5307c7a8322be759ef5f67d0a7c","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/P36064.json","taxon_id":"559292","uniprot_accession":"P36064","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/cmc1-pf08583.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF08583","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/cmc1-pf08583.yaml"}],"pfam_ids":["PF08583"],"protein_name":"COX assembly mitochondrial protein 2","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MHPQLEAERFHSCLDFINALDKCHQKEYYKRIFGLCNNEKDALNKCLKEASLNNKKRAVIESRIKRADVEKRWKKIEEEEYGEDAILKTILDRQYAKKKQESDNDANSK","sequence_length":109,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"9954e75b43104244d7ce6cf53dba16bf78771bc741d949fdf54a45a1feece5c2","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q3E7A4.json","taxon_id":"559292","uniprot_accession":"Q3E7A4","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/cmc1-pf08583.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF08583","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/cmc1-pf08583.yaml"}],"pfam_ids":["PF08583"],"protein_name":"COX assembly mitochondrial protein homolog","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MALDPADQHLRHVEKDVLIPKIMREKAKERCSEQVQDFTKCCKNSGVLMVVKCRKENSALKECLTAYYNDPAFYEECKMEYLKEREEFRKTGIPTKKRLQKLPTSM","sequence_length":106,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"c6d74afd291f0b6ea8520ae0f52e3b35618cba7b0465748e43e1caa1dca22b90","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q7Z7K0.json","taxon_id":"9606","uniprot_accession":"Q7Z7K0","uniprot_release":"2026_03"}],"pfam_id":"PF08583","short_name":"Cmc1","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
