{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF09323","protein_label":"UPF0703 protein YcgQ","reviewed":true,"short_name":"DUF1980","source_category":"function/protein_family/ncbifam","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/protein_family/ncbifam/tigr03943-family-putative-permease-subunit-tigr03943.yaml","source_record_id":"NCBIfam:TIGR03943","source_record_label":"TIGR03943 family putative permease subunit","source_section":"canonical_examples","taxon_id":"NCBITaxon:224308","taxon_label":"Bacillus subtilis (strain 168)","uniprot_accession":"P94394","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF09323","protein_label":"UPF0703 protein YcgQ","reviewed":true,"short_name":"DUF1980","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/duf1980-c-terminal-domain-ipr048447.yaml","source_record_id":"InterPro:IPR048447","source_record_label":"DUF1980, C-terminal domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:224308","taxon_label":"Bacillus subtilis (strain 168)","uniprot_accession":"P94394","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF09323","protein_label":"UPF0703 protein YcgQ","reviewed":true,"short_name":"DUF1980","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/duf1980-n-terminal-domain-ipr048493.yaml","source_record_id":"InterPro:IPR048493","source_record_label":"DUF1980, N-terminal domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:224308","taxon_label":"Bacillus subtilis (strain 168)","uniprot_accession":"P94394","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF09323","protein_label":"","reviewed":null,"short_name":"DUF1980","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/duf1980-n-terminal-domain-ipr048493.yaml","source_record_id":"InterPro:IPR048493","source_record_label":"DUF1980, N-terminal domain","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF09323","protein_label":"UPF0703 protein YcgQ","reviewed":true,"short_name":"DUF1980","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf1980-c-pf21537.yaml","source_record_id":"Pfam:PF21537","source_record_label":"DUF1980 C-terminal domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:224308","taxon_label":"Bacillus subtilis (strain 168)","uniprot_accession":"P94394","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF09323","protein_label":"Putative two-component membrane permease complex subunit SMU_746c","reviewed":true,"short_name":"DUF1980","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf1980-c-pf21537.yaml","source_record_id":"Pfam:PF21537","source_record_label":"DUF1980 C-terminal domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:210007","taxon_label":"Streptococcus mutans serotype c (strain ATCC 700610 / UA159)","uniprot_accession":"Q8DUY4","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF09323","protein_label":"UPF0703 protein YcgQ","reviewed":true,"short_name":"DUF1980","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf1980-pf09323.yaml","source_record_id":"Pfam:PF09323","source_record_label":"DUF1980 N-terminal domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:224308","taxon_label":"Bacillus subtilis (strain 168)","uniprot_accession":"P94394","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF09323","protein_label":"Putative two-component membrane permease complex subunit SMU_746c","reviewed":true,"short_name":"DUF1980","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf1980-pf09323.yaml","source_record_id":"Pfam:PF09323","source_record_label":"DUF1980 N-terminal domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:210007","taxon_label":"Streptococcus mutans serotype c (strain ATCC 700610 / UA159)","uniprot_accession":"Q8DUY4","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF09323","protein_label":"","reviewed":null,"short_name":"DUF1980","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf1980-pf09323.yaml","source_record_id":"Pfam:PF09323","source_record_label":"DUF1980 N-terminal domain","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"KNOWN_HISTORICAL_DUF"}],"family":{"alphafold_models":1219,"candidate_reasons":["short_name_matches_duf"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":2,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":5},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"Members of this family are found in a set of prokaryotic hypothetical proteins. Their exact function, has not, as yet, been defined. This entry represents the N-terminal 3-transmembrane helical domain.","domain_architectures":5,"interpro_id":"IPR048493","known_evidence_count":null,"matches":1979,"name":"DUF1980 N-terminal domain","partial_evidence_count":null,"pfam_id":"PF09323","proteins":1967,"proteomes":1678,"short_name":"DUF1980","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09323","structures":0,"taxa":2503,"unknown_status":"KNOWN_HISTORICAL_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF09323.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1219,"domain_architectures":5,"matches":1979,"proteins":1967,"proteomes":1678,"structures":0,"taxa":2503},"curation_status":"SEEDED","description":"Members of this family are found in a set of prokaryotic hypothetical proteins. Their exact function, has not, as yet, been defined. This entry represents the N-terminal 3-transmembrane helical domain.","id":"Pfam:PF09323","interpro_id":"InterPro:IPR048493","name":"DUF1980 N-terminal domain","pfam_id":"PF09323","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"KNOWN_HISTORICAL_DUF","short_name":"DUF1980","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09323"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF09323.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"388b13f68c4aa8be672ac4b4ce7de338e2a46cae6d5c0a8f8d6ad5626652825d"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Bacillus subtilis (strain 168)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/protein_family/ncbifam/tigr03943-family-putative-permease-subunit-tigr03943.yaml","qualification_status":"NOT_ASSESSED","record_id":"NCBIfam:TIGR03943","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/protein_family/ncbifam/tigr03943-family-putative-permease-subunit-tigr03943.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/duf1980-c-terminal-domain-ipr048447.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR048447","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/duf1980-c-terminal-domain-ipr048447.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/duf1980-n-terminal-domain-ipr048493.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR048493","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/duf1980-n-terminal-domain-ipr048493.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf1980-c-pf21537.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF21537","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf1980-c-pf21537.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf1980-pf09323.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF09323","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf1980-pf09323.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:P94394","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF09323","PF21537"],"protein_name":"UPF0703 protein YcgQ","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"e6b3b2bfc110e7b933f720845ad67f3f834a099d19baf0cd9a5da257a7ce6af6","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MFRLLVLMGFTFFFYHLHASGNLTKYINMKYAYLSFIAIFLLAILTAVQAYLFIKSPEKSGHHHDHDCGCGHDHEHDHEQNKPFYQRYLIYVVFLFPLVSGIFFPIATLDSSIVKTKGFSFKAMESGDHYSQTQYLRPDASLYYAQDSYDKQMKQLFNKYSSKKEISLTDDDFLKGMETIYNYPGEFLGRTIEFHGFAYKGNAINKNQLFVLRFGIIHCIADSGVYGMLVEFPKDMDIKDDEWIHIKGTLASEYYQPFKSTLPVVKVTDWNTIKKPDDPYVYRGF","sequence_length":285,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"e6b3b2bfc110e7b933f720845ad67f3f834a099d19baf0cd9a5da257a7ce6af6","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P94394.json","taxon_id":"224308","uniprot_accession":"P94394","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Streptococcus mutans serotype c (strain ATCC 700610 / UA159)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf1980-c-pf21537.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF21537","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf1980-c-pf21537.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf1980-pf09323.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF09323","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf1980-pf09323.yaml"}],"pfam_ids":["PF09323","PF21537"],"protein_name":"Putative two-component membrane permease complex subunit SMU_746c","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MIRFLILAGYFELGMYLQLSGKLDRYINSHYSYLAYISMALSFILALVQLTIWMKRLKMHSHLSGKAAKFFSPIILAIPVFIGLLVPTVPLDSTTVSAKGYHFPLAAGSTTSGTSSDGTRVQYLKPDTSLYFTKSAYQKEMRATLKKYKGSGKLQITTQNYMEVMEIIYLFPDEFKNRQIEYVGFIYNDPKDKNSQFLFRFGIIHCIADSGVYGLLTTGGQTHYQNNTWVTVSGKLAIEYNQNLKQTLPVLHISQSSQTMQPKNPYVYRVF","sequence_length":271,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"606eb8d4557e751c8debadae7f71ff5cfca2e53ff5fcce41d3ab85d098f2a7ad","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q8DUY4.json","taxon_id":"210007","uniprot_accession":"Q8DUY4","uniprot_release":"2026_03"}],"pfam_id":"PF09323","short_name":"DUF1980","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}