{"cross_mech":[],"family":{"alphafold_models":2089,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"The centromere, essential for faithful chromosome segregation during mitosis, has a network of constitutive centromere-associated (CCAN) proteins associating with it during mitosis. So far in vertebrates at least 15 centromere proteins have been identified, which are divided into several subclasses based on functional and biochemical analyses. These provide a platform for the formation of a functional kinetochore during mitosis. CENP-S is one that does not associate with the CENP-H-containing complex but rather interacts with CENP-X to form a stable assembly of outer kinetochore proteins that functions downstream of other components of the CCAN. This complex may directly allow efficient and stable formation of the outer kinetochore on the CCAN platform.","domain_architectures":30,"interpro_id":"IPR018552","known_evidence_count":null,"matches":2529,"name":"CENP-S associating Centromere protein X","partial_evidence_count":null,"pfam_id":"PF09415","proteins":2465,"proteomes":2090,"short_name":"CENP-X","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09415","structures":24,"taxa":5655,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF09415.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":2089,"domain_architectures":30,"matches":2529,"proteins":2465,"proteomes":2090,"structures":24,"taxa":5655},"curation_status":"SEEDED","description":"The centromere, essential for faithful chromosome segregation during mitosis, has a network of constitutive centromere-associated (CCAN) proteins associating with it during mitosis. So far in vertebrates at least 15 centromere proteins have been identified, which are divided into several subclasses based on functional and biochemical analyses. These provide a platform for the formation of a functional kinetochore during mitosis. CENP-S is one that does not associate with the CENP-H-containing complex but rather interacts with CENP-X to form a stable assembly of outer kinetochore proteins that functions downstream of other components of the CCAN. This complex may directly allow efficient and stable formation of the outer kinetochore on the CCAN platform.","id":"Pfam:PF09415","interpro_id":"InterPro:IPR018552","name":"CENP-S associating Centromere protein X","pfam_id":"PF09415","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"CENP-X","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09415"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF09415.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"87b40fb16878fbca3a4859737a792b803487b6c6656d9372ad24fc65a076b757"}},"protein_examples":{"candidate_count":4,"discovery_scanned":true,"example_count":4,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/localization/go/fancm-mhf-complex-go0071821.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0071821","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/localization/go/fancm-mhf-complex-go0071821.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/localization/go/fanconi-anaemia-nuclear-complex-go0043240.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0043240","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/localization/go/fanconi-anaemia-nuclear-complex-go0043240.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/cdd/histone-fold-domain-found-in-centromere-protein-x-cenp-x-and-similar-p-cd22921.yaml","qualification_status":"NOT_ASSESSED","record_id":"CDD:cd22921","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/cdd/histone-fold-domain-found-in-centromere-protein-x-cenp-x-and-similar-p-cd22921.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/cenp-x-pf09415.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF09415","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/cenp-x-pf09415.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/1-20-5-4980-1-20-5-4980.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:1.20.5.4980","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/1-20-5-4980-1-20-5-4980.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/6-10-130-30-6-10-130-30.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:6.10.130.30","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/6-10-130-30-6-10-130-30.yaml"}],"pfam_ids":["PF09415"],"protein_name":"Centromere protein X","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MEGAGAGSGFRKELVSRLLHLHFKDDKTKVSGDALQLMVELLKVFVVEAAVRGVRQAQAEDALRVDVDQLEKVLPQLLLDF","sequence_length":81,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"526f7491b93203c11cd49c09d21d54d9e069f898a818a0ee39e93cceb5e399d6","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/A8MT69.json","taxon_id":"9606","uniprot_accession":"A8MT69","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/localization/go/fancm-mhf-complex-go0071821.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0071821","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/localization/go/fancm-mhf-complex-go0071821.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/cdd/histone-fold-domain-found-in-centromere-protein-x-cenp-x-and-similar-p-cd22921.yaml","qualification_status":"NOT_ASSESSED","record_id":"CDD:cd22921","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/cdd/histone-fold-domain-found-in-centromere-protein-x-cenp-x-and-similar-p-cd22921.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/cenp-x-pf09415.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF09415","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/cenp-x-pf09415.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:Q3E829","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF09415"],"protein_name":"Inner kinetochore subunit MHF2","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"6465215845867559275f8abde99585dd7990a3374be8d443649b98419c5fc317","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MLSKEALIKILSQNEGGNDMKIADEVVPMIQKYLDIFIDEAVLRSLQSHKDINGERGDKSPLELSHQDLERIVGLLLMDM","sequence_length":80,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"6465215845867559275f8abde99585dd7990a3374be8d443649b98419c5fc317","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q3E829.json","taxon_id":"559292","uniprot_accession":"Q3E829","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/localization/go/inner-kinetochore-go0000939.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0000939","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/localization/go/inner-kinetochore-go0000939.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/cdd/histone-fold-domain-found-in-centromere-protein-x-cenp-x-and-similar-p-cd22921.yaml","qualification_status":"NOT_ASSESSED","record_id":"CDD:cd22921","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/cdd/histone-fold-domain-found-in-centromere-protein-x-cenp-x-and-similar-p-cd22921.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/cenp-x-pf09415.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF09415","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/cenp-x-pf09415.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/1-20-5-4980-1-20-5-4980.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:1.20.5.4980","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/1-20-5-4980-1-20-5-4980.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/6-10-130-30-6-10-130-30.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:6.10.130.30","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/6-10-130-30-6-10-130-30.yaml"}],"pfam_ids":["PF09415"],"protein_name":"Centromere protein X","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MEGNSGFRKELVSRLLHLHFRDCKTKVSGDALQLMAEFLRIFVLEAAVRGVWQAQAEDLDVVEVDQLEKVLPQLLLDF","sequence_length":78,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"2bb568b76fd05012c84cb20d8bc93555f1a90221c3574331aabe5516187cd7c7","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q8C4X1.json","taxon_id":"10090","uniprot_accession":"Q8C4X1","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Arabidopsis thaliana","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/localization/go/fancm-mhf-complex-go0071821.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0071821","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/localization/go/fancm-mhf-complex-go0071821.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/cdd/histone-fold-domain-found-in-centromere-protein-x-cenp-x-and-similar-p-cd22921.yaml","qualification_status":"NOT_ASSESSED","record_id":"CDD:cd22921","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/cdd/histone-fold-domain-found-in-centromere-protein-x-cenp-x-and-similar-p-cd22921.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/6-10-130-30-6-10-130-30.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:6.10.130.30","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/6-10-130-30-6-10-130-30.yaml"}],"pfam_ids":["PF09415"],"protein_name":"Protein MHF2 homolog","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MDANNTFDSDLIHAIFKHIWARRFRERERSDAIDATEAEVALGTTKKNRLASANANALKLSCELLKSFVSEAVQRAAIIAEAEGMEKIEATHLERILPQLLLDF","sequence_length":104,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"b24fd379e7571f2c57485341552da453f7708776f0e241b7930a28f25077c590","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q8L7N3.json","taxon_id":"3702","uniprot_accession":"Q8L7N3","uniprot_release":"2026_03"}],"pfam_id":"PF09415","short_name":"CENP-X","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}