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This new glycosyltransferase fold has been named GT-D [[cite:PUB00081880]].","domain_architectures":21,"interpro_id":"IPR014869","known_evidence_count":null,"matches":343,"name":"Glycosyltransferase GT-D fold","partial_evidence_count":null,"pfam_id":"PF08759","proteins":343,"proteomes":310,"short_name":"GT-D","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08759","structures":4,"taxa":665,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF08759.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":198,"domain_architectures":21,"matches":343,"proteins":343,"proteomes":310,"structures":4,"taxa":665},"curation_status":"SEEDED","description":"This domain is found at the C terminus of proteins such as the probable glycosyltransferase Gly ([swissprot:Q9AEU2]) that also contain the glycosyl transferase domain at the N terminus. It is also found N-terminal in numerous putative glycosyltransferases such as GalT1. GalT1 has been shown to catalyse the third step of Fap1 glycosylation [[cite:PUB00081880]]. This domain is structurally distinct from all known GT folds of glycosyltransferases and contains a metal binding site. This new glycosyltransferase fold has been named GT-D [[cite:PUB00081880]].","id":"Pfam:PF08759","interpro_id":"InterPro:IPR014869","name":"Glycosyltransferase GT-D fold","pfam_id":"PF08759","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"GT-D","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08759"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF08759.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"e2fa798535fc60ed1c7236aea7da60bee8d891a97bc34093795ae0d589dca46b"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/gt-d-pf08759.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF08759","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/gt-d-pf08759.yaml"}],"pfam_ids":["PF01501","PF08759","PF30761"],"protein_name":"Glycosyltransferase GlyD","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MNKTIVLAGDRNYTRQLETTIKSILYHNRDVKIYILNQDIMPDWFRKPRKIARMLGSEIIDVKLPEQTVFQDWEKQDHISSITYARYFIADYIQEDKVLYLDSDLIVNTSLEKLFSICLEEKSLAAVKDTDGITFNAGVLLINNKKWRQEKLKERLIEQSIVTMKEVEEGRFEHFNGDQTIFNQVLQDDWLELGRAYNLQVGHDIVALYNNWQEHLAFNDKPVVIHFTTYRKPWTTLTANRYRDLWWEFHDLEWSQILQHHMGEFELISPLDKEFSCLTLTNSQDLEGIEELVTALPEVVFHIAAWTDMGDKLKKLAVYNNVRLHPQIVPPVLDKLKKSTNLYLDINHGSADENFLKSLQEQEKTLLAFQSTQHGELGQIVFENGKVSFMIDTIKDFKKNGHLTCFRQLPSLTCLTFTASQYIEQLDYLAGQLPNVVFQIAAWTAMGPKLYDLSNRYPNIQLYPAISRDKLDELKEKMDAYLDINLLTSTSDIVAEMAHLSKPILAFYKSQNGNNGQRLYSSEHPERMLADLQKLITKDMLEKPLDIIQVKGIDETLDYIIEHNSSLVRFGDGEINMLAGHSIPYQDYDEELVSIMRDIIGQESREDLVVCLPDAFTDRFRFTSWAIPFWKDHMDHYMDFYRELCSDSWYGSTFVSRPYIDFEDKSQAKAQFEKLKSIWENRDLLIVEGATSRSGVGNDLFDEANSIKRIICPSHSAFSRVHELEQEIEKYAGGRLILCMLGPTAKVLSYNLCQMGYQVLDVGHIDSEYEWMKMGAKTKVKFSHKHTAEHNFDQDIEFIDDETYNSQIVARILN","sequence_length":814,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"5f6749d917e518f0d3cd9c9c454283964b14edafb53c0f27bb22924721fed6e7","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/A0A0H2URB1.json","taxon_id":"170187","uniprot_accession":"A0A0H2URB1","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Streptococcus gordonii","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/gt-d-pf08759.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF08759","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/gt-d-pf08759.yaml"}],"pfam_ids":["PF01501","PF08759","PF30761"],"protein_name":"Probable glycosyl transferase Gly","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MDKLENKSMANYDEYRAVVICASFSDCNQVLTTIKSIVCHNRFIKFYVINNDFPTEWFVSMQKKLAKLDCPIVNARVDASLVSNFKTDISYTVFLRYFVADFVEEEQALYLDCDIVVTRDLSEIFAVDLGSHPLVAVRDLGGEVYFGEQIFNSGVLLINVNYWRENDIAGQLIEMTDNLHDKVTQDDQSILNMFFENRWVELPFPYNCITLHTTFSDYEPEKGLYPPVIHYLPERKPWKEYTQSIYREVWWFYQGLDWSDIQEPVGALTQKMVEGEDDSSLSCLVYTYSCDLLHINYLIQALPSCHFYIAAPVVVAEPITRLLQYPNVSVSSDIAGIPALLESLEAKSQLLLDINAGDEVGDIIARFKSSGKPVFAFDSTVHGQQGQEVFPADNPEVMVQAIEKLGLAEPEERQISVLSIDQSLDYLLEKGASVVRFGDGEMDLIAGRGIPYQEYDPELSARLREMMAMESNERLMICLSDVFTGLERYSIDAQNFWKAHLQHHLADYLEICRAPWYGSTFISRPYIDLEDKTPSAGYFAKLKQLWQDKDLLIVEGLTSRSGVGNDLFDGARSIKRIICPSRNAYSKLEAIKQAVREHADNRLILTMLGPTAKVLVYDLVQEGYRALDIGHIDSEYEWFQMGASHKIKLSHKHTAEHNFDQDIEYRDDQAYDSQIVANLAQE","sequence_length":682,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"92353736c617c9ea1cb1bcd3059c0d88bf52a526f01d664a37040649b9201b81","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q9AEU2.json","taxon_id":"1302","uniprot_accession":"Q9AEU2","uniprot_release":"2026_03"}],"pfam_id":"PF08759","short_name":"GT-D","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}