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Nudel, pipe and windbeutel together trigger the protease cascade within the extraembryonic perivitelline compartment which induces dorsoventral polarity of the Drosophila embryo [[cite:PUB00054161]].","domain_architectures":64,"interpro_id":"IPR015420","known_evidence_count":null,"matches":362,"name":"Nudel, serine protease domain","partial_evidence_count":null,"pfam_id":"PF09342","proteins":358,"proteomes":298,"short_name":"Nudel","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09342","structures":0,"taxa":1160,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF09342.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":91,"domain_architectures":64,"matches":362,"proteins":358,"proteomes":298,"structures":0,"taxa":1160},"curation_status":"SEEDED","description":"This domain is found in Nudel from Drosophila melanogaster and related proteins. Nudel is involved in defining embryonic dorsoventral polarity. Three proteiases ndl, gd and snk process easter to create active easter. Active easter defines cell identities along the dorsal-ventral continuum by activating the spz ligand for the Tl receptor in the ventral region of the embryo. Nudel, pipe and windbeutel together trigger the protease cascade within the extraembryonic perivitelline compartment which induces dorsoventral polarity of the Drosophila embryo [[cite:PUB00054161]].","id":"Pfam:PF09342","interpro_id":"InterPro:IPR015420","name":"Nudel, serine protease domain","pfam_id":"PF09342","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"Nudel","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09342"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF09342.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"0f0d37a32bd05cbb16f0c21e42444addd23fe8cae18f9f33fd1c9238eabc820b"}},"protein_examples":{"candidate_count":1,"discovery_scanned":true,"example_count":1,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Drosophila melanogaster","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/nudel-pf09342.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF09342","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/nudel-pf09342.yaml"}],"pfam_ids":["PF00057","PF00089","PF09342"],"protein_name":"Serine protease ndl","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MNYNMDEMEATRLLRHPRRWWSIGFGKRIVAISILVIIVLLFSLVYHGLVVEKIDQVQQIAALNARHQVLFNQPFEEDQSALIVSPQTLHFKLLDEDMNKDMEDSKNRRRKHMRQMLVKFRLNKKHRMRRDLHGLDLLDPVRMEANMQHLYTKLRSKRAREALSQLEHEFVRCKKHTPQDCMSAFLRMYKMAKEVTEKMEKMKAIMREQQPKLESSSMESHEQKGTFSPADLIQVTTAEATTVAVHATEKPARTKIKPSRISWIIDGHDHDESPVYTDGAPKKETTKAPWNTTQLVEITTTKIDATATERTTVESTTEKISWILDHFDKPQEILRTTEGPGQRIIRNVTTTSASSEPIVDTENTNSDHVPTTENGLVFNITTDGPVETTKSTAQRKLSFDWILDGEENVEPEVKSTNTTTTTAATTTTGATSETIIVTTELPKITFDWIIDGREVVEPQETTTEVTGTTERLRKMPFDWIIDGEEVVEPQENVTTTTIATTVAVSTTEINERIHNSTAYPTKPKPVKFDWIIDGGESSGEVSTSSTSQPKLTTREAISNPESPRSSHPLDNPTSIENMLESFEQHEEQKPILRVLNANESSSETVTDGYERQLWLKKFEDQARPNQNELIDTFGTALDAKALDKMGPKINPLNGHTWNAADAQILSLCERVALRMRNKVATMSDGETKEKGETFTASPSVQFTSRAPGGFPVSGETMKASAQFMFNPNFGMPSIPVCFYMTPANFRMPMWSNTPTFMGMQGAHFGGSSNPGAGIFFVPQQFGPSGNFFGGSGGSGAGGQGANIFSKNASPQKPTNGQQQVYCSYMQNQSGQGAGQSQTSSQQQQGGQSAFSNANFKMRHANQTNTANQQGQIIYASYAGLPQQPIQERSRCPEPDQFSCFGQQECIPAARWCDNVVDCSDGSDESACTCADRVDEERLCDGYEDCPMGEDELGCFGCESLAYSCYENPQDFAKRNRSTISMCYSRLERCDGFMNCLNGRDEEQCSMLVTDVADHMSHGASASEGYLYHNYRGDWHPVCNNGEKWAALACQMDENSRMDHSASLNVSFQTLTLPGPFIEPSLHAGVHFAQACHGRNSHDSLVDHVAYVKCPPMQCGLPSKSSMLEHSKRVRRAVSDSKEIVGDGRIVGGSYTSALQWPFVVAIYRNGKFHCGGTIYSDRWIISAAHCVINYGKYFYEVRAGLLRRSSYSPATQIQPVSHVVVHQAYERRSMRNDLSLLRLLNPLQFNRWVKPICLPDKGRTTVGDDWIWGPVEHTLCTVVGWGAIREKGPSSDPMRQVIVPIRKKCTDPEDQASEDICAGDPDGGRDACQGDSGGPLFCRSVSNPDEFYLAGVVSHGNGCARPQEFGVYTRVTLYLDWLEMATTPRLLPKLQPLQLCPGFICVWGGKRCIAKRQRCDRNVDCLGGEDEVGCTYNFLPDMVGGVRQNISTTTESDYHPVKESEEKSKMREVIPIDDEDLKAEQDEEDLLKSTTSLGQTETTQGPMDLSFAEQITSTTSDDLSITDETTSTDFTVSDSATSPSTLLPTTTNPSTWLPSTNIETSTFSFTTTESEASTKQETLPTTVAQTTTIPTSTEDLKKLTDLVTEFIESTTFETTMEVETTTLSLTSTDAPKLVTTEGVKETTTTEDTTTISSIVTLTTTPLATISTTILTTEKHVAVTTLAPTTTTESAKTTTTHSSSTHSEKDQIQIPNKFVCKKMSQIVDIMMRCDRKVDCEDGTDELDCTCKDYLKGSLKGLICDGKADCEDLTDEQNCVECQSNEFRCPLSKTCLPLSSRCDNKVDCKFKEDEKDCFALTNGHDVHFDVHQQPKFSSTGIFSRNGHGVWRVVCAHETGYHEHQAKTADAVCALLGFNGAHYFNSSEFVTQHEMQPITPELKGGRNRMSAQIHSMVGDNVQFTENEVIIPELGHPSASRPEKDRLLPRKCVGIYVECNPYSNKTTPLKTFSAGQVVKEKPIEQVPVLSPTIETHNTPNVHFKPQIPAMVVNKKDEILDRLDKLIKSKKNKTILVNEQLHEAIEELHWPWLADVYMNGDLWCIGVLIDKHWVMVHESCLSGIDLETHYVSVLLGGGKTKRSAHRSNHEQIRRVDCFEGVPKSNVLLLHLERPVRFTHHVLPTFLPDSSHQNQSHARQCISVLHDDATGRIKTVAITRIHNATNCDSCYKLQEKQPPANLMRLLNVSAEDMASISEEVELINGVAPTELPAITKFTTCNQFGLKNVSDAHHNPSDQGVLVCRDSHTGWFPTALFNYNNSDCQSFKQPFGIRTLELVYKSLQDIIDKPSCKMLLPAPDCSTHRCPLGTCLPQAAMCNGRSDCHDGSDEEETKCRQQKQQCAPGEMKCRTSFKCVPKSKFCDHVPDCEDMTDEPTICSCFTYLQATDPSKICDGKRNCWDKSDESSVLCNCTADHFQCSSSPEDCIPRDFVCDKEKDCPNGEDERYCFGIEHPLHLQKKDFWTNSQHTQPEIAPQYGQVIEQTYGIWHTKCFPKSKPPQVDEVREICKKLGYNPYRQPSYRLIDDEENKPVHTYELADRQGRSFSNESLMGKYRDSTKALIISKFSPLQLNERLTLFLKSSRPIAELVRWNATDSSMCYRLEIRCA","sequence_length":2616,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"56d95cbe80411856d7e894061b9f86f0bb7a78c5533d6ecebccc2702f6c95fd8","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/P98159.json","taxon_id":"7227","uniprot_accession":"P98159","uniprot_release":"2026_03"}],"pfam_id":"PF09342","short_name":"Nudel","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}