{"cross_mech":[],"family":{"alphafold_models":76,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This OB-fold domain folds into a five-stranded beta-barrel [[cite:PUB00018994]]. Members of this family are found in various staphylococcal toxins described as staphylococcal superantigen-like (SSL) proteins that are related to the staphylococcal enterotoxins (SEs) or superantigens. These SSL proteins of which 11 have so far been characterised have a typical SE tertiary structure consisting of a distinct oligonucleotide/oligosaccharide binding (OB-fold), this domain, linked to a beta-grasp domain, family Stap_Strp_tox_C, [pfam:PF02876]. SSLs do not bind to T-cell receptors or major histocompatibility complex class II molecules and do not stimulate T cells. SSLs target components of innate immunity, such as complement, Fc receptors, and myeloid cells 2,3,4,5,6,7,8]. SSL protein 7 (SSL7) is the best characterised of the SSLs and binds complement factor C5 and IgA with high affinity and inhibits the end stage of complement activation and IgA binding to FcalphaR [[cite:PUB00065773]].","domain_architectures":2,"interpro_id":"IPR015282","known_evidence_count":null,"matches":88,"name":"Staphylococcal superantigen-like OB-fold domain","partial_evidence_count":null,"pfam_id":"PF09199","proteins":88,"proteomes":15,"short_name":"SSL_OB","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09199","structures":31,"taxa":31,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF09199.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":76,"domain_architectures":2,"matches":88,"proteins":88,"proteomes":15,"structures":31,"taxa":31},"curation_status":"SEEDED","description":"This OB-fold domain folds into a five-stranded beta-barrel [[cite:PUB00018994]]. Members of this family are found in various staphylococcal toxins described as staphylococcal superantigen-like (SSL) proteins that are related to the staphylococcal enterotoxins (SEs) or superantigens. These SSL proteins of which 11 have so far been characterised have a typical SE tertiary structure consisting of a distinct oligonucleotide/oligosaccharide binding (OB-fold), this domain, linked to a beta-grasp domain, family Stap_Strp_tox_C, [pfam:PF02876]. SSLs do not bind to T-cell receptors or major histocompatibility complex class II molecules and do not stimulate T cells. SSLs target components of innate immunity, such as complement, Fc receptors, and myeloid cells 2,3,4,5,6,7,8]. SSL protein 7 (SSL7) is the best characterised of the SSLs and binds complement factor C5 and IgA with high affinity and inhibits the end stage of complement activation and IgA binding to FcalphaR [[cite:PUB00065773]].","id":"Pfam:PF09199","interpro_id":"InterPro:IPR015282","name":"Staphylococcal superantigen-like OB-fold domain","pfam_id":"PF09199","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"SSL_OB","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09199"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF09199.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"2a4636a37118cb4b82f2936b53cab508462df3792cda05f8a1e763859f626a0c"}},"protein_examples":{"candidate_count":0,"discovery_scanned":true,"example_count":0,"examples":[],"pfam_id":"PF09199","short_name":"SSL_OB","status":"NO_SIBLING_CANDIDATE","unresolved":[]}}