{"cross_mech":[],"family":{"alphafold_models":3302,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This is a family of eukaryotic nucleolar proteins that are involved in pre-rRNA processing [[cite:PUB00035397]].","domain_architectures":84,"interpro_id":"IPR014810","known_evidence_count":null,"matches":3898,"name":"Fcf2 pre-rRNA processing","partial_evidence_count":null,"pfam_id":"PF08698","proteins":3864,"proteomes":3264,"short_name":"Fcf2","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08698","structures":45,"taxa":8708,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF08698.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":3302,"domain_architectures":84,"matches":3898,"proteins":3864,"proteomes":3264,"structures":45,"taxa":8708},"curation_status":"SEEDED","description":"This is a family of eukaryotic nucleolar proteins that are involved in pre-rRNA processing [[cite:PUB00035397]].","id":"Pfam:PF08698","interpro_id":"InterPro:IPR014810","name":"Fcf2 pre-rRNA processing","pfam_id":"PF08698","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"Fcf2","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08698"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF08698.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"04f93e7d6dd965f6af4747ed56061cc58d1ff2a53053c4ddf589484a8e27d3df"}},"protein_examples":{"candidate_count":4,"discovery_scanned":true,"example_count":4,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Bos taurus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/fcf2-pf08698.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF08698","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/fcf2-pf08698.yaml"}],"pfam_ids":["PF08698"],"protein_name":"Deoxynucleotidyltransferase terminal-interacting protein 2","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MVVTRSARPQARNEATSVESLRQKNSAVTRLHVHPKGRKGSSPDNPNTTESQTTPERSPAPKTRKSGTTGSLPEMNKPATDGEISEAESDCSSVPEVQDPVFRVTRRRQILVAGTPVSSVRKRLKITRVSESHTEEVVSEADSHVSGISRIMPPTEITTRRSKAKSQREPKQESHVEVISDAESSCSDISFSGIATRRTTRSMQRKLQAQTEENNTKIVLENEKEIIHTPVNLEDSVNRRTSRLLARSLSQINKPNFSNNEIYNDPDDSFFGISGKKLAVKKTRNFTIREEKQDSISPLKEITKQNCKSLDEEAKKIIDGGKEGNEKNSQLNLSEFQDTGLQQLVSQRHSTPESDKTTSESSTLNHEAVMKSLAQTFAVVEMDRWNEERKNAIKTSDCSEPGDGSYSDSDEECTVIGVSEDMSKEKEVDSESDTKPSNLEFNTTQDKDDSVLLVLSSDESQQSEHSENEEDTVCFVENNGNKESLNGDSENLSHDNALFVIDTTPGLSADKNFYLDEEDKAGEVATEEEEEEEEEESEEELSDHDRNKDNEFSDEDNLLSNTKSKLLKLMSSSIDTGLNIKELGGLYINFNADKVQLNKRTLTQMKEKRKDELLQKTVITPEFEKNYCVPPYSESKYKLQKKRRQERQKTAGDGWFGMKAPELTDELKNDLKALKMRASMDPKRFYKKNDRDGFPKYFQIGTIVDNPADFYHSRVPKKQRKRTIVEELLADSEFRRYNRRKYSEIMAEKAANAAGKKFRKKKKFRN","sequence_length":766,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"7a8497da4aa1930d9276d80396dfe556c4b7c8f4bbcf34845fdaa8fb54b7cff9","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q0P5H2.json","taxon_id":"9913","uniprot_accession":"Q0P5H2","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/fcf2-pre-rrna-processing-c-terminal-ipr014810.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR014810","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/fcf2-pre-rrna-processing-c-terminal-ipr014810.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/fcf2-pf08698.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF08698","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/fcf2-pf08698.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:Q12035","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF08698"],"protein_name":"rRNA-processing protein FCF2","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"e3de51e9620ee30757995c3a34334d5f8b693f2fc007c0b0e437c38ce639b2ee","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MDQSVEDLFGALRDASASLEVKNSAKEQVSLQQEDVLQIGNNDDEVEIESKFQEIETNLKKLPKLETGFDALANKKKKKNVLPSVETEDKRKPNKSDKNDNDWFTLPKPDDNMRREVQRDLLLIKHRAALDPKRHYKKQRWEVPERFAIGTIIEDKSEFYSSRMNRKERKSTILETLMGDEASNKYFKRKYNEIQEKSTSGRKAHYKKMKEMRKKRR","sequence_length":217,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"e3de51e9620ee30757995c3a34334d5f8b693f2fc007c0b0e437c38ce639b2ee","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q12035.json","taxon_id":"559292","uniprot_accession":"Q12035","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/fcf2-pre-rrna-processing-c-terminal-ipr014810.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR014810","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/fcf2-pre-rrna-processing-c-terminal-ipr014810.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/fcf2-pf08698.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF08698","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/fcf2-pf08698.yaml"}],"pfam_ids":["PF08698"],"protein_name":"Deoxynucleotidyltransferase terminal-interacting protein 2","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MVVTRSARAKASIQAASAESSGQKSFAANGIQAHPESSTGSDARTTAESQTTGKQSLIPRTPKARKRKSRTTGSLPKGTEPSTDGETSEAESNYSVSEHHDTILRVTRRRQILIACSPVSSVRKKPKVTPTKESYTEEIVSEAESHVSGISRIVLPTEKTTGARRSKAKSLTDPSQESHTEAISDAETSSSDISFSGIATRRTRSMQRKLKAQTEKKDSKIVPGNEKQIVGTPVNSEDSDTRQTSHLQARSLSEINKPNFYNNDFDDDFSHRSSENILTVHEQANVESLKETKQNCKDLDEDANGITDEGKEINEKSSQLKNLSELQDTSLQQLVSQRHSTPQNKNAVSVHSNLNSEAVMKSLTQTFATVEVGRWNNNKKSPIKASDLTKFGDCGGSDDEEESTVISVSEDMNSEGNVDFECDTKLYTSAPNTSQGKDNSVLLVLSSDESQQSENSENEEDTLCFVENSGQRESLSGDTGSLSCDNALFVIDTTPGMSADKNFYLEEEDKASEVAIEEEKEEEEDEKSEEDSSDHDENEDEFSDEEDFLNSTKAKLLKLTSSSIDPGLSIKQLGGLYINFNADKLQSNKRTLTQIKEKKKNELLQKAVITPDFEKNHCVPPYSESKYQLQKKRRKERQKTAGDGWFGMKAPEMTNELKNDLKALKMRASMDPKRFYKKNDRDGFPKYFQIGTIVDNPADFYHSRIPKKQRKRTIVEELLADSEFRRYNRRKYSEIMAEKAANAAGKKFRKKKKFRN","sequence_length":756,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"4348676b06a04292e25f4d78a6d077cc848808845081811362c1b732548117cb","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q5QJE6.json","taxon_id":"9606","uniprot_accession":"Q5QJE6","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/fcf2-pre-rrna-processing-c-terminal-ipr014810.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR014810","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/fcf2-pre-rrna-processing-c-terminal-ipr014810.yaml"}],"pfam_ids":["PF08698"],"protein_name":"Deoxynucleotidyltransferase terminal-interacting protein 2","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MVVTRSGLSRTRLQESSQQKRSAPRRIGTHLESTKESGSDGSTAESQPAEKQHSRSSSRTTGPAEIIVLISDDEASETESHTSGVTSVLEDQEPIVRVTRKRQIVIASTSKSTVRKRQKVAPQHASADEVVVSEAESHVSGVSMVVPSTERSSRNKANSQRDSSQESQSGTVSDAELSCSGISSLEILPRTTARNVKKKLQFPAEKNDTKITPGNKKQIVGMSVCSEDSDATQLSARPLSQRNMPNVSDSETYNSDFDDSSPRNSGKKLTAQNHQNLHIQEEKRANVVSLTEVRKENCKSLDEEDLKITEEKVINEKDSQRSLSEAQDTSLQQSVSQNHSSTPNKKPTFQLSSPDRKALMKSLEHKFAVVNVERWNDKRGGSGKKSDLAQLGGGGGGGDDNEPTGAGISDDKSSQSGVPLECDTKPCKSELSMTQDTTDSPVLLFLSSDESQQSDSSENERDTLCSVENNGQKEASAEDLEDAACDSALFVIDKTPGLSADKNFYLEDKAPSEVAIEEEKEEEEKEEENSEEDSSDSDENKDESSDEEDLLSNTKSKLLKLTSSSIDPGLNIKQLGGLYINFNVDKLQPHKETLTQIKEKKKNELLQKAVITPDFEKKHCVPPYSESKHRLQKQRRKERQKTAGNGWFGMKAPELTDELKNDLRALKMRAGMDPKRFYKKNDRDGFPKYFQVGTIVDNPADFYHSRIPKKQRKKTIVEELLADSEFRRFNRRKYSEIMAEKAANAEGKKFKKKKKFRN","sequence_length":758,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"94a18553c3514002366e2e33c94ad2fe89168cf49a084024698caaeaf1471260","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q8R2M2.json","taxon_id":"10090","uniprot_accession":"Q8R2M2","uniprot_release":"2026_03"}],"pfam_id":"PF08698","short_name":"Fcf2","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}