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It functions in the SpoIIGA-dependent proteolytic activation of sigma E in the mother cell [[cite:PUB00162567]].","domain_architectures":1,"interpro_id":"IPR014794","known_evidence_count":null,"matches":1213,"name":"Sporulation protein SpoIIT","partial_evidence_count":null,"pfam_id":"PF08680","proteins":1213,"proteomes":1173,"short_name":"SpoIIT","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08680","structures":1,"taxa":1690,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF08680.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":766,"domain_architectures":1,"matches":1213,"proteins":1213,"proteomes":1173,"structures":1,"taxa":1690},"curation_status":"SEEDED","description":"This entry represents sporulation protein SpoIIT and related proteins. TATA-box_bdg is a family of bacterial proteins.SpoIIT from Bacillus subtilis contains a circularly permuted TATA-box binding protein-like fold. It participates in cell-cell signalling pathways during sporulation. It functions in the SpoIIGA-dependent proteolytic activation of sigma E in the mother cell [[cite:PUB00162567]].","id":"Pfam:PF08680","interpro_id":"InterPro:IPR014794","name":"Sporulation protein SpoIIT","pfam_id":"PF08680","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"SpoIIT","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08680"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF08680.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"79a13847268bed2057ed758a2c868df9ca3ce124c9652d0f3906fc47d2f7aa76"}},"protein_examples":{"candidate_count":1,"discovery_scanned":true,"example_count":1,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Bacillus subtilis (strain 168)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/spoiit-pf08680.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF08680","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/spoiit-pf08680.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/sporulation-protein-spoiit-like-ipr036209.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR036209","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/sporulation-protein-spoiit-like-ipr036209.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/ywmb-like-3-30-2030-10.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:3.30.2030.10","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/ywmb-like-3-30-2030-10.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/ywmb-like-3-30-360-40.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:3.30.360.40","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/ywmb-like-3-30-360-40.yaml"}],"pfam_ids":["PF08680"],"protein_name":"Sporulation protein SpoIIT","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MKKKQVSHAIIISVMLSFVIAVFHTIHASELTPLAQMAEGMERQDVSIDKWTLHAKQNLSLTEKEFYQKVQRLKQEYRQYDWVIAREDKMIKAIGTYTDKKNRTSFRLQLVTTLKKHNPTSYLLYEQMSLETPDSWNDTYEQFERETLGIFQEKVVIFTCLNGHLDDNMNIVLQKKANQLLNEFQARSVEHVVEPNFVSISAFTDEWEEYIMTSKHKMNLQIALRSAGMGGKHTVTVGTPIVTTEY","sequence_length":246,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"17f230dfcee54afe83d8bc4646a8d465f55829911995026d054926e739affc6b","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/O32277.json","taxon_id":"224308","uniprot_accession":"O32277","uniprot_release":"2026_03"}],"pfam_id":"PF08680","short_name":"SpoIIT","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}