{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF09741","protein_label":"Uncharacterized protein KIAA0930 homolog","reviewed":true,"short_name":"DUF2045","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf2045-pf09741.yaml","source_record_id":"Pfam:PF09741","source_record_label":"Uncharacterized conserved protein (DUF2045)","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"Q3UE31","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF09741","protein_label":"Uncharacterized protein KIAA0930 homolog","reviewed":true,"short_name":"DUF2045","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf2045-pf09741.yaml","source_record_id":"Pfam:PF09741","source_record_label":"Uncharacterized conserved protein (DUF2045)","source_section":"canonical_examples","taxon_id":"NCBITaxon:10116","taxon_label":"Rattus norvegicus","uniprot_accession":"Q4G008","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF09741","protein_label":"Uncharacterized protein KIAA0930","reviewed":true,"short_name":"DUF2045","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf2045-pf09741.yaml","source_record_id":"Pfam:PF09741","source_record_label":"Uncharacterized conserved protein (DUF2045)","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q6ICG6","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF09741","protein_label":"","reviewed":null,"short_name":"DUF2045","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf2045-pf09741.yaml","source_record_id":"Pfam:PF09741","source_record_label":"Uncharacterized conserved protein (DUF2045)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"KNOWN_HISTORICAL_DUF"}],"family":{"alphafold_models":2265,"candidate_reasons":["short_name_matches_duf"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":3,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":1},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This entry represents Uncharacterized protein KIAA0930 homolog found in animals. KIAA0930 is localised in the cytosol and not secreted from cells. Expression of KIAA0930 (C22orf9) is significantly higher in pancreatic, colorectal, gastric, and tongue cancer tissues than in normal tissues [[cite:PUB00163385]].","domain_architectures":52,"interpro_id":"","known_evidence_count":null,"matches":2841,"name":"Uncharacterized conserved protein (DUF2045)","partial_evidence_count":null,"pfam_id":"PF09741","proteins":2724,"proteomes":1472,"short_name":"DUF2045","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09741","structures":0,"taxa":4691,"unknown_status":"KNOWN_HISTORICAL_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF09741.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":2265,"domain_architectures":52,"matches":2841,"proteins":2724,"proteomes":1472,"structures":0,"taxa":4691},"curation_status":"SEEDED","description":"This entry represents Uncharacterized protein KIAA0930 homolog found in animals. KIAA0930 is localised in the cytosol and not secreted from cells. Expression of KIAA0930 (C22orf9) is significantly higher in pancreatic, colorectal, gastric, and tongue cancer tissues than in normal tissues [[cite:PUB00163385]].","id":"Pfam:PF09741","name":"Uncharacterized conserved protein (DUF2045)","pfam_id":"PF09741","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"KNOWN_HISTORICAL_DUF","short_name":"DUF2045","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09741"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF09741.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"e5feba8a4c5b4c8d6b43582825b337ffd6984cfe2e0691f9e1d7da12e33c0dc0"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf2045-pf09741.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF09741","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf2045-pf09741.yaml"}],"pfam_ids":["PF09741"],"protein_name":"Uncharacterized protein KIAA0930 homolog","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MLRAIAEERGRLSLRREVCGLGCFKDDRIVFWTWMFSTYFMEKLAPRQDDMLFYVRRKRAYPGNEGTIDGRKAEAEPEVEVEVYRRDSKKLPGLGDPDIDWEESVCLNLILQKLDYMVTCAVCTRADGGDIHIHRKKSQQVFASPSKHPMDSKGEESKMSYPNIFFMIDSFEEVFSDMTVGEGEMVCVELVASDKTNTFQGVIFQGSIRYEALKKVYDNRVSVAARMAQKMSFGFYKYNNMEFVRMKGPQGKGHAEMAVSRVSTGDTSPCGTEDSSPASPMHERVTSFSTPPTPERNNRPAFFSPSLKRKVPRNRIAEMKKSHSANDSEEFFREDDSGADLHNATNLRSRSLSGTGRSLVGSWLKLNRADGNFLLYAHLTYVTLPLHRILTDILEVRQKPILMT","sequence_length":404,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"9bec7006093b6c03cc770e69c96f695c8a586012c2e53a224a512d740b960ba3","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q3UE31.json","taxon_id":"10090","uniprot_accession":"Q3UE31","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Rattus norvegicus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf2045-pf09741.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF09741","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf2045-pf09741.yaml"}],"pfam_ids":["PF09741"],"protein_name":"Uncharacterized protein KIAA0930 homolog","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MLRAIAEERGRLSLRREVCGLGCFKDDRIVFWTWMFSTYFMEKLAPRQDDMLFYVRRKRAYTGSESTADGRKAEAEPEVEVEVYRRDSKKLPGLGDPDIDWEESVCLNLILQKLDYMVTCAVCTRADGGDIHIHRKKSQQVFASPSKHPMDSKGEESKMSYPNIFFMIDSFEEVFSDMTVGEGEMVCVELVASDKTNMFQGVIFQGSIRYEALKKVYDNRVSVAARMAQKMSFGFYKYNNMEFVRMKGPQGKGHAEMAVSRVSTGDTSPYGTEDSSPASPMHERVTSFSTPPTPERNNRPAFFSPSLKRKVPRNRIAEMKKSHSANDSEEFFREDDGGADLHNATNLRSRSLSGTGRSLVGSWLKLSRADGNFLLYAHLTYVTLPLHRILTDILEVRQKPILMT","sequence_length":404,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"80b82bf458b0763ed1754bab4c5127a1df39bd534aa182e7f72c52bded68baa2","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q4G008.json","taxon_id":"10116","uniprot_accession":"Q4G008","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf2045-pf09741.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF09741","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf2045-pf09741.yaml"}],"pfam_ids":["PF09741"],"protein_name":"Uncharacterized protein KIAA0930","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MLRAIAEERGRLSLRREVCGLGCFKDDRIVFWTWMFSTYFMEKWAPRQDDMLFYVRRKLAYSGSESGADGRKAAEPEVEVEVYRRDSKKLPGLGDPDIDWEESVCLNLILQKLDYMVTCAVCTRADGGDIHIHKKKSQQVFASPSKHPMDSKGEESKISYPNIFFMIDSFEEVFSDMTVGEGEMVCVELVASDKTNTFQGVIFQGSIRYEALKKVYDNRVSVAARMAQKMSFGFYKYSNMEFVRMKGPQGKGHAEMAVSRVSTGDTSPCGTEEDSSPASPMHERVTSFSTPPTPERNNRPAFFSPSLKRKVPRNRIAEMKKSHSANDSEEFFREDDGGADLHNATNLRSRSLSGTGRSLVGSWLKLNRADGNFLLYAHLTYVTLPLHRILTDILEVRQKPILMT","sequence_length":404,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"9f2694cae6f51d7d2f09f2fbfbea049c1b3d007f596232a497317b94ce642bba","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q6ICG6.json","taxon_id":"9606","uniprot_accession":"Q6ICG6","uniprot_release":"2026_03"}],"pfam_id":"PF09741","short_name":"DUF2045","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
