{"cross_mech":[],"family":{"alphafold_models":256,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This domain is predominantly found in the structural protein coronin, and is duplicated in some sequences. It appears to have the function of stabilising the topology of short coiled-coils in proteins [[cite:PUB00035387]].","domain_architectures":8,"interpro_id":"IPR015049","known_evidence_count":null,"matches":291,"name":"Trimerisation motif","partial_evidence_count":null,"pfam_id":"PF08954","proteins":291,"proteomes":182,"short_name":"Trimer_CC","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08954","structures":1,"taxa":613,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF08954.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":256,"domain_architectures":8,"matches":291,"proteins":291,"proteomes":182,"structures":1,"taxa":613},"curation_status":"SEEDED","description":"This domain is predominantly found in the structural protein coronin, and is duplicated in some sequences. It appears to have the function of stabilising the topology of short coiled-coils in proteins [[cite:PUB00035387]].","id":"Pfam:PF08954","interpro_id":"InterPro:IPR015049","name":"Trimerisation motif","pfam_id":"PF08954","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"Trimer_CC","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08954"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF08954.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"7c6f6808a4f4357796522797c355866d656f70bee5d1a599d115f841bee3ad22"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/trimer-cc-pf08954.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF08954","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/trimer-cc-pf08954.yaml"}],"pfam_ids":["PF00400","PF08953","PF08954","PF16300"],"protein_name":"Coronin-1A","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSRQVVRSSKFRHVFGQPAKADQCYEDVRVSQTTWDSGFCAVNPKFMALICEASGGGAFLVLPLGKTGRVDKNVPLVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSRDGALICTSCRDKRVRVIEPRKGTVVAEKDRPHEGTRPVHAVFVSEGKILTTGFSRMSERQVALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEAPFLHYLSMFSSKESQRGMGYMPKRGLEVNKCEIARFYKLHERKCEPIAMTVPRKSDLFQEDLYPPTAGPDPALTAEEWLGGRDAGPLLISLKDGYVPPKSRELRVNRGLDSARRRATPEPSGTPSSDTVSRLEEDVRNLNAIVQKLQERLDRLEETVQAK","sequence_length":461,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"07e30966e76bae97e9f7ec07e167a2e5afbe864d54d5254f13d7faa49eb437a8","sequence_version":5,"source_url":"https://rest.uniprot.org/uniprotkb/O89053.json","taxon_id":"10090","uniprot_accession":"O89053","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/trimer-cc-pf08954.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF08954","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/trimer-cc-pf08954.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/repeat/pfam/duf1899-pf08953.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF08953","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/repeat/pfam/duf1899-pf08953.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/repeat/pfam/wd40-4-pf16300.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF16300","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/repeat/pfam/wd40-4-pf16300.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:P31146","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF00400","PF08953","PF08954","PF16300"],"protein_name":"Coronin-1A","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"824168a353a6fa9e4a03407d5caa7399fa2a6f8efeedcf13c93293e102fcf95c","sequence_version":4,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MSRQVVRSSKFRHVFGQPAKADQCYEDVRVSQTTWDSGFCAVNPKFVALICEASGGGAFLVLPLGKTGRVDKNAPTVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLMLPLREPVVTLEGHTKRVGIVAWHTTAQNVLLSAGCDNVIMVWDVGTGAAMLTLGPEVHPDTIYSVDWSRDGGLICTSCRDKRVRIIEPRKGTVVAEKDRPHEGTRPVRAVFVSEGKILTTGFSRMSERQVALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEAPFLHYLSMFSSKESQRGMGYMPKRGLEVNKCEIARFYKLHERRCEPIAMTVPRKSDLFQEDLYPPTAGPDPALTAEEWLGGRDAGPLLISLKDGYVPPKSRELRVNRGLDTGRRRAAPEASGTPSSDAVSRLEEEMRKLQATVQELQKRLDRLEETVQAK","sequence_length":461,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"824168a353a6fa9e4a03407d5caa7399fa2a6f8efeedcf13c93293e102fcf95c","sequence_version":4,"source_url":"https://rest.uniprot.org/uniprotkb/P31146.json","taxon_id":"9606","uniprot_accession":"P31146","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Bos taurus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/trimer-cc-pf08954.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF08954","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/trimer-cc-pf08954.yaml"}],"pfam_ids":["PF00400","PF08953","PF08954","PF16300"],"protein_name":"Coronin-1A","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSRQVVRSSKFRHVFGQPAKADQCYEDVRVSQNTWDSGFCAVNPKFVALICEASGGGAFLVLPLGKTGRVDKNVPMVCGHTAPVLDIAWCPHNDNVIASGSEDCSVMVWEIPDGGLTLPLREPVVTLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGVAVLTLGSDVHPDTIYSVDWSRDGALICTSCRDKRVRIIEPRKGTIVAEKDRPHEGTRPVRAVFVSDGKILTTGFSRMSERQVALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEAPFLHYLSMFSSKESQRGMGYMPKRGLEVNKCEIARFYKLHERKCEPIAMTVPRKSDLFQEDLYPPTAGPDAALTAEEWLGGRDAGPLLISLKDGYVPPKSRELRVNRGLDTGRKRTTPEASGAPSSDAISRLEEEMRKLQATVQELQKRLDRLEETVQAK","sequence_length":461,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"63994e54f7872d81aff92cfd2fe2e9bfced1fd462088f81768a95b48e8a4c8ff","sequence_version":3,"source_url":"https://rest.uniprot.org/uniprotkb/Q92176.json","taxon_id":"9913","uniprot_accession":"Q92176","uniprot_release":"2026_03"}],"pfam_id":"PF08954","short_name":"Trimer_CC","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}