{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF09495","protein_label":"Leydig cell tumor 10 kDa protein","reviewed":true,"short_name":"DUF2462","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf2462-pf09495.yaml","source_record_id":"Pfam:PF09495","source_record_label":"Protein of unknown function (DUF2462)","source_section":"canonical_examples","taxon_id":"NCBITaxon:10116","taxon_label":"Rattus norvegicus","uniprot_accession":"Q05310","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF09495","protein_label":"Uncharacterized protein YLR363W-A","reviewed":true,"short_name":"DUF2462","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf2462-pf09495.yaml","source_record_id":"Pfam:PF09495","source_record_label":"Protein of unknown function (DUF2462)","source_section":"canonical_examples","taxon_id":"NCBITaxon:559292","taxon_label":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","uniprot_accession":"Q3E747","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF09495","protein_label":"Leydig cell tumor 10 kDa protein homolog","reviewed":true,"short_name":"DUF2462","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf2462-pf09495.yaml","source_record_id":"Pfam:PF09495","source_record_label":"Protein of unknown function (DUF2462)","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q9UNZ5","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF09495","protein_label":"","reviewed":null,"short_name":"DUF2462","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf2462-pf09495.yaml","source_record_id":"Pfam:PF09495","source_record_label":"Protein of unknown function (DUF2462)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":2360,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function","description_says_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":3,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":1},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This protein is highly conserved, but its function is unknown. It can be isolated from HeLa cell nucleoli and is found to be homologous with Leydig cell tumour protein whose function is unknown [1, supplementary Table I].","domain_architectures":42,"interpro_id":"IPR019034","known_evidence_count":null,"matches":2783,"name":"Protein of unknown function (DUF2462)","partial_evidence_count":null,"pfam_id":"PF09495","proteins":2773,"proteomes":2494,"short_name":"DUF2462","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09495","structures":7,"taxa":6695,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF09495.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":2360,"domain_architectures":42,"matches":2783,"proteins":2773,"proteomes":2494,"structures":7,"taxa":6695},"curation_status":"SEEDED","description":"This protein is highly conserved, but its function is unknown. It can be isolated from HeLa cell nucleoli and is found to be homologous with Leydig cell tumour protein whose function is unknown [1, supplementary Table I].","id":"Pfam:PF09495","interpro_id":"InterPro:IPR019034","name":"Protein of unknown function (DUF2462)","pfam_id":"PF09495","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF2462","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09495"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF09495.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"fc74c690d05fb88c834e8854c59a78cb7af45392df29c215b9db88f49a80998e"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Rattus norvegicus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf2462-pf09495.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF09495","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf2462-pf09495.yaml"}],"pfam_ids":["PF09495"],"protein_name":"Leydig cell tumor 10 kDa protein","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAQGQRKFQAQKPKSKAAAAERSRGPRKGGRVIGPKKARVVQQQKLKKSLEVGIRKKIEHDVVMKASSSLPKKLALLKGASKKTGATPGKTPS","sequence_length":93,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"16ffdf80b2c04ca2675a06d623fbc5f0105b314b8a5adcdc61f3be2f0ad62e1c","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q05310.json","taxon_id":"10116","uniprot_accession":"Q05310","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf2462-pf09495.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF09495","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf2462-pf09495.yaml"}],"pfam_ids":["PF09495"],"protein_name":"Uncharacterized protein YLR363W-A","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MPQKPLKVTKKAKDPRRVTKKQKNLRKAAPLQLKSKKKSLQHLKKLKKSSSLTETTERLVASKVGHLELLRGTRKELEKGKKNSK","sequence_length":85,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"51fa6488e5bc13746b66358e5d6dd19a7bff74c7bde4dd15be16c9e824017414","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q3E747.json","taxon_id":"559292","uniprot_accession":"Q3E747","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf2462-pf09495.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF09495","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf2462-pf09495.yaml"}],"pfam_ids":["PF09495"],"protein_name":"Leydig cell tumor 10 kDa protein homolog","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAQGQRKFQAHKPAKSKTAAAASEKNRGPRKGGRVIAPKKARVVQQQKLKKNLEVGIRKKIEHDVVMKASSSLPKKLALLKAPAKKKGAAAATSSKTPS","sequence_length":99,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"4cea777455c2705a17f63c308505c5a46b02ad8c31cb887b3764340c948a450f","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9UNZ5.json","taxon_id":"9606","uniprot_accession":"Q9UNZ5","uniprot_release":"2026_03"}],"pfam_id":"PF09495","short_name":"DUF2462","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}