{"cross_mech":[],"family":{"alphafold_models":1000,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This entry represents a HDS (homology downstream of Sec7) domain found towards the C-terminal of guanine nucleotide exchange factors involved Golgi transport, such as budding yeast protein Sec7, protein Mon2 and BIG1-like proteins [[cite:PUB00101185],[cite:PUB00101184]]. Sec7 is involved in the secretory pathway as a protein binding scaffold for the COPII-COPI protein switch for maturation of the VTC intermediate compartments for Golgi compartment biogenesis [[cite:PUB00076747]]. 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Sec7 is involved in the secretory pathway as a protein binding scaffold for the COPII-COPI protein switch for maturation of the VTC intermediate compartments for Golgi compartment biogenesis [[cite:PUB00076747]]. Sec7 has four HDS1-4 domains, which act to integrate the signals from several small GTPases, including Arf1 itself, to switch Sec7 from a strongly autoinhibited to a strongly auto activated form [[cite:PUB00101184]].","id":"Pfam:PF09324","interpro_id":"InterPro:IPR015403","name":"Mon2/Sec7/BIG1-like, 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A-inhibited guanine nucleotide-exchange protein 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sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/big2-c-pf20252.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF20252","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/big2-c-pf20252.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/repeat/pfam/dcb-pf16213.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF16213","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/repeat/pfam/dcb-pf16213.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/repeat/pfam/sec7-like-hus-pf12783.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF12783","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/repeat/pfam/sec7-like-hus-pf12783.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/sec7-like-hds-pf09324.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF09324","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/sec7-like-hds-pf09324.yaml"}],"pfam_ids":["PF01369","PF09324","PF12783","PF16213","PF20252"],"protein_name":"Brefeldin A-inhibited guanine nucleotide-exchange protein 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