{"cross_mech":[],"family":{"alphafold_models":3230,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This domain is found at the N-terminal of Nuclear speckle splicing regulatory protein 1 (NRP1, also known as Nuclear speckle-related protein 70 and Coiled-coil domain-containing protein 55) and contains a coiled-coil domain that plays a critical role in NRP1 alternative splicing activity and self-oligomerization. NRP1 is a RNA-binding protein that mediates pre-mRNA alternative splicing regulation [[cite:PUB00093376],[cite:PUB00093375]].","domain_architectures":73,"interpro_id":"IPR018612","known_evidence_count":null,"matches":3787,"name":"Nuclear speckle splicing regulatory protein 1, N-terminal","partial_evidence_count":null,"pfam_id":"PF09745","proteins":3772,"proteomes":3150,"short_name":"NSRP1_N","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09745","structures":0,"taxa":8427,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF09745.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":3230,"domain_architectures":73,"matches":3787,"proteins":3772,"proteomes":3150,"structures":0,"taxa":8427},"curation_status":"SEEDED","description":"This domain is found at the N-terminal of Nuclear speckle splicing regulatory protein 1 (NRP1, also known as Nuclear speckle-related protein 70 and Coiled-coil domain-containing protein 55) and contains a coiled-coil domain that plays a critical role in NRP1 alternative splicing activity and self-oligomerization. NRP1 is a RNA-binding protein that mediates pre-mRNA alternative splicing regulation [[cite:PUB00093376],[cite:PUB00093375]].","id":"Pfam:PF09745","interpro_id":"InterPro:IPR018612","name":"Nuclear speckle splicing regulatory protein 1, N-terminal","pfam_id":"PF09745","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"NSRP1_N","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09745"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF09745.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"da633d8ec5d657424d734b2a7525237b1b6c1e604150bffe141293cf41efcdf0"}},"protein_examples":{"candidate_count":4,"discovery_scanned":true,"example_count":4,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Caenorhabditis elegans","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/nuclear-speckle-splicing-regulatory-protein-1-n-terminal-ipr018612.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR018612","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/nuclear-speckle-splicing-regulatory-protein-1-n-terminal-ipr018612.yaml"}],"pfam_ids":["PF09745"],"protein_name":"Nuclear speckle splicing regulatory protein 1 homolog","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MASKRHVGLNIRKKDEPKAAPIRVSSVFGDDDDDDNVPATATNMASASVIRVQKAAEREHQKAEAEDPTIFDYDGNYDEIQAIKNEKKEEARKADKNRESKYAENIIKAHARRQLEQFSREERQQLREREKEGDEFDDKEVFVTGAYRKQQEEVKKHREQEAEEAAFNDMTSVQKQKLWEIGMGRTLLNDLARDPTAIKQRKKEQKNVRKREDSDEEIDPKPEKSDKKPAEKLKKSIYSDDSDEEKAPKPPQKNFEGDLKPGLNTVSKKKATTHAERIRQRNYTPTPPSSDDEGARAPRARRRTSSPSPTSRKSIESRESGSRRSPEGKSEKSEKAPKISLKDKLKPKKIDKEARLDGLKEILKQRNTEEDIEAARQRYFERKEQGIVVPPL","sequence_length":392,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"d4c7a47c731eb4e439e50f512800a7005d93f5945c62953fbc2259f9c7316307","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q09252.json","taxon_id":"6239","uniprot_accession":"Q09252","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Rattus norvegicus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/nsrp1-n-pf09745.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF09745","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/nsrp1-n-pf09745.yaml"}],"pfam_ids":["PF09745","PF20427"],"protein_name":"Nuclear speckle splicing regulatory protein 1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAIPGRQYGLILPKKTQPLNRVLQKPSVFGNDSDDDEASVSESLQREAAKKQAMRQTKLEIQKALAEDSTVYEYDSIYDEMQKKKEENNPKLLMGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLEERAEEEEREKRAAALEARLDVTKQKDLSGFYRHLLNQAVGEEAVPKSSFREARTVIKEEKLRGYPDETNSENRPQQNCALQSGVEEAEENPDADSDSEESCDDGERGDHKVKSRGEEDTGASTKYLKHHKNHTHSRSSSEEGGLSTKYHSRSSQSRGHEHKGGQHQDRQSRDQESCHKDRSHREEKSSHRHREASHKDHHWKRHEHEDKPKGRGQGERQDREWKREKYSSREQEKDRQWNDHDRYSEKEKKGKEKEEHRKARRERCEDGAKYRERKKPEGSGQSSERHRDRRESSPRPRPEDDLLDQERSSKARNTEKDKGEQGKPPRSETSLATKHRLTEERPEKGSQPERPPEAVSKFAKRSNEETVMSARDRYLARQMARINAKTYIEKEDD","sequence_length":547,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"426ca0b52f45dba03b9751cd7fa0caac0efa40552b9c074dbcd62300308ddc7c","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q4FZU3.json","taxon_id":"10116","uniprot_accession":"Q4FZU3","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/nuclear-speckle-splicing-regulatory-protein-1-n-terminal-ipr018612.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR018612","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/nuclear-speckle-splicing-regulatory-protein-1-n-terminal-ipr018612.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/nuclear-speckle-splicing-regulatory-protein-1-rs-like-domain-ipr046850.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR046850","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/nuclear-speckle-splicing-regulatory-protein-1-rs-like-domain-ipr046850.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/nrp1-c-pf20427.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF20427","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/nrp1-c-pf20427.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/nsrp1-n-pf09745.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF09745","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/nsrp1-n-pf09745.yaml"}],"pfam_ids":["PF09745","PF20427"],"protein_name":"Nuclear speckle splicing regulatory protein 1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAIPGRQYGLILPKKTQPLHRVLQKPSVFGSDSDDDETSVSESLQREAAKKQAMKQTKLEIQKALAEDSTVYEYDSVYDEMQKKKEENNPKLLPGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMENGEFDDKEAFVTSAYKKKLEERAEEEEREKRAAALEAHLDVTKQKDLSGFYRHLLNQAVGEEAAPKSSFREARTVIKEEKLRGYPDETNSESRPPQQSCVLQRGAQEAEENPDADREFDDESSEDGEKRDHKVKSRGEDTGASMKHPKHHKNRAHSRSSSEERGLGTKHHSRGSQSRGHEHQDRQSRDQESCHKDRSHREEKSSHRHREASHKDHYWKKHEQEDKLKGREQEERQDREGKREKYSSREQERDRQRNDHDRYSEKEKKRKEKEEHTKARRERCEDSGKHREREKPEGHGQSSERHRDRRESSPRSRPKDDLDQERSSKARNTEKDKGEQGKPSHSETSLATKHRLAEERPEKGSEQERPPEAVSKFAKRSNEETVMSARDRYLARQMARINAKTYIEKEDD","sequence_length":542,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"3e7a49da5f0e05fb6dcf6bdd9896beba649adaf88a83c74d0116fbcbc60e6574","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q5NCR9.json","taxon_id":"10090","uniprot_accession":"Q5NCR9","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/nuclear-speckle-splicing-regulatory-protein-1-n-terminal-ipr018612.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR018612","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/nuclear-speckle-splicing-regulatory-protein-1-n-terminal-ipr018612.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/nuclear-speckle-splicing-regulatory-protein-1-rs-like-domain-ipr046850.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR046850","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/nuclear-speckle-splicing-regulatory-protein-1-rs-like-domain-ipr046850.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/nrp1-c-pf20427.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF20427","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/nrp1-c-pf20427.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/nsrp1-n-pf09745.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF09745","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/nsrp1-n-pf09745.yaml"}],"pfam_ids":["PF09745","PF20427"],"protein_name":"Nuclear speckle splicing regulatory protein 1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAIPGRQYGLILPKKTQQLHPVLQKPSVFGNDSDDDDETSVSESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQMARVNAKTYIEKEDD","sequence_length":558,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"7cd14aa4d9427b40f680099b211eac69f98bf2c7458d0197063928cecaa90fcd","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9H0G5.json","taxon_id":"9606","uniprot_accession":"Q9H0G5","uniprot_release":"2026_03"}],"pfam_id":"PF09745","short_name":"NSRP1_N","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
