{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF09186","protein_label":"IMPACT family member YvyE","reviewed":true,"short_name":"DUF1949","source_category":"function/protein_family/ncbifam","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/protein_family/ncbifam/yigz-family-protein-tigr00257.yaml","source_record_id":"NCBIfam:TIGR00257","source_record_label":"YigZ family protein","source_section":"canonical_examples","taxon_id":"NCBITaxon:224308","taxon_label":"Bacillus subtilis (strain 168)","uniprot_accession":"P32437","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF09186","protein_label":"IMPACT family member YvyE","reviewed":true,"short_name":"DUF1949","source_category":"sequence/conservation/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/conservation/interpro/uncharacterised-protein-family-upf0029-impact-conserved-site-ipr020569.yaml","source_record_id":"InterPro:IPR020569","source_record_label":"Uncharacterised protein family UPF0029, Impact, conserved site","source_section":"canonical_examples","taxon_id":"NCBITaxon:224308","taxon_label":"Bacillus subtilis (strain 168)","uniprot_accession":"P32437","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF09186","protein_label":"IMPACT family member YvyE","reviewed":true,"short_name":"DUF1949","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/impact-n-terminal-ipr001498.yaml","source_record_id":"InterPro:IPR001498","source_record_label":"Impact, N-terminal","source_section":"canonical_examples","taxon_id":"NCBITaxon:224308","taxon_label":"Bacillus subtilis (strain 168)","uniprot_accession":"P32437","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF09186","protein_label":"IMPACT family member YvyE","reviewed":true,"short_name":"DUF1949","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/uncharacterised-domain-upf0029-impact-c-terminal-ipr015269.yaml","source_record_id":"InterPro:IPR015269","source_record_label":"Uncharacterised domain UPF0029, Impact, C-terminal","source_section":"canonical_examples","taxon_id":"NCBITaxon:224308","taxon_label":"Bacillus subtilis (strain 168)","uniprot_accession":"P32437","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF09186","protein_label":"","reviewed":null,"short_name":"DUF1949","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/uncharacterised-domain-upf0029-impact-c-terminal-ipr015269.yaml","source_record_id":"InterPro:IPR015269","source_record_label":"Uncharacterised domain UPF0029, Impact, C-terminal","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF09186","protein_label":"IMPACT family member YigZ","reviewed":true,"short_name":"DUF1949","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf1949-pf09186.yaml","source_record_id":"Pfam:PF09186","source_record_label":"Domain of unknown function (DUF1949)","source_section":"canonical_examples","taxon_id":"NCBITaxon:83333","taxon_label":"Escherichia coli (strain K12)","uniprot_accession":"P27862","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF09186","protein_label":"IMPACT family member YvyE","reviewed":true,"short_name":"DUF1949","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf1949-pf09186.yaml","source_record_id":"Pfam:PF09186","source_record_label":"Domain of unknown function (DUF1949)","source_section":"canonical_examples","taxon_id":"NCBITaxon:224308","taxon_label":"Bacillus subtilis (strain 168)","uniprot_accession":"P32437","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF09186","protein_label":"IMPACT family member HI_0722","reviewed":true,"short_name":"DUF1949","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf1949-pf09186.yaml","source_record_id":"Pfam:PF09186","source_record_label":"Domain of unknown function (DUF1949)","source_section":"canonical_examples","taxon_id":"NCBITaxon:71421","taxon_label":"Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)","uniprot_accession":"P44842","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF09186","protein_label":"","reviewed":null,"short_name":"DUF1949","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf1949-pf09186.yaml","source_record_id":"Pfam:PF09186","source_record_label":"Domain of unknown function (DUF1949)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF09186","protein_label":"IMPACT family member YvyE","reviewed":true,"short_name":"DUF1949","source_category":"sequence/homologous_superfamily/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/homologous_superfamily/interpro/impact-n-terminal-domain-superfamily-ipr036956.yaml","source_record_id":"InterPro:IPR036956","source_record_label":"Impact, N-terminal domain superfamily","source_section":"canonical_examples","taxon_id":"NCBITaxon:224308","taxon_label":"Bacillus subtilis (strain 168)","uniprot_accession":"P32437","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF09186","protein_label":"IMPACT family member YvyE","reviewed":true,"short_name":"DUF1949","source_category":"structure/homologous_superfamily/cath","source_mech":"ProteinTraitsMech","source_path":"data/traits/structure/homologous_superfamily/cath/impact-n-terminal-domain-3-30-230-30.yaml","source_record_id":"CATH:3.30.230.30","source_record_label":"Impact, N-terminal domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:224308","taxon_label":"Bacillus subtilis (strain 168)","uniprot_accession":"P32437","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":5636,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function","domain_of_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":3,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":7},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"Members of this family pertain to a set of functionally uncharacterised hypothetical bacterial proteins. They adopt a ferredoxin-like fold, with a beta-alpha-beta-beta-alpha-beta arrangement [[cite:PUB00032088]].","domain_architectures":8,"interpro_id":"IPR015269","known_evidence_count":null,"matches":9056,"name":"Domain of unknown function (DUF1949)","partial_evidence_count":null,"pfam_id":"PF09186","proteins":9056,"proteomes":9028,"short_name":"DUF1949","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09186","structures":2,"taxa":12454,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF09186.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":5636,"domain_architectures":8,"matches":9056,"proteins":9056,"proteomes":9028,"structures":2,"taxa":12454},"curation_status":"SEEDED","description":"Members of this family pertain to a set of functionally uncharacterised hypothetical bacterial proteins. They adopt a ferredoxin-like fold, with a beta-alpha-beta-beta-alpha-beta arrangement [[cite:PUB00032088]].","id":"Pfam:PF09186","interpro_id":"InterPro:IPR015269","name":"Domain of unknown function (DUF1949)","pfam_id":"PF09186","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF1949","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09186"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF09186.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"aafc7b37d732e322c410bcc44444d1a8631652a6496ea1f46129dbfa42cca946"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Escherichia coli (strain K12)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf1949-pf09186.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF09186","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf1949-pf09186.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:P27862","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF01205","PF09186"],"protein_name":"IMPACT family member YigZ","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"8f88ddf5009127358f095276fd52e5125d5941c3f3115137d99179c5fc475615","sequence_version":2,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MESWLIPAAPVTVVEEIKKSRFITMLAHTDGVEAAKAFVESVRAEHPDARHHCVAWVAGAPDDSQQLGFSDDGEPAGTAGKPMLAQLMGSGVGEITAVVVRYYGGILLGTGGLVKAYGGGVNQALRQLTTQRKTPLTEYTLQCEYHQLTGIEALLGQCDGKIINSDYQAFVLLRVALPAAKVAEFSAKLADFSRGSLQLLAIEE","sequence_length":204,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"8f88ddf5009127358f095276fd52e5125d5941c3f3115137d99179c5fc475615","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/P27862.json","taxon_id":"83333","uniprot_accession":"P27862","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Bacillus subtilis (strain 168)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/protein_family/ncbifam/yigz-family-protein-tigr00257.yaml","qualification_status":"NOT_ASSESSED","record_id":"NCBIfam:TIGR00257","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/protein_family/ncbifam/yigz-family-protein-tigr00257.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/conservation/interpro/uncharacterised-protein-family-upf0029-impact-conserved-site-ipr020569.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR020569","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/conservation/interpro/uncharacterised-protein-family-upf0029-impact-conserved-site-ipr020569.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/impact-n-terminal-ipr001498.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR001498","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/impact-n-terminal-ipr001498.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/uncharacterised-domain-upf0029-impact-c-terminal-ipr015269.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR015269","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/uncharacterised-domain-upf0029-impact-c-terminal-ipr015269.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf1949-pf09186.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF09186","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf1949-pf09186.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/impact-n-terminal-domain-superfamily-ipr036956.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR036956","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/impact-n-terminal-domain-superfamily-ipr036956.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/impact-n-terminal-domain-3-30-230-30.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:3.30.230.30","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/impact-n-terminal-domain-3-30-230-30.yaml"}],"pfam_ids":["PF01205","PF09186"],"protein_name":"IMPACT family member YvyE","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MLHSYFTVKEAGEHEIVIEKSRFICHLSRVSTEQEAQEFIQKIKKQHWNATHNCSAYVIGENDHIQKANDDGEPSGTAGVPMLEVLKKRRLKDTCAVVTRYFGGIKLGAGGLIRAYGKSVSEGLNHIGVVERKLMRIMHTSADYTWLGKIENELRESQFLLKEIHYSENVEFETYVEEKETNAFSEWMTELTNGKSDIKEGELTYLEKAVNHIKETE","sequence_length":217,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"166c7209cad521599e460171ec7b4e06683d3203943a90c9c0e41ab0ad165823","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/P32437.json","taxon_id":"224308","uniprot_accession":"P32437","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf1949-pf09186.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF09186","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf1949-pf09186.yaml"}],"pfam_ids":["PF01205","PF09186"],"protein_name":"IMPACT family member HI_0722","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAEYLVPKSAVVFEEEIKKSRFITYLQHTEGLEDARAFWAKIKQEHPNARHHCWAAVAGKPTDSLQLGFSDDGEPAGTAGKPMLSALQGSQLGEISAVVVRYYGGILLGTGGLVRAYGNGVQQALKLIESEIKVERTLFKLDCDYGQLRLVQQLCEKYQVEILSQGFQANIHLILGISEKTIEAFSSELTEKSSGRLVIQLLEIGE","sequence_length":206,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"2694b6397ada90d5744c6df2325ff211ac21d187f56997475873f3e2cac29794","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P44842.json","taxon_id":"71421","uniprot_accession":"P44842","uniprot_release":"2026_03"}],"pfam_id":"PF09186","short_name":"DUF1949","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
